Decrease with senescence in the norepinephrine-induced phosphorylation of myofilament proteins in isolated rat cardiac myocytes.

abstract：:Our laboratory has previously shown that adenoviral-mediated overexpression of Galphaq in neonatal rat ventricular cardiomyocytes increases the phosphorylation of Akt, a well-established anti-apoptotic effector. As demonstrated here, Galphaq expression protects cardiomyocytes against apoptosis induced by treatment wit...

journal_title：Journal of molecular and cellular cardiology

authors： Howes AL,Miyamoto S,Adams JW,Woodcock EA,Brown JH

更新日期：2006-05-01 00:00:00

abstract：:Left ventricular hypertrophy may lead to heart failure. The transition between hypertrophy and heart failure is, however, incompletely understood. On the cellular level, human heart failure is characterized by alterations in Ca(2+)-cycling proteins and beta-adrenergic receptor density, but the hypertrophied human hear...

journal_title：Journal of molecular and cellular cardiology

authors： DiPaola NR,Sweet WE,Stull LB,Francis GS,Schomisch Moravec C

更新日期：2001-06-01 00:00:00

abstract：:We previously established a new measuring method of the myocardial O2 consumption of mechanically unloaded rat left-ventricular slices. O 2 consumption of unstimulated myocardium corresponds to basal metabolism. We have found O2 consumption of stimulated myocardium to include basal metabolism and O 2 consumption for C...

journal_title：Journal of molecular and cellular cardiology

authors： Takaki M,Kohzuki H,Kawatani Y,Yoshida A,Ishidate H,Suga H

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Duchenne muscular dystrophy (DMD) is an X-linked disease characterized by skeletal muscle degeneration and a significant cardiomyopathy secondary to cardiomyocyte damage and myocardial loss. The molecular basis of DMD lies in the absence of the protein dystrophin, which plays critical roles in mechanical mem...

journal_title：Journal of molecular and cellular cardiology

authors： Meyers TA,Heitzman JA,Krebsbach AM,Aufdembrink LM,Hughes R,Bartolomucci A,Townsend D

更新日期：2019-03-01 00:00:00

abstract：:The contribution of endogenous NO to ischemia-reperfusion injury was studied in isolated perfused hearts of wild-type (WT) and endothelial NO synthase knockout (eNOS-) mice. The hearts were subjected to a 16-min period of global no-flow ischemia and were subsequently reperfused for 1 h. Cardiac contractile function wa...

journal_title：Journal of molecular and cellular cardiology

authors： Flögel U,Decking UK,Gödecke A,Schrader J

更新日期：1999-04-01 00:00:00

abstract：:We report a novel action of intracellular adenosine monophosphate (AMP) to inhibit beta-adrenergic signaling in isolated rat ventricular myocytes. Extracellular application of adenosine or AMP suppressed isoproterenol (Iso)-induced prolongation of action potential duration (APD). This effect was completely abolished b...

journal_title：Journal of molecular and cellular cardiology

authors： Ogura K,Miake J,Sasaki N,Iwai C,Bahrudin U,Li P,Kato M,Iitsuka K,Hirota Y,Koshida T,Yamamoto Y,Inoue Y,Yano A,Adachi M,Igawa O,Kurata Y,Morisaki T,Shiota G,Shirayoshi Y,Haruaki N,Hisatome I

更新日期：2007-11-01 00:00:00

abstract：:Microtubules have been implicated in a number of muscle-specific functions, including sarcomerogenesis and the regulation of heart cell beating rate. Post-translationally modified microtubules (MTs) have been correlated, in other cell types, with MTs of increased stability and possibly distinct functions. This study w...

journal_title：Journal of molecular and cellular cardiology

authors： Webster DR

更新日期：1997-06-01 00:00:00

abstract：:The importance of the Na+/K+/Cl- co-transport system of the rat myocardial sarcolemma was studied under hypothermic ischemia by investigating the effect of the co-transport blockers furosemide and bumetanide on the sodium influx into the myocardium. The intracellular Na+ accumulation during hypothermic ischemia was fo...

journal_title：Journal of molecular and cellular cardiology

authors： Rubin Y,Navon G

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Fabry disease is an X-linked disease caused by mutations in α-galactosidase A (GLA); these mutations result in the accumulation of its substrates, mainly globotriaosylceramide (Gb3). The accumulation of glycosphingolipids induces pathogenic changes in various organs, including the heart, and Fabry cardiomyop...

journal_title：Journal of molecular and cellular cardiology

authors： Kuramoto Y,Naito AT,Tojo H,Sakai T,Ito M,Shibamoto M,Nakagawa A,Higo T,Okada K,Yamaguchi T,Lee JK,Miyagawa S,Sawa Y,Sakata Y,Komuro I

更新日期：2018-08-01 00:00:00

abstract：:We have compared and contrasted the actions of (-)isoproterenol and (+/-) trimetoquinol on rabbit heart preparations. In the presence of either GTP or Gpp[NH]p (guanosine-5'-(beta, gamma imino) triphosphate), trimetoquinol displayed partial agonist activity in stimulating adenylate cyclase activity in a particulate ra...

journal_title：Journal of molecular and cellular cardiology

authors： Babich M,Atkinson J,Piascik MT

更新日期：1985-06-01 00:00:00

abstract：:Several investigators have demonstrated that the opioid pathway is involved in tissue preservation during hypoxia or ischemia and that this protection is mediated via the delta (delta)-opioid receptor. Subsequently, we have shown that opioid receptors are involved in ischemic preconditioning (PC) in the rat heart and ...

journal_title：Journal of molecular and cellular cardiology

authors： Schultz JJ,Hsu AK,Gross GJ

更新日期：1997-08-01 00:00:00

abstract：:Brain renin-angiotensin system (RAS) hyperactivity has been implicated in sympathetic hyperactivity and progressive left ventricular (LV) dysfunction after myocardial infarction (MI). Angiotensin III, generated by aminopeptidase A (APA), is one of the main effector peptides of the brain RAS in the control of cardiac f...

journal_title：Journal of molecular and cellular cardiology

authors： Boitard SE,Marc Y,Keck M,Mougenot N,Agbulut O,Balavoine F,Llorens-Cortes C

更新日期：2019-02-01 00:00:00

abstract：:Quin2 is a fluorescent Ca2+-sensitive indicator which in its acetoxymethyl ester form can be loaded into the cytosolic compartment of cells without any disruption of the plasma membrane. Quin2 has been used with many cell types to measure changes of [Ca2+]i in response to hormones and other stimuli. In this report we ...

journal_title：Journal of molecular and cellular cardiology

authors： Thomas AP,Selak M,Williamson JR

更新日期：1986-05-01 00:00:00

abstract：:Activation of both mTOR and its downstream target, S6K1 (p70 S6 kinase) have been implicated to affect cardiac hypertrophy. Our earlier work, in a feline model of 1-48 h pressure overload, demonstrated that mTOR/S6K1 activation occurred primarily through a PKC/c-Raf pathway. To further delineate the role of specific P...

journal_title：Journal of molecular and cellular cardiology

authors： Moschella PC,Rao VU,McDermott PJ,Kuppuswamy D

更新日期：2007-12-01 00:00:00

abstract：:Glutamic dehydrogenase purified from rat heart mitochondria has been characterized with regard to its substrate kinetics and the influence of nucleotides and potassium phosphate on its kinetic properties. The enzyme had characteristics similar to liver mitochondrial glutamic dehydrogenase. These included several doubl...

journal_title：Journal of molecular and cellular cardiology

authors： McDaniel HG,Jenkins R,Yeh M,Razzaque A

更新日期：1984-04-01 00:00:00

abstract：:Iron overload is associated with long-term cardiac iron accumulation and tissue changes such as fibrosis. To determine short-term iron-dependent changes in expression of genes associated with iron homeostasis and fibrosis we measured mRNA on Northern blots prepared from cultured rat neonatal cardiomyocytes and non-myo...

journal_title：Journal of molecular and cellular cardiology

authors： Parkes JG,Liu Y,Sirna JB,Templeton DM

更新日期：2000-02-01 00:00:00

abstract：:Peroxynitrite and hydroxyl radical are reactive oxidants produced during myocardial reperfusion injury. In various cell types, including macrophages and smooth muscle cells, peroxynitrite and hydrogen peroxide cause DNA single strand breakage, which triggers the activation of the nuclear enzyme poly (ADP-ribose) synth...

journal_title：Journal of molecular and cellular cardiology

authors： Gilad E,Zingarelli B,Salzman AL,Szabó C

更新日期：1997-09-01 00:00:00

abstract：:Function and various parameters of myocardial substrate and energy metabolism were measured in preload-controlled isolated working guinea-pig hearts perfused with normoxic (95% O2) and hypoxic (30 to 45% O2) Krebs-Henseleit buffers ([Ca2+] = 1.25 mM). Energy-yielding substrates were glucose, pyruvate, lactate, and fat...

journal_title：Journal of molecular and cellular cardiology

authors： Bünger R,Swindall B,Brodie D,Zdunek D,Stiegler H,Walter G

更新日期：1986-04-01 00:00:00

abstract：:Acute adriamycin cardiotoxicity was studied in the isolated, perfused rat heart by 31P and 13C NMR spectroscopy at flow rates of 15 and 5 ml/min. Treated hearts received a total dose of 13.5 mg of adriamycin. 31P NMR spectra were collected at the beginning and end of each experiment, and cardiac function was recorded ...

journal_title：Journal of molecular and cellular cardiology

authors： Chatham JC,Cousins JP,Glickson JD

更新日期：1990-10-01 00:00:00

abstract：:Endothelial dysfunction is the earliest pathologic alteration in diabetic vascular injury and plays a critical role in the development of atherosclerosis. Plasma levels of adiponectin (APN), a novel vasculoprotective adipocytokine, are significantly reduced in diabetic patients, but its relationship with endothelial d...

journal_title：Journal of molecular and cellular cardiology

authors： Cao Y,Tao L,Yuan Y,Jiao X,Lau WB,Wang Y,Christopher T,Lopez B,Chan L,Goldstein B,Ma XL

更新日期：2009-03-01 00:00:00

abstract：:Mitochondria-generated reactive oxygen species (ROS) play a crucial role in the pathogenesis of aging and age-associated diseases. In this study, we evaluated the effects of XJB-5-131 (XJB), a mitochondria-targeted ROS and electron scavenger, on cardiac resistance to ischemia-reperfusion (IR)-induced oxidative stress ...

journal_title：Journal of molecular and cellular cardiology

authors： Escobales N,Nuñez RE,Jang S,Parodi-Rullan R,Ayala-Peña S,Sacher JR,Skoda EM,Wipf P,Frontera W,Javadov S

更新日期：2014-12-01 00:00:00

abstract：:Exposure to carbon monoxide (CO) during the fetal and neonatal period was used to evaluate cardiac ventricular regional weight and myocyte growth response to an increased hemodynamic load. Date-mated Sprague-Dawley rats inhaled 200 ppm CO from day 7 of pregnancy until parturition; another group of pregnant rats inhale...

journal_title：Journal of molecular and cellular cardiology

authors： Clubb FJ Jr,Penney DG,Baylerian MS,Bishop SP

更新日期：1986-05-01 00:00:00

abstract：:Autophagy is a process that removes damaged proteins and organelles and is of particular importance in terminally differentiated cells such as cardiomyocytes, where it has primarily a protective role. We investigated the involvement of inositol(1,4,5)trisphosphate (Ins(1,4,5)P(3)) and its receptors in autophagic respo...

journal_title：Journal of molecular and cellular cardiology

authors： Wong A,Grubb DR,Cooley N,Luo J,Woodcock EA

更新日期：2013-01-01 00:00:00

abstract：:The progression of cardiomyopathy to congestive heart failure is often associated with the expression of fetal cardiac-specific genes. In mice, the basic helix-loop-helix transcription factors, dHAND and eHAND, are expressed in a cardiac chamber-specific fashion and are essential for fetal cardiac development, but are...

journal_title：Journal of molecular and cellular cardiology

authors： Natarajan A,Yamagishi H,Ahmad F,Li D,Roberts R,Matsuoka R,Hill S,Srivastava D

更新日期：2001-09-01 00:00:00

abstract：:The heart responds to increased haemodynamic load with growth of the ventricles. The rise in ventricle mass is due to increasing mass of the myocytes and proliferation of fibroblasts and smooth muscle cells. The accompanying adaptation and remodelling of the interstitium, e.g. production and composition of the extrace...

journal_title：Journal of molecular and cellular cardiology

authors： Simm A,Nestler M,Hoppe V

更新日期：1997-01-01 00:00:00

abstract：:Although cardiac failure can develop over time after myocardial infarction, the mechanism responsible for this is still unknown. The change of intracellular Ca2+ transport protein, such as sarcoplasmic reticulum (SR) Ca2+-ATPase (SR-Ca2+), Na+-Ca2+ exchanger (Na+-Ca2+), or cardiac phenotypic modulation of contractile ...

journal_title：Journal of molecular and cellular cardiology

authors： Yoshiyama M,Takeuchi K,Hanatani A,Kim S,Omura T,Toda I,Teragaki M,Akioka K,Iwao H,Yoshikawa J

更新日期：1997-01-01 00:00:00

abstract：:Autophagy is an evolutionarily ancient process of intracellular catabolism necessary to preserve cellular homeostasis in response to a wide variety of stresses. In the case of post-mitotic cells, where cell replacement is not an option, finely tuned quality control of cytoplasmic constituents and organelles is especia...

journal_title：Journal of molecular and cellular cardiology

authors： Schiattarella GG,Hill JA

更新日期：2016-06-01 00:00:00

abstract：:We hypothesized that chronic xanthine oxidase inhibition (XOI) would have favorable effects on both ventricular and vascular performance in evolving heart failure (HF), thereby preserving ventricular-vascular coupling. In HF, XOI reduces oxidative stress and improves both vascular and myocardial function. Dogs were ra...

journal_title：Journal of molecular and cellular cardiology

authors： Amado LC,Saliaris AP,Raju SV,Lehrke S,St John M,Xie J,Stewart G,Fitton T,Minhas KM,Brawn J,Hare JM

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Mitochondrial calcium overload is an important factor in defining ischemia/reperfusion injury. Since pre-menopausal women are relatively protected from ischemia and heart disease, we tested the hypothesis that gender differences alter Ca(2+) handling in rat cardiac mitochondria. METHODS:Using cardiac mitoch...

journal_title：Journal of molecular and cellular cardiology

authors： Arieli Y,Gursahani H,Eaton MM,Hernandez LA,Schaefer S

更新日期：2004-08-01 00:00:00

abstract：:We evaluated the hypothesis that uterine cells home to the heart after injury and improve cardiac outcomes. Premenopausal women have fewer cardiovascular complications than age-matched men, but the mechanisms responsible for this protection have not been conclusively identified. Hysterectomy was performed in young fem...

journal_title：Journal of molecular and cellular cardiology

authors： Xaymardan M,Sun Z,Hatta K,Tsukashita M,Konecny F,Weisel RD,Li RK

更新日期：2012-06-01 00:00:00