The effects of trimetoquinol on the intact rabbit heart and myocardial adenylate cyclase activity: evidence for spare myocardial beta receptors.

abstract：:Cardiac tyhrotropin-releasing hormone (TRH) is overexpressed in the hypertrophied left ventricle (LV) of spontaneously hypertensive rats (SHR) and its inhibition prevents both hypertrophy and fibrosis. In a normal heart, the TRH increase induces fibrosis and hypertrophy opening the question of whether TRH could be a c...

journal_title：Journal of molecular and cellular cardiology

authors： Peres Diaz LS,Schuman ML,Aisicovich M,Toblli JE,Pirola CJ,Landa MS,García SI

更新日期：2018-11-01 00:00:00

abstract：:Aspirin and clopidogrel are used therapeutically for their anti-platelet effects. We examined the effects of aspirin and clopidogrel on basal and beta-adrenoceptor (beta-AR)-mediated platelet nitric oxide (NO) synthesis in healthy subjects and patients with coronary heart disease (CHD). Healthy subjects (n=19) were ra...

journal_title：Journal of molecular and cellular cardiology

authors： O'Kane PD,Reebye V,Ji Y,Stratton P,Jackson G,Ferro A

更新日期：2008-08-01 00:00:00

abstract：:We have demonstrated that scar formation after myocardial infarction (MI) is associated with an endogenous pool of CD44(pos)CD45(neg) multipotential mesenchymal stem cells (MSC). MSC differentiate into fibroblasts secreting collagen that forms a scar and mature into myofibroblasts that express alpha smooth muscle acti...

journal_title：Journal of molecular and cellular cardiology

authors： Cieslik KA,Taffet GE,Crawford JR,Trial J,Mejia Osuna P,Entman ML

更新日期：2013-10-01 00:00:00

abstract：:An increase in circulating brain natriuretic peptide (BNP) but not atrial natriuretic factor (ANF) is observed coincident with cardiac allograft rejection that is reversed upon treatment with anti-lymphocyte therapy suggesting that pro-inflammatory cytokines may uniquely modulate BNP gene expression and secretion. Thi...

journal_title：Journal of molecular and cellular cardiology

authors： Ma KK,Ogawa T,de Bold AJ

更新日期：2004-04-01 00:00:00

abstract：INTRODUCTION:Fibroblast activation protein α (FAP) is a membrane-bound serine protease expressed by activated fibroblasts during wound healing in the skin. Expression of FAP after myocardial infarction (MI) and potential effects on cardiac wound healing are largely unknown. METHODS:MI was induced in rats and FAP expre...

journal_title：Journal of molecular and cellular cardiology

authors： Tillmanns J,Hoffmann D,Habbaba Y,Schmitto JD,Sedding D,Fraccarollo D,Galuppo P,Bauersachs J

更新日期：2015-10-01 00:00:00

abstract：:Mitochondria are highly metabolically active cell organelles that not only act as the powerhouse of the cell by supplying energy through ATP production, but also play a destructive role by initiating cell death pathways. Growing evidence recognizes that mitochondrial dysfunction is one of the major causes of cardiovas...

journal_title：Journal of molecular and cellular cardiology

authors： Das S,Steenbergen C

更新日期：2012-02-01 00:00:00

abstract：:Mitochondria-generated reactive oxygen species (ROS) play a crucial role in the pathogenesis of aging and age-associated diseases. In this study, we evaluated the effects of XJB-5-131 (XJB), a mitochondria-targeted ROS and electron scavenger, on cardiac resistance to ischemia-reperfusion (IR)-induced oxidative stress ...

journal_title：Journal of molecular and cellular cardiology

authors： Escobales N,Nuñez RE,Jang S,Parodi-Rullan R,Ayala-Peña S,Sacher JR,Skoda EM,Wipf P,Frontera W,Javadov S

更新日期：2014-12-01 00:00:00

abstract：:Studies to test whether superoxide dismutase (SOD), with or without catalase, limits myocardial infarct size have produced conflicting results. Positive results following short periods of reperfusion vs negative results following longer periods of reperfusion could be explained if either: (1) myocytes, initially salva...

journal_title：Journal of molecular and cellular cardiology

authors： Tanaka M,Richard VJ,Murry CE,Jennings RB,Reimer KA

更新日期：1993-04-01 00:00:00

abstract：:The effects of variations in serum concentrations of potassium on the occurrence and severity of ischemia- and reperfusion-induced arrhythmias have been studied in conscious rats. Serum potassium concentrations were modified by maintaining rats on diets which varied in potassium concentration, by treatment with hydroc...

journal_title：Journal of molecular and cellular cardiology

authors： Saint KM,Abraham S,MacLeod BA,McGough J,Yoshida N,Walker MJ

更新日期：1992-07-01 00:00:00

abstract：:The ability of different substrates to affect myocardial function is well established but the mechanism for this effect has yet to be determined. To explore this area further, the studies described below were designed to determine the effect of different metabolic substrates, glucose or pyruvate, on myocardial respons...

journal_title：Journal of molecular and cellular cardiology

authors： Snow TR

更新日期：1986-07-01 00:00:00

abstract：:We have recently shown that norepinephrine (NE) pretreatment attenuates Ca2+ overloading in cardiac rat trabeculae during metabolic inhibition (MI) with NaCN (2 mmol/l), and improves contractile recovery during a subsequent recovery period (RP). In the present study, we investigated the effects of the continuous prese...

journal_title：Journal of molecular and cellular cardiology

authors： Musters RJ,van der Meulen ET,van der Laarse WJ,van Hardeveld C

更新日期：1998-02-01 00:00:00

abstract：:Oxygen radical-mediated injury has been implicated in the process of cardiac aging. We investigated the tolerance to oxidative stress of hearts from rats of different age. Langendorff-perfused hearts from 3-12-month-old rats received a 30 min infusion of the reactive oxygen specie hydrogen peroxide (H2O2, 60 microM), ...

journal_title：Journal of molecular and cellular cardiology

authors： Abete P,Napoli C,Santoro G,Ferrara N,Tritto I,Chiariello M,Rengo F,Ambrosio G

更新日期：1999-01-01 00:00:00

abstract：:Cardiomyocyte (CM) proliferative potential varies considerably across species. While lower vertebrates and neonatal mammals retain robust capacities for CM proliferation, adult mammalian CMs lose proliferative potential due to cell-cycle withdrawal and polyploidization, failing to mount a proliferative response to reg...

journal_title：Journal of molecular and cellular cardiology

authors： Cutie S,Payumo AY,Lunn D,Huang GN

更新日期：2020-05-01 00:00:00

abstract：:Peptidyl-prolyl isomerase Pin1 has been reported to be associated with endothelial dysfunction. However, the role of smooth muscle Pin1 in the vascular system remains unclear. Here, we examined the potential function of Pin1 in smooth muscle cells (SMCs) and its contribution to abdominal aortic aneurysm (AAA) pathogen...

journal_title：Journal of molecular and cellular cardiology

authors： Liang ES,Cheng W,Yang RX,Bai WW,Liu X,Zhao YX

更新日期：2018-01-01 00:00:00

abstract：:The leading cause of genetic dilated cardiomyopathy (DCM) is due to mutations in the TTN gene, impacting approximately 15-20% of familial and 18% of sporadic DCM cases. Currently, there is potential for a personalized RNA-based therapeutic approach in titin-based DCM, utilizing antisense oligonucleotide (AON) mediated...

journal_title：Journal of molecular and cellular cardiology

authors： Hahn JK,Neupane B,Pradhan K,Zhou Q,Testa L,Pelzl L,Maleck C,Gawaz M,Gramlich M

更新日期：2019-06-01 00:00:00

abstract：:The existing literature indicates a crucial role of p38 MAP (mitogen-activated protein) kinase (p38MAPK) and its downstream target MAPKAP kinase 2 (MK2) in ischemic preconditioning (IPC). Accordingly, deletion of MK2 gene should abolish the cardioprotective ability of IPC. Interestingly, we were able to partially prec...

journal_title：Journal of molecular and cellular cardiology

authors： Nagy N,Shiroto K,Malik G,Huang CK,Gaestel M,Abdellatif M,Tosaki A,Maulik N,Das DK

更新日期：2007-05-01 00:00:00

abstract：:Interactions between platelets with injured vascular endothelium contribute to thrombotic occlusion. A murine monoclonal antibody [7E3 F(ab')2] to the platelet GPIIb/IIIa receptor complex was used to inhibit platelet aggregation in an experimental model of coronary artery thrombosis. Prevention of thrombotic occlusion...

journal_title：Journal of molecular and cellular cardiology

authors： Mickelson JK,Simpson PJ,Lucchesi BR

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) have great potential as a cell source for therapeutic applications such as regenerative medicine, disease modeling, drug screening, and toxicity testing. This potential is limited, however, by the immature state of the cardiomyocyte...

journal_title：Journal of molecular and cellular cardiology

authors： Yang X,Rodriguez M,Pabon L,Fischer KA,Reinecke H,Regnier M,Sniadecki NJ,Ruohola-Baker H,Murry CE

更新日期：2014-07-01 00:00:00

abstract：:Pacemaker (HCN) channels have a key role in the generation and modulation of spontaneous activity of sinoatrial node myocytes. Previous work has shown that compartmentation of HCN4 pacemaker channels within caveolae regulates important functions, but the molecular mechanism responsible is still unknown. HCN channels h...

journal_title：Journal of molecular and cellular cardiology

authors： Barbuti A,Scavone A,Mazzocchi N,Terragni B,Baruscotti M,Difrancesco D

更新日期：2012-08-01 00:00:00

abstract：:Age-associated cardiovascular diseases are at least partially ascribable to vascular cell senescence. Replicative senescence (RS) and stress-induced premature senescence (SIPS) are provoked respectively by endogenous (telomere erosion) and exogenous (H2O2, UV) stimuli resulting in cell cycle arrest in G1 and G2 phases...

journal_title：Journal of molecular and cellular cardiology

authors： Bianchessi V,Badi I,Bertolotti M,Nigro P,D'Alessandra Y,Capogrossi MC,Zanobini M,Pompilio G,Raucci A,Lauri A

更新日期：2015-04-01 00:00:00

abstract：:Understanding the process of Ca(2+)/Mg(2+)exchange during muscle excitation and relaxation is fundamental to elucidating the mechanism of Ca(2+)-regulated muscle contraction. During the resting phase, the C-domain of cardiac troponin C may be occupied by either Ca(2+)or Mg(2+). Here, complexes of recombinant cardiac t...

journal_title：Journal of molecular and cellular cardiology

authors： Finley N,Dvoretsky A,Rosevear PR

更新日期：2000-08-01 00:00:00

abstract：:Cardiomyocyte progenitor cells (CMPCs) can be isolated from the human heart and differentiated into cardiomyocytes in vitro. A comprehensive assessment of their electrical phenotype upon differentiation is essential to predict potential future applications of this cell source. CMPCs isolated from human fetal heart wer...

journal_title：Journal of molecular and cellular cardiology

authors： de Boer TP,van Veen TA,Jonsson MK,Kok BG,Metz CH,Sluijter JP,Doevendans PA,de Bakker JM,Goumans MJ,van der Heyden MA

更新日期：2010-01-01 00:00:00

abstract：:The insulin receptor substrate (IRS) family plays important roles in cellular growth, signaling, and survival in the brain. We identified IRS6/Dok-5, a member of the IRS family, also expressed in heart. Dok-5 expression level significantly increased during cardiomyocyte differentiation of P19CL6 cells. To understand t...

journal_title：Journal of molecular and cellular cardiology

authors： Wen J,Xia Q,Wang C,Liu W,Chen Y,Gao J,Gong Y,Yin B,Ke Y,Qiang B,Yuan J,Peng X

更新日期：2009-12-01 00:00:00

abstract：:Cardiovascular diseases (CVDs) and renal impairment interact in a complex and interdependent manner, which makes clarification of possible pathogenesis between CVDs and renal diseases very challenging and important. There is increasing evidence showing that both asymmetric dimethylarginine (ADMA) and symmetric dimethy...

journal_title：Journal of molecular and cellular cardiology

authors： Hu XL,Li MP,Song PY,Tang J,Chen XP

更新日期：2017-12-01 00:00:00

abstract：:The effects of cyclopiazonic acid, a specific inhibitor of the sarcoplasmic reticulum Ca(2+)-ATPase, on membrane currents and contraction were investigated under voltage clamped conditions on frog atrial trabeculae using the double mannitol-gap technique. In ringer solution, cyclopiazonic acid (10 microM) decreased th...

journal_title：Journal of molecular and cellular cardiology

authors： Badaoui A,Huchet-Cadiou C,Léoty C

更新日期：1995-11-01 00:00:00

abstract：:Screening for cell surface proteins up-regulated under stress conditions may lead to the identification of new therapeutic targets. To search for genes whose expression was enhanced by treatment with oligomycin, a mitochondrial-F(0)F(1) ATP synthase inhibitor, signal sequence trapping was performed in H9C2 rat cardiac...

journal_title：Journal of molecular and cellular cardiology

authors： Nagao K,Ono K,Iwanaga Y,Tamaki Y,Kojima Y,Horie T,Nishi H,Kinoshita M,Kuwabara Y,Hasegawa K,Kita T,Kimura T

更新日期：2010-06-01 00:00:00

abstract：:Pyroptosis is a pro-inflammatory form of programmed cell death, whose genesis directly depended on caspase-1 activation. Pulmonary hypertension (PH) is a disease characterized, in part, by vascular fibrosis. Up to now, there is no report on the relationship between pyroptosis and vascular fibrosis in PH. Here, we conf...

journal_title：Journal of molecular and cellular cardiology

authors： Zhang M,Xin W,Yu Y,Yang X,Ma C,Zhang H,Liu Y,Zhao X,Guan X,Wang X,Zhu D

更新日期：2020-01-01 00:00:00

abstract：AIMS:During embryogenesis, the onset of circulatory blood flow generates a variety of hemodynamic forces which reciprocally induce changes in cardiovascular development and performance. It has been known for some time that these forces can be detected by as yet unknown mechanosensory systems which in turn promote cardi...

journal_title：Journal of molecular and cellular cardiology

authors： Faucherre A,Moha Ou Maati H,Nasr N,Pinard A,Theron A,Odelin G,Desvignes JP,Salgado D,Collod-Béroud G,Avierinos JF,Lebon G,Zaffran S,Jopling C

更新日期：2020-06-01 00:00:00

abstract：AIMS:Cyclic AMP phosphodiesterases (PDEs) are important modulators of the cardiac response to β-adrenergic receptor (β-AR) stimulation. PDE3 is classically considered as the major cardiac PDE in large mammals and human, while PDE4 is preponderant in rodents. However, it remains unclear whether PDE4 also plays a functio...

journal_title：Journal of molecular and cellular cardiology

authors： Mika D,Bobin P,Lindner M,Boet A,Hodzic A,Lefebvre F,Lechène P,Sadoune M,Samuel JL,Algalarrondo V,Rucker-Martin C,Lambert V,Fischmeister R,Vandecasteele G,Leroy J

更新日期：2019-08-01 00:00:00

abstract：:Fibrosis, which is defined as excessive accumulation of fibrous connective tissue, contributes to the pathogenesis of numerous diseases involving diverse organ systems. Cardiac fibrosis predisposes individuals to myocardial ischemia, arrhythmias and sudden death, and is commonly associated with diastolic dysfunction. ...

journal_title：Journal of molecular and cellular cardiology

authors： Williams SM,Golden-Mason L,Ferguson BS,Schuetze KB,Cavasin MA,Demos-Davies K,Yeager ME,Stenmark KR,McKinsey TA

更新日期：2014-02-01 00:00:00