Chemical substance kinetics in the case of chronobiological variations of elimination rate.

abstract：BACKGROUND AND OBJECTIVES:The disposition of azithromycin in the human eye following topical administration has not been fully explored. Population pharmacokinetic (PopPK) modeling can allow useful conclusions to be drawn based on limited tear sampling data. The aim of this study was therefore to develop and evaluate a...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Wu F,Zhao X,Li X,Cui Y

更新日期：2019-06-01 00:00:00

abstract：:A major biotransformation pathway for many NSAIDs from the group of optically active 2-arylpropionic acids is the conjugation with D-glucuronic acid, forming diastereomers. These conjugates of the S-(+)-and the R-(-)-enantiomers can be separated directly, e.g., by ion-pair chromatography on a C18-column using a mixtur...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Spahn H,Iwakawa S,Bevet LZ,Lin ET

更新日期：1987-10-01 00:00:00

abstract：:Cytochrome P450-dependent enzymes from wheat catalyze the oxidation of endogenous compounds (lauric and oleic acids) and of several herbicides (diclofop, chlortoluron, bentazon). Treatment of wheat seedlings with the safener, naphthalic anhydride and with phenobarbital increases dramatically several P450-dependent enz...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Forthoffer N,Helvig C,Dillon N,Benveniste I,Zimmerlin A,Tardif F,Salaün JP

更新日期：2001-01-01 00:00:00

abstract：:Hepatic distributional volumes were investigated in the in situ perfused rat liver. Perfusion experiments were conducted using Krebs bicarbonate buffer delivered via the portal vein in single-pass mode at a total flow rate of 15 mL/min. A bolus dose of normal erythrocytes (RBC, vascular marker) and Evans blue (EB, ext...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Karabey Y,Sahin S

更新日期：2006-10-01 00:00:00

abstract：:Following i.v. administration of mono-HR to the beagle, plasma levels of both mono-HR and its glucuronide conjugates fell rapidly, neither being detectable 8 h after injection. Following oral administration of 14C-mono-HR, mono-HR-glucuronide was detected in plasma, confirming the absorption of mono-HR, and low levels...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hackett AM,Griffiths LA

更新日期：1979-01-01 00:00:00

abstract：:The present investigation was designed and undertaken in order to substantiate further contention concerning the universality of the utilization of PEG polymers as matrix carriers. This study could then be considered an attempt to enhance the dissolution rate of triamterene, with the subsequent enhancement in its abso...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Arias MJ,Gines JM,Moyano JR,Perez-Barrales MJ,Vela MT,Rabasco AM

更新日期：1994-10-01 00:00:00

abstract：:Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral (intragastric) cyclosporine A (CyA). Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. The factors responsib...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Schück O,Bohdanecká M,Sedivý J,Krajícková M,Chadimová M,Matousovic K

更新日期：1997-07-01 00:00:00

abstract：:Fucithalmic is a newly developed 1% microcrystalline suspension of the antistaphylococcal antibiotic fusidic acid. Penetration into the eye was investigated in twenty patients about to undergo cataract extraction. A single dose produced median antibiotic levels in the aqueous humour of 0.3 mcg/ml, maintained for at le...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hansen S

更新日期：1985-10-01 00:00:00

abstract：:The metabolism of galanthamine hydrobromide (Nivalin) was investigated in rat and rabbit liver homogenates. Experiments were carried out varying several parameters of incubation: substrate (galanthamine hydrobromide, galanthamine, galanthaminone and epigalanthamine), cofactor enrichment (NADPH, NADP/G-6-P, NAD), pH (7...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Mihailova D,Velkov M,Zhivkova Z

更新日期：1987-01-01 00:00:00

abstract：:The transdermally applied dopamine receptor agonist rotigotine is extensively metabolized in the liver. An open-label, parallel-group study was conducted to evaluate the effects of moderate hepatic impairment on the pharmacokinetics, safety and tolerability of rotigotine. Eight subjects with normal hepatic function an...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Cawello W,Fichtner A,Boekens H,Braun M

更新日期：2014-09-01 00:00:00

abstract：:Guizhi decoction (GZD) is a classic traditional Chinese medicine formula, clinically used for the treatment of influenza, common cold, and other pyretic conditions. A sensitive, specific, and validated liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed to investigate the pharmacokinetic pr...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Chen Y,Gao C,Ma Y,Qiu F

更新日期：2013-12-01 00:00:00

abstract：:The aim of this study was to investigate by HPLC the in vivo metabolism of 2-[1'-phenyl-3'-(3-chlorophenyl)-2'-propenylyden]hydrazino-3-methyl-4(3H)-quinazolinone as a substrate, and as a model compound in rats. The substrate was dissolved in DMSO/water (1:4) and administered intraperitoneally at a dose of 100 mg/kg i...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Kaymakçioğlu BK,Aktan Y,Süzen S,Gökhan N,Koyunoğlu S,Erol K,Yeşilada A,Rollas S

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:A clinical trial was conducted to measure and analyse the pharmacokinetic parameters of a lipid formulation of risperidone, VAL401. The VAL401 formulation is designed to repurpose risperidone from an antipsychotic to an adenocarcinoma treatment, with the lipid formulation altering the cellular...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Dilly SJ,Morris GS,Taylor PC,Parmentier F,Williams C,Afshar M

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Sorafenib is an oral, multikinase inhibitor with established single-agent activity in several tumor types. Sorafenib was moderately transported by P-glycoprotein (P-gp) and more efficiently by breast cancer resistance protein. The constitutive androstane receptor (CAR) is a ligand-activated tra...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Karbownik A,Stanisławiak-Rudowicz J,Stachowiak A,Romański M,Grześkowiak E,Szałek E

更新日期：2020-12-01 00:00:00

abstract：:Permeability coefficients of seven compounds belonging to a true homologous series (4-alkylanilines) through several different synthetic and biological membranes were assayed in a two-chamber diffusion cell. Permeability-lipophilicity relationships for the experimental data were established and compared in order to as...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Díez-Sales O,Guzmán D,Cano D,Martín A,Sánchez E,Herráez M

更新日期：1991-01-01 00:00:00

abstract：:The pharmacokinetics of lisuride hydrogen maleate (LHM) were investigated in rat, rabbit and rhesus monkey. Experiments were designed to meet not only the requirements of drug registration but also to serve other preclinical disciplines (toxicology, pharmacology). LHM is absorbed almost completely at a dose level of 1...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Humpel M,Toda T,Oshino N,Pommerenke G

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Methyl 3,4-dihydroxybenzoate (MDHB) has the potential to prevent neurodegenerative diseases (NDDs). The present work aims to reveal the pharmacokinetics and tissue distribution characteristics of MDHB. METHODS:The pharmacokinetics and tissue distribution of MDHB were analyzed using LC-MS/MS a...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Wang JH,Hu SH,Su JY,Pan JP,Mi XN,Geng HJ,Zhang W,Cai L,Su CF,Hong AH,Luo HM

更新日期：2019-04-01 00:00:00

abstract：:The absorption, disposition, biotransformation and excretion of the nonsteroidal anti-inflammatory drug pirazolac were investigated in 6 volunteers (3 males, 3 females, age 50 greater than years) after intravenous and oral administration of 50 mg 14C-pirazolac as an aqueous solution of the sodium salt. Pirazolac was v...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Täuber U,Weiss C,Krause W,Acksteiner B,Matthes H

更新日期：1985-01-01 00:00:00

abstract：:The influence of decreased albumin concentration on the pharmacokinetic behaviour of Piroxicam was studied in vivo in rats that had undergone plasmapheresis. Reductions of approximately 25% and 50% in the plasma albumin concentration were achieved, the former in rats not given plasma expander, the latter in animals gi...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Troconiz JI,Lopez-Bustamante LG,Fos D

更新日期：1993-04-01 00:00:00

abstract：:The kinetics of fenfluramine isomers were studied in the rat following oral doses of racemic fenfluramine. The data, analyzed using an analogue computer, indicate that the d-fenfluramine is metabolised and excreted at a slower rate than the 1-isomer, resulting in higher plasma and brain concentrations. The kinetic par...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Caccia S,Dagnino G,Garattini S,Guiso G,Madonna R,Zanini MG

更新日期：1981-01-01 00:00:00

abstract：:The effect of exogenous coenzyme Q10 (CoQ10) on the pharmacokinetic profiles and biliary excretion of doxorubicin and its main metabolites, doxorubicinol and doxorubicinolone, was investigated in rats. No statistically significant changes in the pharmacokinetic parameters of doxorubicin was observed following the intr...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zhou Q,Chowbay B

更新日期：2002-07-01 00:00:00

abstract：:Relative bioavailability of cisapride was investigated after oral administration of a test versus a reference formulation of immediate release tablets of cisapride, both with 10 mg per unit. The study was conducted in a two-way cross-over design, as a single dose open-label randomised trial. The two formulations were ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Maya MT,Domingos CR,Guerreiro MT,Filipe AP,Morais JA

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Chalcone constitutes one of the most used molecular frameworks in medicinal chemistry and its derivatives exhibit a broad spectrum of biological activities. Low absolute bioavailability, poor distribution, intensive metabolism and elimination of chalcones are the main problems in designing new...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Okoniewska K,Konieczny MT,Lemke K,Grabowski T

更新日期：2017-02-01 00:00:00

abstract：:The present study was carried out to find the in vivo performance of guar gum-based colon-targeted tablets of metronidazole as compared to an immediate release tablets in human volunteers. Six healthy volunteers participated in the study and a crossover design was used. Blood samples were obtained at different time in...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Krishnaiah YS,Veer Raju P,Dinesh Kumar B,Jayaram B,Rama B,Raju V,Bhaskar P

更新日期：2003-10-01 00:00:00

abstract：:The aim of the present study was to investigate the relative bioavailability and bioequivalence of a new tablet formulation of metformin hydrochloride with reference to a standard product in healthy Chinese adult male volunteers. Two randomized, comparative, two-way crossover studies were therefore conducted. In study...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Li J,Jin Y,Wang TY,Lü XW,Li YH

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Clopidogrel is an antiplatelet and antithrombotic prodrug. It has poor oral bioavailability due to poor dissolution and possible premature degradation in the intestine. Accordingly, the objective of this study was to enhance clopidogrel dissolution rate and to reduce its premature degradation ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Bali DE,Osman MA,El Maghraby GM

更新日期：2016-12-01 00:00:00

abstract：:We have studied the metabolism of doxorubicin in rat and mouse liver, heart and hepatocytes. Doxorubicinol was present in all cases at very low levels and 7-deoxyaglycones were present only in extraphysiological conditions: no aglycones were found either in fresh livers or in hearts of animals treated with the drug, b...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Vrignaud P,Londos-Gagliardi D,Robert J

更新日期：1986-04-01 00:00:00

abstract：:Astragalus injection (AI) and Astragalus granules (AG) are the two representative clinical preparations from Astragali Radix. In order to investigate the regulation of metabolism, AI and AG were tested for their ability to affect the major enzyme cytochrome P450 3A isoforms in vivo and in vitro. In the study of CYP3A1...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zhang Y,Huang L,Bi H,Cui Y,Li J,Wang X,Qin X,Chen J,Huang M

更新日期：2013-06-01 00:00:00

abstract：:Using in vitro dissolution and in vivo absorption of different generics or batches for an appropriate drug and dosage form, a reference equation of form: ka = a+bkd+dkd2 can be proposed. In the case of availability of standardised in vitro-in vivo data for a specific drug, a Level A a correlation of this type containi...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Kayali A

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In the present work, pharmacological and pharmacokinetic properties of the supramolecular complex of non-steroid anti-inflammatory drug ibuprofen (IBU) with natural polysaccharide arabinogalactan (AG) were studied. The main goals of such complexation were the increase of ibuprofen's bioavailab...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Khvostov MV,Borisov SA,Tolstikova TG,Dushkin AV,Tsyrenova BD,Chistyachenko YS,Polyakov NE,Dultseva GG,Onischuk AA,An'kov SV

更新日期：2017-06-01 00:00:00