Abstract:
OBJECTIVE:To determine whether pancreas transplantation alters lipid and lipoprotein concentrations and whether peripheral hyperinsulinemia is always associated with altered lipid levels. DESIGN:We assessed the lipid profiles of seven pancreas-kidney recipients with insulin-dependent diabetes mellitus, seven kidney recipients without diabetes who received the same immunosuppressive agents, and eight normal subjects. MATERIAL AND METHODS:In the three study groups, fasting and postprandial plasma glucose, insulin, C-peptide, cholesterol, triglyceride, free fatty acid, and apolipoprotein A-I, A-II, C-II, and C-III concentrations were determined. RESULTS:Fasting and postprandial glucose concentrations did not differ between the two transplant groups; however, peripheral insulin concentrations were twice as high (P < 0.05) in the pancreas-kidney recipients as in the kidney recipients both before (102 +/- 15 versus 53 +/- 6 pmol/L) and after (123 +/- 22 versus 61 +/- 6 nmol/L per 6 hours) ingestion of a meal. Preprandial and postprandial insulin levels in both transplant groups also were greater (P < 0.05) than those in normal subjects (35 +/- 6 pmol/L and 40 +/- 7 nmol/L per 6 hours, respectively). Despite significant differences in insulin concentrations, no differences were noted in total cholesterol, high-density or low-density lipoprotein cholesterol, plasma free fatty acids, or apolipoprotein A-I, A-II, C-II, and C-III concentrations among the study groups. Plasma triglyceride concentrations in the two transplant groups were similar (114 +/- 20 versus 142 +/- 18 mg/dL) and were slightly more than those in the normal subjects (80 +/- 7 mg/dL). CONCLUSION:Despite peripheral hyperinsulinemia, pancreas transplantation can result in normal or near-normal lipid and lipoprotein concentrations. Thus, systemic delivery of insulin does not invariably produce an atherogenic lipid profile.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Katz HH,Nguyen TT,Velosa JA,Robertson RP,Rizza RAdoi
10.1016/s0025-6196(12)61061-1subject
Has Abstractpub_date
1994-03-01 00:00:00pages
231-6issue
3eissn
0025-6196issn
1942-5546pii
S0025-6196(12)61061-1journal_volume
69pub_type
杂志文章abstract:OBJECTIVE:To report a case of eosinophilic myocarditis with remarkable initial clinical manifestations and outcome. MATERIAL AND METHODS:A 67-year-old woman with hypertension and a history of asthma and drug hypersensitivity was referred to our institution with a diagnosis of acute myocardial infarction on the basis o...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:
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abstract:OBJECTIVE:To report the long-term follow-up of a matched comparison of radical nephrectomy (RN) and nephron-sparing surgery (NSS) in patients with single unilateral renal cell carcinoma (RCC) and a normal contralateral kidney. PATIENTS AND METHODS:Between August 1966 and March 1999, 1492 and 189 patients with unilater...
journal_title:Mayo Clinic proceedings
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
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journal_title:Mayo Clinic proceedings
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doi:10.1016/s0025-6196(12)62086-2
更新日期:1991-07-01 00:00:00
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journal_title:Mayo Clinic proceedings
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journal_title:Mayo Clinic proceedings
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doi:
更新日期:1982-11-01 00:00:00
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pub_type: 历史文章,杂志文章
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更新日期:2006-08-01 00:00:00
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journal_title:Mayo Clinic proceedings
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更新日期:1987-09-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/76.11.1120
更新日期:2001-11-01 00:00:00
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journal_title:Mayo Clinic proceedings
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doi:
更新日期:1977-11-01 00:00:00
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doi:10.4065/77.6.515
更新日期:2002-06-01 00:00:00
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journal_title:Mayo Clinic proceedings
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更新日期:1983-11-01 00:00:00
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journal_title:Mayo Clinic proceedings
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doi:
更新日期:1977-02-01 00:00:00
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journal_title:Mayo Clinic proceedings
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doi:10.1016/S0025-6196(11)63944-X
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2011.09.005
更新日期:2012-02-01 00:00:00
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doi:10.4065/79.11.1409
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journal_title:Mayo Clinic proceedings
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doi:10.4065/71.9.854
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更新日期:2019-11-01 00:00:00
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更新日期:1996-10-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:
更新日期:1979-12-01 00:00:00
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doi:10.1016/j.mayocp.2012.10.021
更新日期:2013-02-01 00:00:00
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journal_title:Mayo Clinic proceedings
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更新日期:2007-12-01 00:00:00
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更新日期:2015-06-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/S0025-6196(11)60670-8
更新日期:2009-11-01 00:00:00