Basis for the ICRP's age-specific biokinetic model for uranium.

Abstract:

:In an effort motivated largely by the Chernobyl nuclear accident, the International Commission on Radiological Protection (ICRP) is developing age-specific biokinetic models and dose coefficients for environmentally important radionuclides. This paper describes the ICRP's age-specific biokinetic model for uranium. The model is constructed within a physiologically based framework originally developed for application to the alkaline earth elements but sufficiently general to apply to the larger class of bone-volume-seeking elements. Transfer rates for a reference adult are based mainly on: 1. measurements of uranium in blood and excreta of several human subjects who were intravenously injected with uranium; 2. postmortem measurements of uranium in tissues of some of those subjects; 3. postmortem measurements of uranium in tissues of occupationally and non-occupationally exposed subjects; 4. data on baboons, dogs, and smaller laboratory animals exposed to uranium for experimental purposes; and 5. consideration of the physiological processes thought to control retention and translocation of uranium in the body. Transfer rates for the adult are extended to children by application of a set of generic assumptions applied by the ICRP to calcium-like elements. These assumptions were derived mainly from observations of the age-specific biokinetics of the alkaline earth elements and lead in humans and laboratory animals but are consistent with available age-specific biokinetic data on uranium.

journal_name

Health Phys

journal_title

Health physics

authors

Leggett RW

doi

10.1097/00004032-199412000-00002

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

589-610

issue

6

eissn

0017-9078

issn

1538-5159

journal_volume

67

pub_type

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