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Blood volume distribution in lung injury.

Abstract：

:Mild hydrochloric acid was used to induce injury in the caudal section of one lung in each of 10 dogs. 99mTc-red blood cells were injected intravenously. Blood samples were drawn prior to sacrifice. Lung and blood samples were weighed, assayed for radioactivity and dried to constant weight. Assuming a uniform hematocrit, and hence a constant density, we computed blood volumes in terms of mass. The control lung had 4.32 +/- 0.62 g of extravascular lung water (EVLW) per g of bloodless dried weight (BLDW). Injury in the other lung was characterized by an elevated average of 7.08 +/- 0.79 g of EVLW per g of BLDW. The control lung contained 2.49 +/- 0.43 g of blood per g of BLDW and the injured lung contained a reduced amount of 1.69 +/- 0.55 g of blood per g of BLDW. In 8 subjects, injured portions retained the least blood volume per g of BLDW (a limiting value of 1.43 +/- 0.47 g per g). These results support a thesis of a reduction of blood volume in an injured area.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Chu RY,Sidhu N,Carlile P Jr

doi

10.1016/0969-8051(93)90110-g

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

167-70

issue

2

eissn

0969-8051

issn

1872-9614

pii

0969-8051(93)90110-G

journal_volume

20

pub_type

杂志文章

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