Hepatitis B virus DNA detected by PCR in sera and liver tissues of Chinese patients with chronic liver diseases.

Abstract:

:To investigate the HBV infection and its replication in Chinese patients with chronic liver disease, polymerase chain reaction (PCR) was employed to detect hepatitis B virus DNA in sera of 410 patients with chronic liver disease and liver samples from 188 patients. The HBV DNA detectability in all serum samples was 58%. Among them 100% HBeAg-positive and 58% anti-HBe cases were HBV DNA detectable respectively. However, HBV DNA was also found in 23% HBsAg-negative/anti-HBc positive chronic cases. Furthermore, 30% anti-HBs positive chronic cases who had neutralizing antibody against HBV infection, continued to contain HBV DNA. Our findings indicate that HBV infection and its replication are dominant cause of chronic liver disease and some HBV variants may escape from the protective antibody to induce chronic liver disease, even anti-HBs antibody circulated.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Zhang YY,Guo LS,Li L,Zhang YD,Hao LJ,Hansson BG,Nordenfelt E

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

7-12

issue

1

eissn

0366-6999

issn

2542-5641

journal_volume

106

pub_type

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