HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.

abstract：:In this study, we demonstrate that fluid shear stress (FSS)-induced actin cytoskeletal reorganization and junctional formation in renal epithelial cells are nearly completely opposite the corresponding changes in vascular endothelial cells (ECs) [Thi MM et al. (2004) Proc Natl Acad Sci USA 101:16483-16488]. Mouse prox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duan Y,Gotoh N,Yan Q,Du Z,Weinstein AM,Wang T,Weinbaum S

更新日期：2008-08-12 00:00:00

abstract：:Temperate-zone species have responded to warming temperatures by shifting their distributions poleward and upslope. Thermal tolerance data suggests that tropical species may respond to warming temperatures even more strongly than temperate-zone species, but this prediction has yet to be tested. We addressed this data ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freeman BG,Class Freeman AM

更新日期：2014-03-25 00:00:00

abstract：:Photoreceptors of the Xenopus laevis retina are the site of a circadian clock. As part of a differential display screen for rhythmic gene products in this system, we have identified a photoreceptor-specific mRNA expressed in peak abundance at night. cDNA cloning revealed an open reading frame encoding a putative 388 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green CB,Besharse JC

更新日期：1996-12-10 00:00:00

abstract：:Histone methylation has an important role in transcriptional regulation. However, unlike H3K4 and H3K9 methylation, the role of H4K20 monomethylation (H4K20me-1) in transcriptional regulation remains unclear. Here, we show that Wnt3a specifically stimulates H4K20 monomethylation at the T cell factor (TCF)-binding elem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Z,Nie F,Wang S,Li L

更新日期：2011-02-22 00:00:00

abstract：:Emotional responses, such as fear and anxiety, are fundamentally important behavioral phenomena with strong fitness components in most animal species. Anxiety-related disorders continue to represent a major unmet medical need in our society, mostly because we still do not fully understand the mechanisms of these disea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi JH,Jeong YM,Kim S,Lee B,Ariyasiri K,Kim HT,Jung SH,Hwang KS,Choi TI,Park CO,Huh WK,Carl M,Rosenfeld JA,Raskin S,Ma A,Gecz J,Kim HG,Kim JS,Shin HC,Park DS,Gerlai R,Jamieson BB,Kim JS,Iremonger KJ,Lee S

更新日期：2018-01-30 00:00:00

abstract：:E2F is a heterodimeric transcription factor that regulates the expression of genes at the G1/S boundary and is composed of two related but distinct families of proteins, E2F and DP. E2F/DP heterodimers form complexes with the retinoblastoma (Rb) protein, the Rb-related proteins p107 and p130, and cyclins/cdks in a cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogers KT,Higgins PD,Milla MM,Phillips RS,Horowitz JM

更新日期：1996-07-23 00:00:00

abstract：:Examples of finite-dimensional Hopf algebras over a field, whose antipodes have arbitrary even orders >/=4 as mappings, are furnished. The dimension of the Hopf algebra is q(n+1), where the antipode has order 2q, q >/= 2, and n is an arbitrary positive integer. The algebras are not semisimple, and neither they nor the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taft EJ

更新日期：1971-11-01 00:00:00

abstract：:As part of a study into the molecular basis of attenuation and reversion to neurovirulence in the Sabin poliovirus vaccines, we have determined the complete nucleotide sequence of a cloned DNA copy of the genome of P3/Leon/37, the neurovirulent progenitor of the type 3 Sabin vaccine strain, P3/Leon 12a1b. Comparison o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stanway G,Hughes PJ,Mountford RC,Reeve P,Minor PD,Schild GC,Almond JW

更新日期：1984-03-01 00:00:00

abstract：:In mammals and insects, pheromones strongly influence social behaviors such as aggression and mate recognition. In Drosophila melanogaster, pheromones in the form of cuticular hydrocarbons play prominent roles in courtship. GC/MS is the primary analytical tool currently used to study Drosophila cuticular hydrocarbons....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yew JY,Cody RB,Kravitz EA

更新日期：2008-05-20 00:00:00

abstract：:Bovine milk lipoprotein lipase was subjected to amino acid sequence analysis. The first 19 amino-terminal residues were Asp-Arg-Ile-Thr-Gly-Gly-Lys-Asp-Phe-Arg-Asp-Ile-Glu-Ser-Lys-Phe-Ala-Leu- Arg. In addition, reversed-phase high-performance liquid chromatography of a tryptic digest of reduced and alkylated lipase re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ben-Avram CM,Ben-Zeev O,Lee TD,Haaga K,Shively JE,Goers J,Pedersen ME,Reeve JR Jr,Schotz MC

更新日期：1986-06-01 00:00:00

abstract：:To assess the effect of transforming growth factor beta 1 on the skin in vivo, we have targeted its expression to the epidermis of transgenic mice. To ensure that active TGF-beta 1 was expressed, we used a porcine TGF-beta 1 cDNA with mutations of Cys-223-->Ser and Cys-225-->Ser, which allow constitutive activation. M...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sellheyer K,Bickenbach JR,Rothnagel JA,Bundman D,Longley MA,Krieg T,Roche NS,Roberts AB,Roop DR

更新日期：1993-06-01 00:00:00

abstract：:Eukaryote cell division features a chromosome compaction-decompaction cycle that is synchronized with their physical and topological segregation. It has been proposed that lengthwise compaction of chromatin into mitotic chromosomes via loop extrusion underlies the compaction-segregation/resolution process. We analyze ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brahmachari S,Marko JF

更新日期：2019-12-10 00:00:00

abstract：:A serpin was identified in normal mammary gland by differential cDNA sequencing. In situ hybridization has detected this serpin exclusively in the myoepithelial cells on the normal and noninvasive mammary epithelial side of the basement membrane and thus was named myoepithelium-derived serine proteinase inhibitor (MEP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao G,Liu YE,Gentz R,Sang QA,Ni J,Goldberg ID,Shi YE

更新日期：1999-03-30 00:00:00

abstract：:The extracellular matrix (ECM) is an intricate network composed of an array of macromolecules capable of regulating the functional responsiveness of cells. Its composition greatly varies among different types of tissue, and dysregulation of its metabolism may contribute to vascular remodeling during the pathogenesis o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roth M,Eickelberg O,Kohler E,Erne P,Block LH

更新日期：1996-05-28 00:00:00

abstract：:The programmed activation/repression of transcription factors in early hematopoietic differentiation has not yet been explored. The DNA-binding protein GATA-1 is required for normal erythroid development and regulates erythroid-expressed genes in maturing erythroblasts. We analyzed GATA-1 expression in early human adu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sposi NM,Zon LI,Carè A,Valtieri M,Testa U,Gabbianelli M,Mariani G,Bottero L,Mather C,Orkin SH

更新日期：1992-07-15 00:00:00

abstract：:Several polymorphisms of the transcription factor 4 (TCF4) have been shown to increase the risk for schizophrenia, particularly TCF4 rs9960767. This polymorphism is associated with impaired sensorimotor gating measured by prepulse inhibition--an established endophenotype of schizophrenia. We therefore investigated whe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quednow BB,Brinkmeyer J,Mobascher A,Nothnagel M,Musso F,Gründer G,Savary N,Petrovsky N,Frommann I,Lennertz L,Spreckelmeyer KN,Wienker TF,Dahmen N,Thuerauf N,Clepce M,Kiefer F,Majic T,Mössner R,Maier W,Gallinat J,D

更新日期：2012-04-17 00:00:00

abstract：:Volumetric detection and accurate quantification of fluorescent proteins in entire animals would greatly enhance our ability to monitor biological processes in vivo. Here we present a quantitative tomographic technique for visualization of superficial and deep-seated (>2-3 mm) fluorescent protein activity in vivo. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zacharakis G,Kambara H,Shih H,Ripoll J,Grimm J,Saeki Y,Weissleder R,Ntziachristos V

更新日期：2005-12-20 00:00:00

abstract：:A recently discovered family of natural anion channelrhodopsins (ACRs) have the highest conductance among channelrhodopsins and exhibit exclusive anion selectivity, which make them efficient inhibitory tools for optogenetics. We report analysis of flash-induced absorption changes in purified wild-type and mutant ACRs,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sineshchekov OA,Li H,Govorunova EG,Spudich JL

更新日期：2016-04-05 00:00:00

abstract：:In everyday life, a macroscopic valve is a device with a movable control element that regulates the flow of gases or liquids by blocking and opening passageways. Construction of such a device on the nanoscale level requires (i) suitably proportioned movable control elements, (ii) a method for operating them on demand,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nguyen TD,Tseng HR,Celestre PC,Flood AH,Liu Y,Stoddart JF,Zink JI

更新日期：2005-07-19 00:00:00

abstract：:Wnt/β-catenin signaling controls development and adult tissue homeostasis by regulating cell proliferation and cell fate decisions. Wnt binding to its receptors Frizzled (FZD) and low-density lipoprotein-related 6 (LRP6) at the cell surface initiates a signaling cascade that leads to the transcription of Wnt target ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerlach JP,Jordens I,Tauriello DVF,van 't Land-Kuper I,Bugter JM,Noordstra I,van der Kooij J,Low TY,Pimentel-Muiños FX,Xanthakis D,Fenderico N,Rabouille C,Heck AJR,Egan DA,Maurice MM

更新日期：2018-04-24 00:00:00

abstract：:Chronic, low grade, sterile inflammation frequently accompanies aging and age-related diseases. Cellular senescence is associated with the production of proinflammatory chemokines, cytokines, and extracellular matrix (ECM) remodeling proteases, which comprise the senescence-associated secretory phenotype (SASP). We fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu M,Tchkonia T,Ding H,Ogrodnik M,Lubbers ER,Pirtskhalava T,White TA,Johnson KO,Stout MB,Mezera V,Giorgadze N,Jensen MD,LeBrasseur NK,Kirkland JL

更新日期：2015-11-17 00:00:00

abstract：:Although tumor necrosis factor (TNF) initially came to prominence because of its anti-tumor activity, most attention is now focused on its proinflammatory actions. TNF appears to play a critical role in both early and late events involved in inflammation, from localizing the noxious agent and amplifying the cellular a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marino MW,Dunn A,Grail D,Inglese M,Noguchi Y,Richards E,Jungbluth A,Wada H,Moore M,Williamson B,Basu S,Old LJ

更新日期：1997-07-22 00:00:00

abstract：:Using GFP to mark recent thymic emigrants (RTEs) in mice carrying a GFP transgene driven by the recombination-activating gene 2 promoter, we demonstrate that RTEs are readily detectable even in 2-year-old mice, despite the fact that the proportion of the peripheral T cell pool comprised of RTEs declines with age. Alth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hale JS,Boursalian TE,Turk GL,Fink PJ

更新日期：2006-05-30 00:00:00

abstract：:High vein density, a distinctive trait of C4 leaves, is central to both C3-to-C4 evolution and conversion of C3 to C4-like crops. We tested the hypothesis that high vein density in C4 leaves is due to elevated auxin biosynthesis and transport in developing leaves. Up-regulation of genes in auxin biosynthesis pathways ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang CF,Yu CP,Wu YH,Lu MJ,Tu SL,Wu SH,Shiu SH,Ku MSB,Li WH

更新日期：2017-08-15 00:00:00

abstract：:The retrosplenial cortex (RSC) is part of a network of interconnected cortical, hippocampal, and thalamic structures harboring spatially modulated neurons. The RSC contains head direction cells and connects to the parahippocampal region and anterior thalamus. Manipulations of the RSC can affect spatial and contextual ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Czajkowski R,Jayaprakash B,Wiltgen B,Rogerson T,Guzman-Karlsson MC,Barth AL,Trachtenberg JT,Silva AJ

更新日期：2014-06-10 00:00:00

abstract：:Two molecular forms of pyrophosphate-dependent phosphofructokinase (PP(i)-PFK; pyrophosphate:D-fructose-6-phosphate 1-phosphotransferase; EC 2.7.1.90) have been found whose activity depends upon association and dissociation characteristics regulated by fructose 2,6-bisphosphate (Fru-2,6-P(2)). PP(i)-PFK was purified 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu MX,Smyth DA,Black CC

更新日期：1984-08-01 00:00:00

abstract：:After pollen grains germinate on the stigma, pollen tubes traverse the extracellular matrix of the style on their way to the ovules. We previously characterized two pollen-specific, receptor-like kinases, LePRK1 and LePRK2, from tomato (Lycopersicon esculentum). Their structure and immunolocalization pattern and the s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wengier D,Valsecchi I,Cabanas ML,Tang WH,McCormick S,Muschietti J

更新日期：2003-05-27 00:00:00

abstract：:Real-world studies show that the facial expressions produced during pain and orgasm-two different and intense affective experiences-are virtually indistinguishable. However, this finding is counterintuitive, because facial expressions are widely considered to be a powerful tool for social interaction. Consequently, de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen C,Crivelli C,Garrod OGB,Schyns PG,Fernández-Dols JM,Jack RE

更新日期：2018-10-23 00:00:00

abstract：:Specific rabbit antisera against purified bovine pituitary carboxypeptidase processing enzyme (which has also been referred to as "enkephalin convertase") have been prepared and characterized. The antisera recognized both the purified soluble and the membrane-bound forms of the enzyme with equal affinity, suggesting t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hook VY,Mezey E,Fricker LD,Pruss RM,Siegel RE,Brownstein MJ

更新日期：1985-07-01 00:00:00

abstract：:The ability to identify sequences in a randomly encoded polypeptide library that are capable of acquiring unique and stably folded structures would be valuable in the examination of protein-folding issues. The quality control system of the yeast secretory pathway prevents the release of incompletely folded polypeptide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagihara Y,Kim PS

更新日期：2002-05-14 00:00:00