Abstract:
:Lymphoid lineage recovery and involution after exposure to potentially lethal doses of ionizing radiation have not been well defined, especially the long-term effects in aged survivors and with regard to male/female differences. To examine these questions, male and female C57BL/6 mice were exposed to lethal radiation at 12 wk of age in a model of the Hematopoietic-Acute Radiation Syndrome, and bone marrow, thymus, spleen, and peripheral blood examined up to 24 mo of age for the lymphopoietic delayed effects of acute radiation exposure. Aged mice showed myeloid skewing and incomplete lymphocyte recovery in all lymphoid tissues. Spleen and peripheral blood both exhibited a monophasic recovery pattern, while thymus demonstrated a biphasic pattern. Naïve T cells in blood and spleen and all subsets of thymocytes were decreased in aged irradiated mice compared to age-matched non-irradiated controls. Of interest, irradiated males experienced significantly improved reconstitution of thymocyte subsets and peripheral blood elements compared to females. Bone marrow from aged irradiated survivors was significantly deficient in the primitive lymphoid-primed multipotent progenitors and common lymphoid progenitors, which were only 8-10% of levels in aged-matched non-irradiated controls. Taken together, these analyses define significant age- and sex-related deficiencies at all levels of lymphopoiesis throughout the lifespan of survivors of the Hematopoietic-Acute Radiation Syndrome and may provide a murine model suitable for assessing the efficacy of potential medical countermeasures and therapeutic strategies to alleviate the severe immune suppression that occurs after radiation exposure.
journal_name
Health Physjournal_title
Health physicsauthors
Wu T,Plett PA,Chua HL,Jacobsen M,Sandusky GE,MacVittie TJ,Orschell CMdoi
10.1097/HP.0000000000001352subject
Has Abstractpub_date
2020-11-01 00:00:00pages
647-658issue
5eissn
0017-9078issn
1538-5159pii
00004032-202011000-00009journal_volume
119pub_type
杂志文章相关文献
HEALTH PHYSICS文献大全abstract::This paper provides a review and reanalysis of data relating to gastrointestinal (GI) uptake of uranium in humans. Estimates of GI uptake of uranium in adult humans have been derived from results of three controlled experimental studies involving short-term oral intake of an elevated quantity of uranium in fluids, fro...
journal_title:Health physics
pub_type: 杂志文章,评审
doi:10.1097/00004032-199504000-00005
更新日期:1995-04-01 00:00:00
abstract::In the assessment of risk, several factors affect predictions: selection of reactive agent, selection of tumor incidence data, modeling of dose, scaling across species, adjustment for differences in duration and frequency of exposure, and selection of the most suitable risk extrapolation model. If the endpoints, expos...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198907001-00046
更新日期:1989-01-01 00:00:00
abstract::Neyman-Pearson principles are briefly discussed and 95% confidence intervals of the form [0, ##.##] are presented. Use is made of the fact that the probability of the difference of two random variables, each with a Poisson distribution, can be expressed in terms of modified Bessel functions of integral order and eleme...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199911001-00013
更新日期:1999-11-01 00:00:00
abstract::The monetary value of the averted dose is a key element in the implementation of the optimization principle both in radiation praxis and intervention. The main concept of this principle is to select options so as to maintain exposures at a reasonable level. The feature of this concept is to look for the minimal total ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-200102000-00004
更新日期:2001-02-01 00:00:00
abstract::Diagnostic reference levels (DRLs) for medical x-ray procedures are being implemented currently in the Netherlands. By order of the Dutch Healthcare Inspectorate, a survey has been conducted among 20 Dutch hospitals to investigate the level of implementation of the Dutch DRLs in current radiological practice. It turns...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000227
更新日期:2015-04-01 00:00:00
abstract::The life-time tumor dose-response relationships observed in beagles injected with 226Ra or fed 90Sr at the University of California, Davis, provide a basis for understanding the induction of bone cancer for these bone-seeking radionuclides and for scaling to people. In these studies 385 dogs were exposed to graded dos...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198306001-00002
更新日期:1983-01-01 00:00:00
abstract::The frequency of hypoxanthine-guanine phosphoribosyltransferase (hprt) mutations has been determined in the peripheral T-lymphocytes of 18 workers at the Sellafield nuclear reprocessing installation with cumulative recorded radiation doses of about 500 mSv or more in comparison with a matched control group of 18 worke...
journal_title:Health physics
pub_type: 临床试验,杂志文章
doi:10.1097/00004032-199503000-00011
更新日期:1995-03-01 00:00:00
abstract::Transportable (e.g., "giraffe") air samplers can be used for both short-term "grab-sampling" situations involving a few minutes to several hours, as well as for long-term retrospective air sampling situations that typically last a week. It is the short-term coverage situation which begs the question: "how long a sampl...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0b013e318204aa78
更新日期:2011-08-01 00:00:00
abstract::Reported here are results of a 1982 national survey in France to establish the collective effective dose equivalent associated with the main types of radiological examinations practiced annually in this country (except nuclear medicine, C.T. scans, dental radiology and mass chest screening). This report describes the ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198804000-00002
更新日期:1988-04-01 00:00:00
abstract::A radioactive particulate release experiment to produce a near-field ground deposition representative of small-scale venting from an underground nuclear test was conducted to gather data in support of treaty capability development activities. For this experiment, a CO2-driven "air cannon" was used to inject (140)La, a...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000506
更新日期:2016-05-01 00:00:00
abstract::A group of 219 subjects of Slovak adults from both sexes were studied for potassium body content by measuring the whole body activity of naturally occurring 40K using a whole body counter. The average body potassium value is 1.68 +/- 0.33 g kg(-1) body weight for males and 1.60 +/- 0.30 g kg(-1) for females. For both ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199803000-00007
更新日期:1998-03-01 00:00:00
abstract::The apparent risk of childhood leukemia resulting from paternal pre-conception radiation exposure found among children of the Sellafield (West Cumbria, UK) workforce is compared with the apparent risk in a number of other epidemiological studies. In particular, the extent of the incompatibility of the leukemia pre-con...
journal_title:Health physics
pub_type: 杂志文章,评审
doi:10.1097/00004032-199503000-00001
更新日期:1995-03-01 00:00:00
abstract::The processes of uranium extraction, purification, and manufacture involve the risk of chemical intoxication. Acute uranium poisoning elicits renal failure which in turn may lead to death. Great efforts have been put into the search for a protective agent for acute uranium poisoning. Several chelating agents such as E...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199405000-00005
更新日期:1994-05-01 00:00:00
abstract::With possibilities for radiation terrorism and intensified concerns about nuclear accidents since the recent Fukushima Daiichi event, the potential exposure of large numbers of individuals to radiation that could lead to acute clinical effects has become a major concern. For the medical community to cope with such an ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0b013e3182588d92
更新日期:2012-09-01 00:00:00
abstract::Radionuclide decorporation is the only effective method of reducing radiation dose for persons contaminated accidentally. In this study, dogs that had inhaled a moderately soluble aerosol of 244Cm2O3 were treated with either discrete intravenous injections of the chelating agent diethylenetriaminepentaacetic acid (Zn-...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199204000-00002
更新日期:1992-04-01 00:00:00
abstract::Information on the 240Pu/239Pu isotope ratios in human tissues for people living around the Semipalatinsk Nuclear Test Site (SNTS) was deduced from 9 sets of soft tissues and bones, and 23 other bone samples obtained by autopsy. Plutonium was radiochemically separated and purified, and plutonium isotopes (239Pu and 24...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/01.HP.0000314807.29873.71
更新日期:2008-09-01 00:00:00
abstract::The role of environmental radiation in the etiology of birth defects, stillbirths, and other adverse outcomes of pregnancy was evaluated for 13,329 Navajos born at the Public Health Service/Indian Health Service Hospital in the Shiprock, NM, uranium mining area (1964-1981). More than 320 kinds of defective congenital ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199211000-00005
更新日期:1992-11-01 00:00:00
abstract::The concentration of 220Rn in the exhaled breath of workers currently employed in a Th plant was measured using a double filter system. The results are expressed in terms of the equivalent activity of 224Ra freely emanating 220Rn at the mouth. Measurements performed on 176 subjects, without isolating them from day-to-...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198612000-00004
更新日期:1986-12-01 00:00:00
abstract::The Human Monitoring Laboratory (HML) has had a number of BOMAB phantoms built over the years. Upon characterization, it has been found that the dimensions of the phantoms are always slightly different. This study has looked at the effect of these small variances in dimensions of the phantoms and compared the results ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/01.HP.0000305820.67206.31
更新日期:2008-06-01 00:00:00
abstract::Radiostrontium isotopes (Sr, Sr, and Sr) are major fission by-products in nuclear reactors, in radiological events, and in environmental radioactive contamination. A method to analyze Sr and Sr in water has been developed using gradient elution with dilute hydrochloric acid and cation exchange resin, followed by carbo...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000001020
更新日期:2019-06-01 00:00:00
abstract::Fallout 137Cs levels in soil were measured at 11 diverse sites throughout Montana. Concentrations in near-surface samples ranged from 20-200 mBq g-1 (0.51-5.41 pCi g-1). Most of the 137Cs was in the top 10 cm of soil. Deeper occurrences were attributed to disturbances by animals and to interstitial flow of small sedim...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198912000-00010
更新日期:1989-12-01 00:00:00
abstract::This study was motivated by the efforts to evaluate radiation risk for leukemia incidence in the Techa River cohort, where the main bone marrow dose contributors were Sr (bone-seeking beta emitters). Energy deposition in bone marrow targets was evaluated by simulating radiation particle transport using computational p...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000001127
更新日期:2020-01-01 00:00:00
abstract::Following a large-scale radiation emergency, affected populations will need to be screened soon after for potential contamination (external or internal). Effective management of the available resources can help maximize the screening throughputs. This paper reports the modeling results for screening throughputs in a p...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000114
更新日期:2014-05-01 00:00:00
abstract::Nuclear weapons testing was conducted in the atmosphere at numerous sites worldwide between 1946 and 1980, which resulted in exposures to local populations as a consequence of fallout of radioactive debris. The nuclear tests were conducted by five nations (United States, Soviet Union, United Kingdom, France, and China...
journal_title:Health physics
pub_type: 杂志文章,评审
doi:10.1097/00004032-200205000-00016
更新日期:2002-05-01 00:00:00
abstract::On 30 September 1999, three workers were severely exposed to neutrons and gamma rays in a criticality accident that occurred at a uranium conversion facility in Tokai-mura, Ibaraki Prefecture, Japan. Radiochemical analyses of 32P and 45Ca induced by neutrons in bone matrix were carried out after the deaths of two of t...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-200207000-00002
更新日期:2002-07-01 00:00:00
abstract::This commentary evaluates two sets of guidelines for human exposure to radiofrequency (RF) energy, focusing on the frequency range above the "transition" frequency at 3-10 GHz where the guidelines change their basic restrictions from specific absorption rate to incident power density, through the end of the RF band at...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000671
更新日期:2017-07-01 00:00:00
abstract::The predecessor organizations of the National Council on Radiation Protection and Measurements (NCRP) were established in 1929 (the U.S. Advisory Committee on X-Ray and Radium Protection) and in 1946 (the National Committee on Radiation Protection and Measurements). In 1964, the NCRP was formally chartered by the U.S....
journal_title:Health physics
pub_type: 历史文章,杂志文章,评审
doi:10.1097/00004032-200409000-00014
更新日期:2004-09-01 00:00:00
abstract::This review/commentary addresses recent thermal and electromagnetic modeling studies that use image-based anthropomorphic human models to establish the local absorption of radiofrequency energy and the resulting increase in temperature in the body. The frequency range of present interest is from 100 MHz through the tr...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000854
更新日期:2018-08-01 00:00:00
abstract::Dissolution characteristics of mixed-oxide nuclear fuels are important considerations for prediction of biological behavior of inhaled particles. Four representative industrial mixed-oxide powders were obtained from fuel fabrication enclosures. Studies of the dissolution of Pu, Am and U from aerosol particles of these...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198312000-00001
更新日期:1983-12-01 00:00:00
abstract::It is pointed out that induction of lung cancer by exposure to Rn daughters, applied at high doses to miners and at low doses to exposures in homes, provides a very stringent and sensitive test of the linear, no-threshold dose-response relationship for high-LET radiation, because this relationship predicts that a subs...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198705000-00015
更新日期:1987-05-01 00:00:00