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Inhibition of beta-adrenergic signaling by intracellular AMP is independent of cell-surface adenosine receptors in rat cardiac cells.

Abstract：

:We report a novel action of intracellular adenosine monophosphate (AMP) to inhibit beta-adrenergic signaling in isolated rat ventricular myocytes. Extracellular application of adenosine or AMP suppressed isoproterenol (Iso)-induced prolongation of action potential duration (APD). This effect was completely abolished by an A(1)-receptor antagonist, DPCPX. Intracellular application of AMP, but not adenosine, attenuated Iso-induced APD prolongation. Iso-induced increases in the L-type Ca(2+) current (I(Ca,L)) were also inhibited by intracellular AMP. These inhibitory effects were not affected by either DPCPX or glibenclamide. In vitro, AMP directly inhibited PKA activity via binding to its regulatory subunit. These results suggest that intracellular AMP attenuates beta-adrenergic signaling by directly inhibiting PKA activity, independently of A(1)-purinergic receptor.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Ogura K,Miake J,Sasaki N,Iwai C,Bahrudin U,Li P,Kato M,Iitsuka K,Hirota Y,Koshida T,Yamamoto Y,Inoue Y,Yano A,Adachi M,Igawa O,Kurata Y,Morisaki T,Shiota G,Shirayoshi Y,Haruaki N,Hisatome I

doi

10.1016/j.yjmcc.2007.07.059

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

648-52

issue

5

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(07)01168-6

journal_volume

43

pub_type

杂志文章

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