Biochemical analysis of genetic recombination in eukaryotes.

Abstract:

:Recent studies concerning molecular mechanisms of genetic recombination in eukaryotes are reviewed. Since many of these studies have focused on the testable predictions arising from the hybrid DNA theory of genetic recombination, this theory is summarised. Experiments to determine the time of meiotic crossing-over and the structure of the synaptonemal complex which facilitates meiotic crossing-over are described. Investigations of DNA nicking and repair events implicated in recombination are discussed. Properties of proteins which may facilitate hybrid DNA formation, and biochemical evidence for hybrid DNA formation are presented. Finally, a nuclease which has been implicated in gene conversion is described.

journal_name

Heredity (Edinb)

journal_title

Heredity

authors

Pukkila PJ

doi

10.1038/hdy.1977.61

subject

Has Abstract

pub_date

1977-10-01 00:00:00

pages

193-217

issue

2

eissn

0018-067X

issn

1365-2540

journal_volume

39

pub_type

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