Rapid, high-level expression of biologically active alpha-trichosanthin in transfected plants by an RNA viral vector.

abstract：:Infants born prematurely risk significant life-long cognitive disability, representing a major pediatric health crisis. The neuropathology of this cohort is accurately modeled in mice subjected to sublethal postnatal hypoxia. Massively parallel transcriptome analysis using cDNA microchips (9,262 genes), combined with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curristin SM,Cao A,Stewart WB,Zhang H,Madri JA,Morrow JS,Ment LR

更新日期：2002-11-26 00:00:00

abstract：:Model compositions of Earth, Venus, and Mercury are calculated from the premise that planets and chondrites underwent four identical fractionation processes in the solar nebula. Because elements of similar properties stay together in these processes, five constraints suffice to define the composition of a planet: mass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morgan JW,Anders E

更新日期：1980-12-01 00:00:00

abstract：:The protein-protein interaction (PPI) network is crucial for cellular information processing and decision-making. With suitable inputs, PPI networks drive the cells to diverse functional outcomes such as cell proliferation or cell death. Here, we characterize the structural controllability of a large directed human PP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vinayagam A,Gibson TE,Lee HJ,Yilmazel B,Roesel C,Hu Y,Kwon Y,Sharma A,Liu YY,Perrimon N,Barabási AL

更新日期：2016-05-03 00:00:00

abstract：:Combining genotypes across datasets is central in facilitating advances in genetics. Data aggregation efforts often face the challenge of record matching-the identification of dataset entries that represent the same individual. We show that records can be matched across genotype datasets that have no shared markers ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edge MD,Algee-Hewitt BFB,Pemberton TJ,Li JZ,Rosenberg NA

更新日期：2017-05-30 00:00:00

abstract：:Replication of complementary-strand DNA in filamentous phages is initiated by a primer RNA that is synthesized at the minus-strand origin on the viral single-stranded DNA by Escherichia coli RNA polymerase holoenzyme containing the sigma70 subunit. We have demonstrated that the affinity of RNA polymerase in vitro to t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higashitani A,Higashitani N,Horiuchi K

更新日期：1997-04-01 00:00:00

abstract：:Epidemiological and genetic association studies show that genetics play an important role in the attainment of education. Here, we investigate the effect of this genetic component on the reproductive history of 109,120 Icelanders and the consequent impact on the gene pool over time. We show that an educational attainm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kong A,Frigge ML,Thorleifsson G,Stefansson H,Young AI,Zink F,Jonsdottir GA,Okbay A,Sulem P,Masson G,Gudbjartsson DF,Helgason A,Bjornsdottir G,Thorsteinsdottir U,Stefansson K

更新日期：2017-01-31 00:00:00

abstract：:To improve the efficiency of liposome-mediated DNA transfer as a tool for gene therapy, we have developed a fusigenic liposome vector based on principles of viral cell fusion. The fusion proteins of hemagglutinating virus of Japan (HVJ; also Sendai virus) are complexed with liposomes that encapsulate oligodeoxynucleot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dzau VJ,Mann MJ,Morishita R,Kaneda Y

更新日期：1996-10-15 00:00:00

abstract：:We report the optical conductivity in high-quality crystals of the chiral topological semimetal CoSi, which hosts exotic quasiparticles known as multifold fermions. We find that the optical response is separated into several distinct regions as a function of frequency, each dominated by different types of quasiparticl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu B,Fang Z,Sánchez-Martínez MÁ,Venderbos JWF,Ni Z,Qiu T,Manna K,Wang K,Paglione J,Bernhard C,Felser C,Mele EJ,Grushin AG,Rappe AM,Wu L

更新日期：2020-11-03 00:00:00

abstract：:The developmental loss of neurons in sympathetic, sensory, and some parasympathetic ganglia in familial dysautonomia suggests an inherited defect in the action of beta-nerve growth factor (beta-NGF). The role of this growth factor in dysautonomia has been difficult to resolve as there is no known source of authentic h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breakefield XO,Orloff G,Castiglione C,Coussens L,Axelrod FB,Ullrich A

更新日期：1984-07-01 00:00:00

abstract：:The spleen from a patient with adult Gaucher's disease was shown to be deficient in a beta-glucosidase (EC 3.2.1.21) isoenzyme that has optimal activity at pH 4.0-4.3, and is stimulated by 0.02% Triton X-100. A mixture of spleen homogenates from a control and from the patient contained beta-glucosidase activity equiva...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho MW,O'Brien JS

更新日期：1971-11-01 00:00:00

abstract：:Ab initio multi-reference second-order perturbation theory computations are used to explore the photochemical behavior of two ion pairs constituted by a chloride counterion interacting with either a rhodopsin or bacteriorhodopsin chromophore model (i.e., the 4-cis-gamma-methylnona-2,4,6,8-tetraeniminium and all-trans-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cembran A,Bernardi F,Olivucci M,Garavelli M

更新日期：2005-05-03 00:00:00

abstract：:Cell-based therapies, using multipotent mesenchymal stem cells (MSCs) for organ regeneration, are being pursued for cardiac disease, orthopedic injuries and biomaterial fabrication. The molecular pathways that regulate MSC-mediated regeneration or enhance their therapeutic efficacy are, however, poorly understood. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alfaro MP,Pagni M,Vincent A,Atkinson J,Hill MF,Cates J,Davidson JM,Rottman J,Lee E,Young PP

更新日期：2008-11-25 00:00:00

abstract：:Interleukin (IL)-15 and its specific receptor chain, IL-15Rα, support the development of various effector cells, including NK and CD8 T cells via a mechanism called trans-presentation. Whereas the dynamic of trans-presentation has been shown to involve the recycling of IL-15Rα by presenting cells, the way responding c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamzalit F,Barbieux I,Plet A,Heim J,Nedellec S,Morisseau S,Jacques Y,Mortier E

更新日期：2014-06-10 00:00:00

abstract：:Previous studies have suggested that most papillomaviruses enter the host cell via clathrin-dependent receptor-mediated endocytosis but have not addressed later steps in viral entry. To examine these events, we followed the localization of L2 and packaged DNA after entry of infectious virions or L1/L2 pseudovirions. C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Day PM,Baker CC,Lowy DR,Schiller JT

更新日期：2004-09-28 00:00:00

abstract：:Sleep is recognized as a physiological state associated with learning, with studies showing that knowledge acquisition improves with naps. Little work has examined sleep-dependent learning in people with developmental disorders, for whom sleep quality is often impaired. We examined the effect of natural, in-home naps ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spanò G,Gómez RL,Demara BI,Alt M,Cowen SL,Edgin JO

更新日期：2018-11-13 00:00:00

abstract：:N-type Ca2+ channels mediate Ca2+ influx, which initiates fast exocytosis of neurotransmitters at synapses, and they interact directly with the SNARE proteins syntaxin and SNAP-25 (synaptosome-associated protein of 25 kDa) through a synaptic protein interaction (synprint) site in the intracellular loop connecting doma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheng ZH,Yokoyama CT,Catterall WA

更新日期：1997-05-13 00:00:00

abstract：:The HIV type 1 (HIV-1) virion infectivity factor (Vif) protein blocks the action of the host defense factor APOBEC3G in human cells, thereby allowing release of infectious virions, but fails to inhibit similar APOBEC3G proteins present in some simian cells. Conversely, the Vif protein encoded by the African green monk...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bogerd HP,Doehle BP,Wiegand HL,Cullen BR

更新日期：2004-03-16 00:00:00

abstract：:Uncoupling protein 1 (UCP1) catalyzes fatty acid-activated, purine nucleotide-sensitive proton leak across the mitochondrial inner membrane of brown adipose tissue to produce heat, and could help combat obesity and metabolic disease in humans. Studies over the last 30 years conclude that the protein is a dimer, bindin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee Y,Willers C,Kunji ER,Crichton PG

更新日期：2015-06-02 00:00:00

abstract：:Rad51 is the primary eukaryotic recombinase responsible for initiating DNA strand exchange during homologous recombination. Although the subject of intense study for over a decade, many molecular details of the reactions promoted by Rad51 and related recombinases remain unknown. Using total internal reflection fluores...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Granéli A,Yeykal CC,Robertson RB,Greene EC

更新日期：2006-01-31 00:00:00

abstract：:Sialic acid-recognizing Ig-like lectins (Siglecs) are signaling receptors that modulate immune responses, and are targeted for interactions by certain pathogens. We describe two primate Siglecs that were rendered nonfunctional by single genetic events during hominin evolution after our common ancestor with the chimpan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Mitra N,Secundino I,Banda K,Cruz P,Padler-Karavani V,Verhagen A,Reid C,Lari M,Rizzi E,Balsamo C,Corti G,De Bellis G,Longo L,NISC Comparative Sequencing Program.,Beggs W,Caramelli D,Tishkoff SA,Hayakawa T,Gree

更新日期：2012-06-19 00:00:00

abstract：:An in-depth knowledge of the interaction of water with amorphous silica is critical to fundamental studies of interfacial hydration water, as well as to industrial processes such as catalysis, nanofabrication, and chromatography. Silica has a tunable surface comprising hydrophilic silanol groups and moderately hydroph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schrader AM,Monroe JI,Sheil R,Dobbs HA,Keller TJ,Li Y,Jain S,Shell MS,Israelachvili JN,Han S

更新日期：2018-03-20 00:00:00

abstract：:Colon carcinoma is one of the leading causes of death from cancer and is characterized by a heterogenic pool of cells with distinct differentiation patterns. Recently, it was reported that a population of undifferentiated cells from a primary tumor, so-called cancer stem cells (CSC), can reconstitute the original tumo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vermeulen L,Todaro M,de Sousa Mello F,Sprick MR,Kemper K,Perez Alea M,Richel DJ,Stassi G,Medema JP

更新日期：2008-09-09 00:00:00

abstract：:We consider the sequential estimation of p, the probability of success in an infinite sequence of Bernoulli trials, when the loss incurred in stopping after n trials and estimating p by some function delta(n) of the first n outcomes is taken to be [Formula: see text] The loss due to error of estimation is thus the sym...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cabilio P,Robbins H

更新日期：1975-01-01 00:00:00

abstract：:The het-s locus of Podospora anserina is a heterokaryon incompatibility locus. The coexpression of the antagonistic het-s and het-S alleles triggers a lethal reaction that prevents the formation of viable heterokaryons. Strains that contain the het-s allele can display two different phenotypes, [Het-s] or [Het-s*], ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coustou V,Deleu C,Saupe S,Begueret J

更新日期：1997-09-02 00:00:00

abstract：:The superficial gray layer of the superior colliculus contains a map that represents the visual field, whereas the underlying intermediate gray layer contains a vector map of the saccades that shift the direction of gaze. These two maps are aligned so that a particular region of the visual field is represented directl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee PH,Helms MC,Augustine GJ,Hall WC

更新日期：1997-11-25 00:00:00

abstract：:How much free energy is irreversibly lost during a thermodynamic process? For deterministic protocols, lower bounds on energy dissipation arise from the thermodynamic friction associated with pushing a system out of equilibrium in finite time. Recent work has also bounded the cost of precisely moving a single degree o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bryant SJ,Machta BB

更新日期：2020-02-18 00:00:00

abstract：:The genomic RNA of the avian influenza A virus, fowl plague, was fractionated into eight species by electrophoresis in polyacrylamide-agarose gels containing 6 M urea. The separated 32P-labeled RNA species were characterized by digestion with RNase T1 and fractionation of the resulting oligonucleotides by two-dimensio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGeoch D,Fellner P,Newton C

更新日期：1976-09-01 00:00:00

abstract：:Studies to elucidate the mode of action of aldosterone have been carried out in the amphibian urinary bladder. The following previously reported hypotheses were evaluated: (1) aldosterone stimulates sodium transport by increasing the amount of sodium available to the sodium pump; (2) aldosterone enhances energy produc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodman DB,Allen JE,Rasmussen H

更新日期：1969-09-01 00:00:00

abstract：:Short oxygen-halogen interactions have been known in organic chemistry since the 1950s and recently have been exploited in the design of supramolecular assemblies. The present survey of protein and nucleic acid structures reveals similar halogen bonds as potentially stabilizing inter- and intramolecular interactions t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Auffinger P,Hays FA,Westhof E,Ho PS

更新日期：2004-11-30 00:00:00

abstract：:Seemingly similar individuals often experience drastically different success trajectories, with some repeatedly failing and others consistently succeeding. One explanation is preexisting variability along unobserved fitness dimensions that is revealed gradually through differential achievement. Alternatively, positive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van de Rijt A,Kang SM,Restivo M,Patil A

更新日期：2014-05-13 00:00:00