Abstract:
:Previous studies have demonstrated that treatment of fibroblasts from confluent, density-inhibited cultures with 50 mM KCl solution led to the onset of DNA replication. In the present study we show that such treatment can induce aphidicolin-sensitive DNA replication in differentiated nondividing cells: dorsal root ganglia neurons and in vitro differentiated myotubes formed by L6 myoblasts. Murine peritoneal macrophages and macrophages/granulocytes derived from human promyelocytic leukemia cells HL60 are refractory to high potassium treatment. These results confirm the nonuniformity of the nonproliferative state of various differentiated cells.
journal_name
Exp Cell Resjournal_title
Experimental cell researchauthors
Fedorov YV,Prudovsky IA,Yegorov YE,Zelenin AVdoi
10.1006/excr.1993.1296subject
Has Abstractpub_date
1993-11-01 00:00:00pages
156-9issue
1eissn
0014-4827issn
1090-2422pii
S0014-4827(83)71296-6journal_volume
209pub_type
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