当前位置： SCI文献检索 > JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY期刊下所有文献 > Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress.

Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress.

Abstract：

:Screening for cell surface proteins up-regulated under stress conditions may lead to the identification of new therapeutic targets. To search for genes whose expression was enhanced by treatment with oligomycin, a mitochondrial-F(0)F(1) ATP synthase inhibitor, signal sequence trapping was performed in H9C2 rat cardiac myoblasts. One of the genes identified was that for neural cell adhesion molecule (NCAM, CD56), a major regulator of development, cell survival, migration, and neurite outgrowth in the nervous system. Immunohistochemical analyses in a mouse myocardial infarction model revealed that NCAM was strongly expressed in residual cardiac myocytes in the infarcted region. Increased expression of NCAM was also found during the remodeling period in a rat model of hypertension-induced heart failure. Lentivirus-mediated knockdown of NCAM decreased the cell growth and survival following oligomycin treatment in H9C2 cells. In primary rat neonatal cardiac myocytes, NCAM was also found to be up-regulated and played a protective role following oligomycin treatment. Analyses of downstream signaling revealed that knockdown of NCAM significantly decreased the basal AKT phosphorylation level. In contrast, NCAM mimetic peptide P2d activated AKT and significantly reduced oligomycin-induced cardiomyocyte death, which was abolished by treatment with the PI3K inhibitor LY-294002 as well as overexpression of the dominant-negative AKT mutant. These findings demonstrate that NCAM is a cardioprotective factor up-regulated under metabolic stress in cardiomyocytes and augmentation of this signal improved survival.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Nagao K,Ono K,Iwanaga Y,Tamaki Y,Kojima Y,Horie T,Nishi H,Kinoshita M,Kuwabara Y,Hasegawa K,Kita T,Kimura T

doi

10.1016/j.yjmcc.2009.10.014

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

1157-68

issue

6

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(09)00440-4

journal_volume

48

pub_type

杂志文章

相关文献

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY文献大全
  • 2-Tetradecylglycidic acid, an inhibitor of carnitine palmitoyltransferase-1, induces myocardial hypertrophy via the AT1 receptor.

    abstract：:Activation of the antiogensin II, type 1 (AT1) receptor mediates the myocardial response to numerous hypertrophic stimuli. This study tested the hypothesis that 2-tetradecylglycidic acid (TDGA), an oxirane carboxylate inhibitor of mitochondrial carnitine plamitoyltransferase-1, induces myocardial hypertrophy via the A...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1999.0977

    authors： Wolkowicz PE,Urthaler F,Forrest C,Shen H,Durand J,Wei CC,Oparil S,Dell'Italia LJ

    更新日期：1999-08-01 00:00:00

  • Metabolism, hypoxia and the diabetic heart.

    abstract：:The diabetic heart becomes metabolically remodelled as a consequence of exposure to abnormal circulating substrates and hormones. Fatty acid uptake and metabolism are increased in the type 2 diabetic heart, resulting in accumulation of intracellular lipid intermediates and an increased contribution of fatty acids towa...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2011.01.007

    authors： Heather LC,Clarke K

    更新日期：2011-04-01 00:00:00

  • Mitochondrial reactive oxygen species production and elimination.

    abstract：:Reactive oxygen species (ROS) play an important role in cardiovascular diseases, and one important source for ROS are mitochondria. Emission of ROS from mitochondria is the net result of ROS production at the electron transport chain (ETC) and their elimination by antioxidative enzymes. Both of these processes are hig...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2014.03.011

    authors： Nickel A,Kohlhaas M,Maack C

    更新日期：2014-08-01 00:00:00

  • Microtubules mobility affects the modulation of L-type I(Ca) by muscarinic and beta-adrenergic agonists in guinea-pig cardiac myocytes.

    abstract：:To investigate the interaction of cytoskeleton with the receptor modulation of ionic currents, we studied the effect of muscarinic and beta-adrenergic stimulation in adult guinea-pig ventricular cardiac myocytes treated with paclitaxel and colchicine, two drugs that respectively stabilize or destabilize microtubules. ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(02)00312-7

    authors： Malan D,Gallo MP,Bedendi I,Biasin C,Levi RC,Alloatti G

    更新日期：2003-02-01 00:00:00

  • Muscarinic stimulation and pinacidil produce similar facilitation of tachyarrhythmia induction in rat isolated atria.

    abstract：:Atrial tachyarrhythmias, the most common type of cardiac arrhythmias, are associated with greater stroke risk. Muscarinic cholinergic agonists have been shown to facilitate atrial tachyarrhythmia maintenance in the absence of cardiac disease. This has been attributed to action potential shortening, which enhances myoc...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2013.10.004

    authors： Zafalon N Jr,Oshiyama NF,Bassani JW,Bassani RA

    更新日期：2013-12-01 00:00:00

  • Regional biochemical remodeling in non-infarcted tissue of rat heart post-myocardial infarction.

    abstract：:Changes in the capacities of ATP-synthesizing reactions were analysed in residual non-infarcted myocardium following myocardial infarction. Rats were subjected to left coronary artery ligation (MI; n = 11) or to sham operation (sham; n = 18). Two months later, hearts were excised, rinsed and buffer-perfused isovolumic...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0143

    authors： Laser A,Ingwall JS,Tian R,Reis I,Hu K,Gaudron P,Ertl G,Neubauer S

    更新日期：1996-07-01 00:00:00

  • Autoantibodies from mothers of children with congenital heart block downregulate cardiac L-type Ca channels.

    abstract：:Congenital heart block (CHB) affects offspring of mothers with autoantibodies (positive IgG) to intracellular SSA/Ro and SSB/La ribonucleoproteins and is associated with high morbidity and mortality. Here, we show that maternal anti-Ro/La antibodies immunoreact with human fetal cardiomyocyte sarcolemma, recognize huma...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2001.1379

    authors： Qu Y,Xiao GQ,Chen L,Boutjdir M

    更新日期：2001-06-01 00:00:00

  • I(f) blocking potency of ivabradine is preserved under elevated endotoxin levels in human atrial myocytes.

    abstract：:Lower heart rate is associated with better survival in patients with multiple organ dysfunction syndrome (MODS), a disease mostly caused by sepsis. The benefits of heart rate reduction by ivabradine during MODS are currently being investigated in the MODIfY clinical trial. Ivabradine is a selective inhibitor of the pa...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2014.02.010

    authors： Scheruebel S,Koyani CN,Hallström S,Lang P,Platzer D,Mächler H,Lohner K,Malle E,Zorn-Pauly K,Pelzmann B

    更新日期：2014-07-01 00:00:00

  • SUR, ABC proteins targeted by KATP channel openers.

    abstract：:The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP family. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2004.11.030

    authors： Moreau C,Prost AL,Dérand R,Vivaudou M

    更新日期：2005-06-01 00:00:00

  • Beta-myosin heavy chain gene mutations and hypertrophic cardiomyopathy in Austrian children.

    abstract：:Hypertrophic cardiomyopathy occurs in two variants, either as an autosomal dominant familial disorder or as a sporadic disease without familial involvement. Different genes coding sarcomeric proteins of the heart have been identified as causing hypertrophic cardiomyopathy. Missense mutations in the cardiac beta-myosin...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2000.1287

    authors： Greber-Platzer S,Marx M,Fleischmann C,Suppan C,Dobner M,Wimmer M

    更新日期：2001-01-01 00:00:00

  • Role of myocardial redox and energy states in ischemia-stimulated release of atrial natriuretic peptide.

    abstract：:The correlations between myocardial redox and energy states and atrial natriuretic peptide (ANP) secretion were studied in the perfused rat heart by exposing the hearts to global and low-flow ischemia for varying periods. Atrial and ventricular energy states and immunoreactive ANP in the effluent perfusate were measur...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(92)93155-d

    authors： Uusimaa PA,Peuhkurinen KJ,Vuolteenaho O,Ruskoaho H,Hassinen IE

    更新日期：1992-02-01 00:00:00

  • Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes.

    abstract：:During lipid oversupply, the heart becomes insulin resistant, as exemplified by defective insulin-stimulated glucose uptake, and will develop diastolic dysfunction. In the healthy heart, not only insulin, but also increased contractile activity stimulates glucose uptake. Upon increased contraction both AMP-activated p...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2012.11.005

    authors： Steinbusch LK,Dirkx E,Hoebers NT,Roelants V,Foretz M,Viollet B,Diamant M,van Eys G,Ouwens DM,Bertrand L,Glatz JF,Luiken JJ

    更新日期：2013-02-01 00:00:00

  • Isolation of rat cardiac sarcoplasmic reticulum with improved Ca2+ uptake and ryanodine binding.

    abstract：:The instability of the oxalate-supported Ca2+ uptake activity of rat cardiac sarcoplasmic reticulum (CSR) in ventricular homogenates most likely accounts for the low specific activity of the rate of oxalate-supported Ca2+ uptake in previously reported fractions of isolated rat CSR. We have found that CSR vesicles with...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(91)90061-p

    authors： Feher JJ,Davis MD

    更新日期：1991-03-01 00:00:00

  • Identification and characterization of proteins in sarcoplasmic reticulum from normal and failing human left ventricles.

    abstract：:Monoclonal and polyclonal antibodies to the major sarcoplasmic reticulum proteins of rabbit skeletal and canine cardiac muscle have been used to identify and characterize the corresponding components of human cardiac sarcoplasmic reticulum. The Ca2(+)-transporting ATPase of human cardiac sarcoplasmic reticulum was ide...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(90)90990-j

    authors： Movsesian MA,Leveille C,Krall J,Colyer J,Wang JH,Campbell KP

    更新日期：1990-12-01 00:00:00

  • Inhibitory activity of antibodies against the human atrial 5-HT(4)receptor.

    abstract：:Antibodies directed against the second extracellular loop of G protein-coupled receptors have been shown to exert "agonist-like" activities. In order to test the hypothesis that this is a general phenomenon, antibodies were raised in rabbits against a synthetic peptide corresponding to the second extracellular loop of...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2000.1312

    authors： Sallé L,Eftekhari P,Aupart M,Cosnay P,Hoebeke J,Argibay JA

    更新日期：2001-03-01 00:00:00

  • Ischemic but not reperfusion arrhythmias depend upon serum potassium concentration.

    abstract：:The effects of variations in serum concentrations of potassium on the occurrence and severity of ischemia- and reperfusion-induced arrhythmias have been studied in conscious rats. Serum potassium concentrations were modified by maintaining rats on diets which varied in potassium concentration, by treatment with hydroc...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(92)93384-v

    authors： Saint KM,Abraham S,MacLeod BA,McGough J,Yoshida N,Walker MJ

    更新日期：1992-07-01 00:00:00

  • Cardiomyocyte specific overexpression of a 37 amino acid domain of regulator of G protein signalling 2 inhibits cardiac hypertrophy and improves function in response to pressure overload in mice.

    abstract：:Regulator of G protein signalling 2 (RGS2) is known to play a protective role in maladaptive cardiac hypertrophy and heart failure via its ability to inhibit Gq- and Gs- mediated GPCR signalling. We previously demonstrated that RGS2 can also inhibit protein translation and can thereby attenuate cell growth. This G pro...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2017.06.007

    authors： Lee KN,Lu X,Nguyen C,Feng Q,Chidiac P

    更新日期：2017-07-01 00:00:00

  • Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged hearts.

    abstract：:Ischemic tolerance decreases with aging and the cardioprotective effect of ischemic preconditioning (IPC) is impaired in aged animals. Although lifelong caloric restriction (CR) profoundly affects the physiological and pathophysiological modifications induced by aging and markedly increases life span in several specie...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2005.03.010

    authors： Shinmura K,Tamaki K,Bolli R

    更新日期：2005-08-01 00:00:00

  • Increased amounts of collagenase and gelatinase in porcine myocardium following ischemia and reperfusion.

    abstract：:We studied the presence of collagen degrading enzymes (matrix metalloproteinases, MMPs) in porcine myocardium following ischemia and late reperfusion. In nine pigs, left anterior descending coronary artery was occluded for 6 h followed by reperfusion for 3 h. Six pigs without coronary occlusion served as controls. Aft...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1998.0711

    authors： Danielsen CC,Wiggers H,Andersen HR

    更新日期：1998-07-01 00:00:00

  • Dose/response curves of lipoic acid R-and S-forms in the working rat heart during reoxygenation: superiority of the R-enantiomer in enhancement of aortic flow.

    abstract：:Micromolar concentrations of lipoic acid racemate added to a working rat heart during hypoxia have been previously found to improve aortic flow during subsequent reoxygenation. Since the R-form represents the naturally occurring form of lipoic acid, and the S-form does not reveal a positive influence on ATP synthesis ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(95)90012-8

    authors： Zimmer G,Beikler TK,Schneider M,Ibel J,Tritschler H,Ulrich H

    更新日期：1995-09-01 00:00:00

  • Measurement of electrically-induced Ca2+ transients in Quin2-loaded cardiac myocytes.

    abstract：:Quin2 is a fluorescent Ca2+-sensitive indicator which in its acetoxymethyl ester form can be loaded into the cytosolic compartment of cells without any disruption of the plasma membrane. Quin2 has been used with many cell types to measure changes of [Ca2+]i in response to hormones and other stimuli. In this report we ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(86)80919-1

    authors： Thomas AP,Selak M,Williamson JR

    更新日期：1986-05-01 00:00:00

  • Influence of action potential duration and resting potential on effects of quinidine, lidocaine and ethmozin on Vmax in guinea-pig papillary muscles.

    abstract：:The effects of class I antiarrhythmic drugs (quinidine, lidocaine, ethmozin) on the maximum upstroke velocity (Vmax) of the action potential (AP) of guinea-pig papillary muscles were investigated in the presence and absence of nifedipine and a potassium-free solution. Nifedipine (10 microM) decreased AP duration from ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(91)90029-l

    authors： Jurevicius J,Muckus K,Macianskiene R,Chmel-Dunaj GN

    更新日期：1991-02-01 00:00:00

  • Changes in mitochondrial matrix free calcium in perfused rat hearts subjected to hypoxia-reoxygenation.

    abstract：:Reperfusion or reoxygenation of ischaemic or hypoxic cardiac tissue results in increases in total cell calcium and cell lysis both of which are dependent on mitochondrial function. Although changes which occur during this period of exposure of the tissue to hypoxia predispose the heart to take up calcium on reoxygenat...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1993.1107

    authors： Allen SP,Darley-Usmar VM,McCormack JG,Stone D

    更新日期：1993-08-01 00:00:00

  • Serum from patients with chronic renal insufficiency alters growth characteristics and ANP mRNA expression of adult rat cardiac myocytes.

    abstract：:Left ventricular hypertrophy is very prevalent among patients with renal insufficiency. Known hypertrophic factors, such as systemic hypertension, do not adequately account for the prevalence of left ventricular hypertrophy in these patients. Circulating growth factors may stimulate cardiomyocyte growth and contribute...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0236

    authors： Yu JZ,Bondy GP,Allard MF,Thompson CR,Levin A,McManus BM

    更新日期：1996-12-01 00:00:00

  • Structure, regulation and function of avian glypican.

    abstract：:Glypicans are a group of membrane-bound heparan sulfate proteoglycans (HSPG) that are tissue specific and developmentally regulated. Transcripts for avian glypican are found in endocardial cushions, limb buds, somites and forebrain of early chick embryos. Since avian glypican is not well characterized, the cellular lo...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1997.0618

    authors： Niu S,Bahl JJ,Adamson C,Morkin E

    更新日期：1998-03-01 00:00:00

  • Molecular mechanisms in H2O2-induced increase in AT1 receptor gene expression in cardiac fibroblasts: A role for endogenously generated Angiotensin II.

    abstract：:The AT1 receptor (AT1R) mediates the manifold actions of angiotensin II in the cardiovascular system. This study probed the molecular mechanisms that link altered redox status to AT1R expression in cardiac fibroblasts. Real-time PCR and western blot analysis showed that H2O2 enhances AT1R mRNA and protein expression v...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2016.05.010

    authors： Anupama V,George M,Dhanesh SB,Chandran A,James J,Shivakumar K

    更新日期：2016-08-01 00:00:00

  • Differential expression of heat shock proteins in normal and failing human hearts.

    abstract：BACKGROUND:Heat shock proteins (hsp) constitute an endogenous stress response that protects cells from injury. Most work on these important proteins has focused on the immediate response to acute stress in cell culture systems and mammalian models of heart disease. Little is known about the expression of the hsps in hu...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1998.0646

    authors： Knowlton AA,Kapadia S,Torre-Amione G,Durand JB,Bies R,Young J,Mann DL

    更新日期：1998-04-01 00:00:00

  • The influence of lanthanum on the subcellular distribution of calcium in the perfused dog heart.

    abstract：:A newly developed method was used to make a direct study of the influence of lanthanum on the subcellular distribution of isotopic and elemental calcium in the isolated perfused dog heart. The trivalent cation was introduced into the heart for the last 5 min of a 60 min perfusion period. Developed pressure and dP/dt w...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(86)80944-0

    authors： Kolbeck RC,Speir WA Jr

    更新日期：1986-07-01 00:00:00

  • Globular adiponectin but not full-length adiponectin induces increased procoagulability in human endothelial cells.

    abstract：:Adiponectin (APN), a recently discovered adipocytokine, is present in human serum in a full length (fAPN) and a globular form (gAPN). gAPN is a proteolytic cleavage product of fAPN and seems to show independent biological activities compared to the properties of fAPN. The influence of gAPN and fAPN on procoagulability...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2007.10.018

    authors： Bobbert P,Antoniak S,Schultheiss HP,Rauch U

    更新日期：2008-02-01 00:00:00

  • Cardiomegaly due to myocyte hyperplasia in perinatal rats exposed to 200 ppm carbon monoxide.

    abstract：:Exposure to carbon monoxide (CO) during the fetal and neonatal period was used to evaluate cardiac ventricular regional weight and myocyte growth response to an increased hemodynamic load. Date-mated Sprague-Dawley rats inhaled 200 ppm CO from day 7 of pregnancy until parturition; another group of pregnant rats inhale...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(86)80913-0

    authors： Clubb FJ Jr,Penney DG,Baylerian MS,Bishop SP

    更新日期：1986-05-01 00:00:00