当前位置： SCI文献检索 > JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY期刊下所有文献 > Toxic oxygen metabolites and ischemia-reperfusion increase histamine synthesis and release in the isolated rat heart.

Toxic oxygen metabolites and ischemia-reperfusion increase histamine synthesis and release in the isolated rat heart.

Abstract：

:Histamine is synthetized in the heart, and released by ischemia-reperfusion injury in several species. Histamine has arrhythmogenic, chronotropic, inotropic and vasoactive effects. Cardiac histamine release during ischemia-reperfusion may be mediated by toxic oxygen metabolites. We studied the effect of ischemia-reperfusion and toxic oxygen metabolites on release and synthesis of histamine in the isolated rat heart (Langendorff model). The following groups were included: I, (n = 10) control perfusion for 60 min; II, (n = 7) H2O2 (200 microM) was given for 10 min followed by 50 min recovery; III, (n = 7) thiourea (15 mM) was given in addition to H2O2; IV, (n = 7) thiourea given alone; V, (n = 7) catalase (150 U/ml) plus H2O2; VI, (n = 7) 20 min ischemia followed by 40 min reperfusion. The contents of histamine in the coronary effluent and in cardiac tissue were measured repeatedly (radioenzymatic method). Ischemia-reperfusion and toxic oxygen metabolites increased release of histamine in the coronary effluent. Concomitantly the histamine contents in cardiac tissue increased, indicating increased synthesis of histamine.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Valen G,Kaszaki J,Szabó I,Nagy S,Vaage J

doi

10.1006/jmcc.1993.1005

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

31-40

issue

1

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(83)71005-9

journal_volume

25

pub_type

杂志文章

相关文献

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY文献大全
  • Effect of isoproterenol on myocardial mechanical function and cyclic AMP content in the fetal rabbit.

    abstract：:The effect of isoproterenol on mechanical function was studied in the isolated arterially perfused heart of the fetal (21st and 28th day of gestation) and newborn rabbits. The inotropic effect of isoproterenol in the fetus was less than in the newborn. In contrast, myocardial cyclic AMP levels after isoproterenol infu...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(87)80557-6

    authors： Okuda H,Nakanishi T,Nakazawa M,Takao A

    更新日期：1987-02-01 00:00:00

  • The external work-pressure time integral relationships and the afterload dependence of Frank-Starling mechanism.

    abstract：:The mechanisms underlying the Frank-Starling Law of the heart are elusive and the prevalent notion suggests that it is afterload independent. However, isolated fiber studies reveal that the afterload determines cardiac function through cross-bridge dependent mechanisms. The study explores the roles of the afterload, i...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2009.05.007

    authors： Sela G,Landesberg A

    更新日期：2009-10-01 00:00:00

  • The effects of the NMR shift-reagents Dy(PPP)2, Dy(TTHA) and Tm(DOTP) on developed pressure in isolated perfused rat hearts. The role of shift-reagent calcium complexes.

    abstract：:The 23Na NMR shift-reagent complexes (Dy(PPP)2, Dy(TTHA), and Tm(DOTP)) bind stoichiometric amounts of Ca2+. Thus, in perfused rat heart systems, a supplementation of Ca2+ is required to maintain the requisite extracellular free calcium concentration ([Ca(o)]f) and to approximate a physiological level of contractile f...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2001.1459

    authors： Gaszner B,Simor T,Hild G,Elgavish GA

    更新日期：2001-11-01 00:00:00

  • Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress.

    abstract：:Screening for cell surface proteins up-regulated under stress conditions may lead to the identification of new therapeutic targets. To search for genes whose expression was enhanced by treatment with oligomycin, a mitochondrial-F(0)F(1) ATP synthase inhibitor, signal sequence trapping was performed in H9C2 rat cardiac...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2009.10.014

    authors： Nagao K,Ono K,Iwanaga Y,Tamaki Y,Kojima Y,Horie T,Nishi H,Kinoshita M,Kuwabara Y,Hasegawa K,Kita T,Kimura T

    更新日期：2010-06-01 00:00:00

  • Decrease with senescence in the norepinephrine-induced phosphorylation of myofilament proteins in isolated rat cardiac myocytes.

    abstract：:(1) The effects of norepinephrine on protein phosphorylation in isolated rat cardiac ventricular myocytes were determined by autoradiography on 32P-labelled proteins separated by electrophoresis; (2) In cells from young adult rats (6 months old) there was a marked increase due to norepinephrine (10(-8) to 10(-4) M) in...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(89)90678-0

    authors： Sakai M,Danziger RS,Staddon JM,Lakatta EG,Hansford RG

    更新日期：1989-12-01 00:00:00

  • Translational potential of thyroid hormone and its analogs.

    abstract：:Thyroid hormone has unique properties affecting the heart, and the vasculature and cholesterol metabolism. There is interest in using thyromimetic agents as possible treatment options for heart failure based on data demonstrating the ability of these agents to improve systolic and diastolic left ventricular function a...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2010.12.012

    authors： Arsanjani R,McCarren M,Bahl JJ,Goldman S

    更新日期：2011-10-01 00:00:00

  • Influence of isoproterenol on contractile protein function, excitation-contraction coupling, and energy turnover of isolated nonfailing human myocardium.

    abstract：:Previous animal experiments indicated that the effects of catecholamines on myocardial function and subcellular systems vary considerably depending on the species and type of myocardium investigated. In the present study, we used isometric force and heat measurements to investigate the influence of isoproterenol on en...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1994.1165

    authors： Hasenfuss G,Mulieri LA,Leavitt BJ,Alpert NR

    更新日期：1994-11-01 00:00:00

  • AGXT2: An unnegligible aminotransferase in cardiovascular and urinary systems.

    abstract：:Cardiovascular diseases (CVDs) and renal impairment interact in a complex and interdependent manner, which makes clarification of possible pathogenesis between CVDs and renal diseases very challenging and important. There is increasing evidence showing that both asymmetric dimethylarginine (ADMA) and symmetric dimethy...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2017.09.010

    authors： Hu XL,Li MP,Song PY,Tang J,Chen XP

    更新日期：2017-12-01 00:00:00

  • Dual effect of the heart-targeting cytokine cardiotrophin-1 on glucose transport in cardiomyocytes.

    abstract：:Cardiotrophin-1 (CT-1) is a heart-targeting cytokine that is increased in the metabolic syndrome due to overexpression in the adipocytes. The effects of CT-1 on cardiomyocyte substrate metabolism remain unknown. We therefore determined the effects of CT-1 on basal and stimulated glucose transport in cardiomyocytes exp...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2012.12.015

    authors： Asrih M,Gardier S,Papageorgiou I,Montessuit C

    更新日期：2013-03-01 00:00:00

  • A phenotypic screen to identify hypertrophy-modulating microRNAs in primary cardiomyocytes.

    abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that control expression of complementary target mRNAs. A growing number of miRNAs has been implicated in the pathogenesis of cardiac diseases, mostly based not on functional data, but on the observation that they are dysregulated in diseased myocardium. Consequently, our kn...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2011.07.010

    authors： Jentzsch C,Leierseder S,Loyer X,Flohrschütz I,Sassi Y,Hartmann D,Thum T,Laggerbauer B,Engelhardt S

    更新日期：2012-01-01 00:00:00

  • Dysfunction of cardiac ryanodine receptors in the metabolic syndrome.

    abstract：:This study examined the hypothesis that the prediabetic metabolic syndrome alters expression, phosphorylation state and binding affinity of cardiac RyR2. Real-time PCR and Western blot analysis were used to assess mRNA and protein expression in the left ventricle, right ventricle and right atrium from control (n=5) an...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2006.04.018

    authors： Dincer UD,Araiza A,Knudson JD,Shao CH,Bidasee KR,Tune JD

    更新日期：2006-07-01 00:00:00

  • Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system.

    abstract：:In the human heart connexin(Cx)40, Cx43 and Cx45-containing gap junctional channels electrically couple cardiomyocytes, forming a functional syncytium. In the mouse heart, additionally, Cx30.2-containing gap junctions have been detected in the atrioventricular node where they are implicated, together with Cx45, in imp...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2008.12.007

    authors： Kreuzberg MM,Liebermann M,Segschneider S,Dobrowolski R,Dobrzynski H,Kaba R,Rowlinson G,Dupont E,Severs NJ,Willecke K

    更新日期：2009-04-01 00:00:00

  • Characterization of [3H]U69593 binding sites in the rat heart by receptor binding assays.

    abstract：:The binding properties of [3H]U69593, a selective k-ligand, in rat heart homogenates were characterized by direct and displacement receptor binding assays. It was found that there are substantial specific [3H]U69593 binding sites in the rat heart. They were saturable, reversible and stereospecific. Both association an...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(91)90086-2

    authors： Tai KK,Jin WQ,Chan TK,Wong TM

    更新日期：1991-11-01 00:00:00

  • Ca(2+) influx through L-type Ca(2+) channels and transient receptor potential channels activates pathological hypertrophy signaling.

    abstract：:Common cardiovascular diseases such as hypertension and myocardial infarction require that myocytes develop greater than normal force to maintain cardiac pump function. This requires increases in [Ca(2+)]. These diseases induce cardiac hypertrophy and increases in [Ca(2+)] are known to be an essential proximal signal ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2012.08.005

    authors： Gao H,Wang F,Wang W,Makarewich CA,Zhang H,Kubo H,Berretta RM,Barr LA,Molkentin JD,Houser SR

    更新日期：2012-11-01 00:00:00

  • Identification of right heart-enriched genes in a murine model of chronic outflow tract obstruction.

    abstract：:The right ventricle (RV) differs in several aspects from the left ventricle (LV) including its embryonic origin, physiological role and anatomical design. In contrast to LV hypertrophy, little is known about the molecular circuits, which are activated upon RV hypertrophy (RVH). We established a highly reproducible mod...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2010.07.014

    authors： Kreymborg Kg,Uchida S,Gellert P,Schneider A,Boettger T,Voswinckel R,Wietelmann A,Szibor M,Weissmann N,Ghofrani AH,Schermuly R,Schranz D,Seeger W,Braun T

    更新日期：2010-10-01 00:00:00

  • I(f) blocking potency of ivabradine is preserved under elevated endotoxin levels in human atrial myocytes.

    abstract：:Lower heart rate is associated with better survival in patients with multiple organ dysfunction syndrome (MODS), a disease mostly caused by sepsis. The benefits of heart rate reduction by ivabradine during MODS are currently being investigated in the MODIfY clinical trial. Ivabradine is a selective inhibitor of the pa...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2014.02.010

    authors： Scheruebel S,Koyani CN,Hallström S,Lang P,Platzer D,Mächler H,Lohner K,Malle E,Zorn-Pauly K,Pelzmann B

    更新日期：2014-07-01 00:00:00

  • Inhibition of beta-adrenergic signaling by intracellular AMP is independent of cell-surface adenosine receptors in rat cardiac cells.

    abstract：:We report a novel action of intracellular adenosine monophosphate (AMP) to inhibit beta-adrenergic signaling in isolated rat ventricular myocytes. Extracellular application of adenosine or AMP suppressed isoproterenol (Iso)-induced prolongation of action potential duration (APD). This effect was completely abolished b...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2007.07.059

    authors： Ogura K,Miake J,Sasaki N,Iwai C,Bahrudin U,Li P,Kato M,Iitsuka K,Hirota Y,Koshida T,Yamamoto Y,Inoue Y,Yano A,Adachi M,Igawa O,Kurata Y,Morisaki T,Shiota G,Shirayoshi Y,Haruaki N,Hisatome I

    更新日期：2007-11-01 00:00:00

  • Development of the coronary arteries in a murine model of transposition of great arteries.

    abstract：:Transposition of great arteries in humans is associated with a wide spectrum of coronary artery patterns. However, no information is available about how this pattern diversity develops. We have studied the development of the coronary arteries in mouse embryos with a targeted mutation of perlecan, a mutation that leads...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(03)00134-2

    authors： González-Iriarte M,Carmona R,Pérez-Pomares JM,Macías D,Costell M,Muñoz-Chápuli R

    更新日期：2003-07-01 00:00:00

  • Extracellular matrix remodeling in atrial fibrosis: mechanisms and implications in atrial fibrillation.

    abstract：:Atrial fibrosis has been strongly associated with the presence of heart diseases/arrhythmias, including congestive heart failure (CHF) and atrial fibrillation (AF). Inducibility of AF as a result of atrial fibrosis has been the subject of intense recent investigation since it is the most commonly encountered arrhythmi...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2009.09.001

    authors： Pellman J,Lyon RC,Sheikh F

    更新日期：2010-03-01 00:00:00

  • Reduced expression of mitochondrial electron transport chain proteins from hibernating hearts relative to ischemic preconditioned hearts in the second window of protection.

    abstract：:Although protection against necrosis has been observed in both hibernating (HIB) and ischemic preconditioned hearts in the second window of protection (SWOP), a comparison of the mitochondrial proteome between the two entities has not been previously performed. Anesthetized swine underwent instrumentation with a fixed...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2013.03.018

    authors： Cabrera JA,Butterick TA,Long EK,Ziemba EA,Anderson LB,Duffy CM,Sluiter W,Duncker DJ,Zhang J,Chen Y,Ward HB,Kelly RF,McFalls EO

    更新日期：2013-07-01 00:00:00

  • Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca(2+)-transient.

    abstract：:Local signaling domains and numerous interacting molecular pathways and substrates contribute to the whole-cell response of myocytes during β-adrenergic stimulation (βARS). We aimed to elucidate the quantitative contribution of substrates and their local signaling environments during βARS to the canine epicardial vent...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2011.02.007

    authors： Heijman J,Volders PG,Westra RL,Rudy Y

    更新日期：2011-05-01 00:00:00

  • Chronic β-adrenergic stimulation reverses depressed Ca handling in mice overexpressing inhibitor-2 of protein phosphatase 1.

    abstract：RATIONALE:A higher expression/activity of type 1 serine/threonine protein phosphatase 1 (PP1) may contribute to dephosphorylation of cardiac regulatory proteins triggering the development of heart failure. OBJECTIVE:Here, we tested the putatively protective effects of PP1 inhibitor-2 (I2) overexpression using a heart ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2018.10.022

    authors： Kirchhefer U,Hammer E,Heinick A,Herpertz T,Isensee G,Müller FU,Neumann J,Schulte K,Seidl MD,Boknik P,Schulte JS

    更新日期：2018-12-01 00:00:00

  • Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2: additional amino acids generated by frameshift cause accelerated inactivation.

    abstract：OBJECTIVE:The function of the C-terminus region of the human ether-a-go-go related gene (HERG) has not been well characterized except for its involvement in trafficking. To understand further the role of C-terminus region, we performed a functional analysis of a novel frameshift mutation (1122fs/147) identified in a Ja...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2004.09.010

    authors： Sasano T,Ueda K,Orikabe M,Hirano Y,Kawano S,Yasunami M,Isobe M,Kimura A,Hiraoka M

    更新日期：2004-12-01 00:00:00

  • Functional characterization of the novel DES mutation p.L136P associated with dilated cardiomyopathy reveals a dominant filament assembly defect.

    abstract：BACKGROUND:Dilated cardiomyopathy (DCM) could be caused by mutations in more than 40 different genes. However, the pathogenic impact of specific mutations is in most cases unknown complicating the genetic counseling of affected families. Therefore, functional studies could contribute to distinguish pathogenic mutations...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2015.12.015

    authors： Brodehl A,Dieding M,Biere N,Unger A,Klauke B,Walhorn V,Gummert J,Schulz U,Linke WA,Gerull B,Vorgert M,Anselmetti D,Milting H

    更新日期：2016-02-01 00:00:00

  • Endogenous antioxidants in isolated hypertrophied cardiac myocytes and hypoxia-reoxygenation injury.

    abstract：:Effects of hypoxia-reoxygenation (H-R) on myocytes isolated from 10 week hypertrophied and sham control rat hearts were studied. Myocyte hypertrophy was indicated by an increase in cell size. Superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) enzyme activities were significantly higher and lipid peroxidatio...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(08)80025-9

    authors： Kirshenbaum LA,Hill M,Singal PK

    更新日期：1995-01-01 00:00:00

  • Aspirin and clopidogrel treatment impair nitric oxide biosynthesis by platelets.

    abstract：:Aspirin and clopidogrel are used therapeutically for their anti-platelet effects. We examined the effects of aspirin and clopidogrel on basal and beta-adrenoceptor (beta-AR)-mediated platelet nitric oxide (NO) synthesis in healthy subjects and patients with coronary heart disease (CHD). Healthy subjects (n=19) were ra...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.yjmcc.2008.05.015

    authors： O'Kane PD,Reebye V,Ji Y,Stratton P,Jackson G,Ferro A

    更新日期：2008-08-01 00:00:00

  • Development of novel method of non-viral efficient gene transfer into neonatal cardiac myocytes.

    abstract：:To establish new treatment for cardiovascular disease, the development of safe and highly efficient vectors is necessary. Especially, non-viral vectors are considered to be ideal for human gene therapy, since recent adverse events with retroviral or adenoviral vectors have highlighted the issue of safety. Although we ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2005.06.007

    authors： Tashiro H,Aoki M,Isobe M,Hashiya N,Makino H,Kaneda Y,Ogihara T,Morishita R

    更新日期：2005-09-01 00:00:00

  • Caspase activation and mitochondrial cytochrome C release during hypoxia-mediated apoptosis of adult ventricular myocytes.

    abstract：:Oxygen deprivation for prolonged periods leads to cardiac cell death and ventricular dysfunction. The ability to prevent myocardial cell death would be of significant therapeutic value in maintaining cardiac function after injury. While caspases have been suggested to play a critical role in apoptosis, their involveme...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1999.1057

    authors： de Moissac D,Gurevich RM,Zheng H,Singal PK,Kirshenbaum LA

    更新日期：2000-01-01 00:00:00

  • Influence of action potential duration and resting potential on effects of quinidine, lidocaine and ethmozin on Vmax in guinea-pig papillary muscles.

    abstract：:The effects of class I antiarrhythmic drugs (quinidine, lidocaine, ethmozin) on the maximum upstroke velocity (Vmax) of the action potential (AP) of guinea-pig papillary muscles were investigated in the presence and absence of nifedipine and a potassium-free solution. Nifedipine (10 microM) decreased AP duration from ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(91)90029-l

    authors： Jurevicius J,Muckus K,Macianskiene R,Chmel-Dunaj GN

    更新日期：1991-02-01 00:00:00

  • Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection.

    abstract：:The mitochondrial permeability transition, an established mechanism for heart diseases, is a long-standing mystery of mitochondrial biology and a prime drug target for cardioprotection. Several hypotheses about its molecular nature have been put forward over the years, and the prevailing view is that permeabilization ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2020.05.014

    authors： Carraro M,Carrer A,Urbani A,Bernardi P

    更新日期：2020-07-01 00:00:00