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Characterization of [3H]U69593 binding sites in the rat heart by receptor binding assays.

Abstract：

:The binding properties of [3H]U69593, a selective k-ligand, in rat heart homogenates were characterized by direct and displacement receptor binding assays. It was found that there are substantial specific [3H]U69593 binding sites in the rat heart. They were saturable, reversible and stereospecific. Both association and dissociation rates were monophasic and the Scatchard plot was linear, indicating a homogeneity of binding sites. The Hill coefficient was close to 1, indicating an absence of cooperativity. The Bmax and Kd were 7.91 fmol/mg and 2.92 nM, respectively. The binding sites were most abundant in the right atrium, followed by right ventricle, left ventricle and left atrium in descending order. The study provides information on the properties and distribution of k-binding sites in the rat heart.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Tai KK,Jin WQ,Chan TK,Wong TM

doi

10.1016/0022-2828(91)90086-2

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

1297-302

issue

11

eissn

0022-2828

issn

1095-8584

pii

0022-2828(91)90086-2

journal_volume

23

pub_type

杂志文章

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