当前位置： SCI文献检索 > EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS期刊下所有文献 > Effect of induced hypoalbuminemia on distribution, total clearance and unbound clearance of piroxicam in vivo in the rat.

Effect of induced hypoalbuminemia on distribution, total clearance and unbound clearance of piroxicam in vivo in the rat.

Abstract：

:The influence of decreased albumin concentration on the pharmacokinetic behaviour of Piroxicam was studied in vivo in rats that had undergone plasmapheresis. Reductions of approximately 25% and 50% in the plasma albumin concentration were achieved, the former in rats not given plasma expander, the latter in animals given Ficol-70 as a plasma expander. The unbound fraction of Piroxicam in plasma and the apparent volume of distribution at steady state experienced a statistically significant increase where the albumin concentration was reduced. The average total plasma clearance rose with the increase in fu, between the control (6.3 +/- 2.4 ml/h) and plasmapheretic groups (11.1 +/- 4 ml/h), in accordance with predictions of the 'well-stirred' and 'parallel-tube' models, but no statistically significant differences were found between the two groups, perhaps because of the great interindividual variability associated with this parameter. The total plasma clearance value of the Ficol group (5.4 +/- 2.2 ml/h) was close to that of the control group, despite the high increase in the unbound fraction in plasma. Alterations in the uptake process in the liver due to the high level of induced hypoalbuminemia may have occurred.

journal_name

Eur J Drug Metab Pharmacokinet

journal_title

European journal of drug metabolism and pharmacokinetics

authors

Troconiz JI,Lopez-Bustamante LG,Fos D

doi

10.1007/BF03188792

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

165-71

issue

2

eissn

0378-7966

issn

2107-0180

journal_volume

18

pub_type

杂志文章

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