Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer.

abstract：:Searches of ribosomal RNA sequences for compensatory base changes preserving Watson-Crick base pairing have led to detailed models of the conserved secondary structures of these RNAs. In principle, tertiary interactions can also be detected by searches for phylogenetically covariant bases. Within a highly conserved re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ryan PC,Draper DE

更新日期：1991-07-15 00:00:00

abstract：:Human platelets stimulated by epinephrine undergo enhanced turnover of phosphatidylinositol 4,5-bisphosphate, accumulate inositol trisphosphate, diacylglycerol, and phosphatidic acid, and phosphorylate a 47-kDa protein. All of these phenomena indicate stimulation of phospholipase C. These responses are blocked complet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banga HS,Simons ER,Brass LF,Rittenhouse SE

更新日期：1986-12-01 00:00:00

abstract：:Marriage in many traditional societies often concerns the institutionalized exchange of reproductive partners among groups of kin. Such exchanges most often involve cross-cousins-marriage with the child of a parent's opposite-sex sibling-but it is unclear who benefits from these exchanges. Here we analyze the fitness ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chagnon NA,Lynch RF,Shenk MK,Hames R,Flinn MV

更新日期：2017-03-28 00:00:00

abstract：:The management of harmful species, including invasive species, pests, parasites, and diseases, is a major global challenge. Harmful species cause severe damage to ecosystems, biodiversity, agriculture, and human health. In particular, managing harmful species often requires cooperation among multiple agents, such as l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lampert A

更新日期：2020-05-12 00:00:00

abstract：:Although heparin and low-molecular-weight heparins (LMWH) have been widely used clinically as anticoagulants, their broader use has been limited by the lack of noninvasive delivery methods for this class of molecules. In this study, we demonstrate an efficient, rapid, and reproducible delivery system for heparin throu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qi Y,Zhao G,Liu D,Shriver Z,Sundaram M,Sengupta S,Venkataraman G,Langer R,Sasisekharan R

更新日期：2004-06-29 00:00:00

abstract：:Hereditary hemochromatosis (HH) is a disorder of iron metabolism caused by common mutations in the gene HFE. The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake. However, in vivo, HFE is strongly expressed by liver macropha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drakesmith H,Sweetland E,Schimanski L,Edwards J,Cowley D,Ashraf M,Bastin J,Townsend AR

更新日期：2002-11-26 00:00:00

abstract：:Kruppel-like factor 4 (KLF4) is involved in self-renewal of embryonic stem cells and reprogramming of somatic cells to pluripotency. However, its role in lineage-committed stem cells remains largely unknown. Here, we show that KLF4 is expressed in neural stem cells (NSCs) and is down-regulated during neuronal differen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin S,Liu M,Niu W,Zhang CL

更新日期：2011-12-27 00:00:00

abstract：:Animals are typically colonized by diverse bacterial symbionts, many of which are commensal and, in numerous cases, even essential for their host's proper development and growth. In exchange, the host must supply a sufficient array and quantity of nutrients to support the proliferation and persistence of its microbial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graf J,Ruby EG

更新日期：1998-02-17 00:00:00

abstract：:Burkitt's lymphomas, linked by previous studies with the DNA-containing Epstein-Barr virus, contain an RNA related in sequence to that of Rauscher leukemia virus. The present study establishes that the viral-related RNA found in Burkitt's tumors is a 70S component encapsulated with RNA-instructed DNA polymerase in a p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kufe D,Magrath IT,Ziegler JL,Spiegelman S

更新日期：1973-03-01 00:00:00

abstract：:Phosphorylation of the regulatory (R) domain initiates cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel activity. To discover how the function of this domain is determined by its structure, we produced an R domain protein (R8) that spanned residues 708-831 of CFTR. Phosphorylated, but not unpho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ostedgaard LS,Baldursson O,Vermeer DW,Welsh MJ,Robertson AD

更新日期：2000-05-09 00:00:00

abstract：:Pentameric ligand-gated ion channels (pLGICs), which mediate chemo-electric signal transduction in animals, have been recently found in bacteria. Despite clear sequence and 3D structure homology, the phylogenetic distance between prokaryotic and eukaryotic homologs suggests significant structural divergences, especial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duret G,Van Renterghem C,Weng Y,Prevost M,Moraga-Cid G,Huon C,Sonner JM,Corringer PJ

更新日期：2011-07-19 00:00:00

abstract：:Keratins 14 and 5 are the structural hallmarks of the basal keratinocytes of the epidermis and outer root sheath (ORS) of the hair follicle. Their genes are controlled in a tissue-specific manner and thus serve as useful tools to elucidate the regulatory mechanisms involved in keratinocyte-specific transcription. Prev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sinha S,Fuchs E

更新日期：2001-02-27 00:00:00

abstract：:Myosin V is an unconventional myosin proposed to be processive on actin filaments, analogous to kinesin on a microtubule [Mehta, A. D., et al. (1999) Nature (London) 400, 590-593]. To ascertain the unique properties of myosin V that permit processivity, we undertook a detailed kinetic analysis of the myosin V motor. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De La Cruz EM,Wells AL,Rosenfeld SS,Ostap EM,Sweeney HL

更新日期：1999-11-23 00:00:00

abstract：:Phage phi 29 terminal protein, p3, essentially pure, was isolated in a denatured form from viral particles, and anti-p3 antiserum was obtained. A radioimmunoassay to detect and quantitate protein p3 was developed. By using this assay, native protein p3 was highly purified from Escherichia coli cells harboring a gene 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prieto I,Lázaro JM,García JA,Hermoso JM,Salas M

更新日期：1984-03-01 00:00:00

abstract：:Along the evolutionary path from single cells to multicellular organisms with a central nervous system are species of intermediate complexity that move in ways suggesting high-level coordination, yet have none. Instead, organisms of this type possess many autonomous cells endowed with programs that have evolved to ach...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drescher K,Goldstein RE,Tuval I

更新日期：2010-06-22 00:00:00

abstract：:The amount of information that can be stored in working memory is limited but may be improved with practice. The basis of improved efficiency at the level of neural activity is unknown. To investigate this question, we trained monkeys to perform a working memory task that required memory for multiple stimuli. Performa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tang H,Qi XL,Riley MR,Constantinidis C

更新日期：2019-04-02 00:00:00

abstract：:The semidwarf phenotype has been extensively selected during modern crop breeding as an agronomically important trait. Introduction of the semidwarf gene, semi-dwarf1 (sd1), which encodes a gibberellin biosynthesis enzyme, made significant contributions to the "green revolution" in rice (Oryza sativa L.). Here we repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asano K,Yamasaki M,Takuno S,Miura K,Katagiri S,Ito T,Doi K,Wu J,Ebana K,Matsumoto T,Innan H,Kitano H,Ashikari M,Matsuoka M

更新日期：2011-07-05 00:00:00

abstract：:We have examined whether dissociation of the histone octamer is required for elongation of RNA transcripts through arrays of nucleosome cores in vitro. Control or dimethyl suberimidate-crosslinked histone octamers were reconstituted onto supercoiled, closed circular pT207-18 DNA, which contains tandemly repeated 207-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Neill TE,Smith JG,Bradbury EM

更新日期：1993-07-01 00:00:00

abstract：:Osmotically shocked Escherichia coli and membrane vesicle ghosts from E. coli cells have lost the ability to accumulate potassium by active transport. The addition of valinomycin to the membrane ghosts restores the capacity to accumulate radioactive (42)K and (86)Rb by a temperature- and energy-dependent process. Memb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhattacharyya P,Epstein W,Silver S

更新日期：1971-07-01 00:00:00

abstract：:BCL6 encodes a transcriptional repressor that is essential for the germinal center (GC) reaction and important in lymphomagenesis. Although its promoter has been well studied, little is known concerning its possible regulation by more distal elements. To gain such information, we mapped critical histone modifications ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramachandrareddy H,Bouska A,Shen Y,Ji M,Rizzino A,Chan WC,McKeithan TW

更新日期：2010-06-29 00:00:00

abstract：:The mitochondria are the major source of chronic oxidative stress, which has been implicated in the aging process. Along with other cellular changes, aged cells accumulate mutations in both their nuclear and mitochondrial genomes, and they contain increased amounts of oxidatively damaged mutagenic bases such as 7,8-di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szczesny B,Hazra TK,Papaconstantinou J,Mitra S,Boldogh I

更新日期：2003-09-16 00:00:00

abstract：:Natural ecosystems contain many individuals and species interacting with each other and with their abiotic environment. Such systems can be expected to exhibit complex dynamics in which small perturbations can be amplified to cause large changes. Here, we document the reorganization of an arid ecosystem that has occur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown JH,Valone TJ,Curtin CG

更新日期：1997-09-02 00:00:00

abstract：:We present evidence that pressures for early childcare may have been one of the driving factors of human evolution. We show through an evolutionary model that runaway selection for high intelligence may occur when (i) altricial neonates require intelligent parents, (ii) intelligent parents must have large brains, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piantadosi ST,Kidd C

更新日期：2016-06-21 00:00:00

abstract：:The epidermal growth factor receptor gene has been found to be amplified and rearranged in human glioblastomas in vivo. Here we present the sequence across a splice junction of aberrant epidermal growth factor receptor transcripts derived from corresponding and uniquely rearranged genes that are coamplified and coexpr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugawa N,Ekstrand AJ,James CD,Collins VP

更新日期：1990-11-01 00:00:00

abstract：:The actin cytoskeleton is a critical regulator of cytoplasmic architecture and mechanics, essential in a myriad of physiological processes. Here we demonstrate a liquid phase of actin filaments in the presence of the physiological cross-linker, filamin. Filamin condenses short actin filaments into spindle-shaped dropl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weirich KL,Banerjee S,Dasbiswas K,Witten TA,Vaikuntanathan S,Gardel ML

更新日期：2017-02-28 00:00:00

abstract：:Type beta transforming growth factor (TGF-beta) activity was found in conditioned medium harvested from fetal rat and neonatal mouse calvariae by using the anchorage-independent growth of normal rat kidney fibroblasts as an indicator system. Calvariae incubated with parathyroid hormone, 1,25-dihydroxyvitamin D3, and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pfeilschifter J,Mundy GR

更新日期：1987-04-01 00:00:00

abstract：:The heroin analogue 1-methyl-4-phenylpyridinium, MPP(+), both in vitro and in vivo, produces death of dopaminergic substantia nigral cells by inhibiting the mitochondrial NADH dehydrogenase multienzyme complex, producing a syndrome indistinguishable from Parkinson's disease. Similarly, a fragment of amyloid protein, A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kashiwaya Y,Takeshima T,Mori N,Nakashima K,Clarke K,Veech RL

更新日期：2000-05-09 00:00:00

abstract：:We have measured the angle-resolved transverse resistivity (ARTR), a sensitive indicator of electronic anisotropy, in high-quality thin films of the unconventional superconductor Sr2RuO4 grown on various substrates. The ARTR signal, heralding the electronic nematicity or a large nematic susceptibility, is present and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Nair HP,Bollinger AT,He X,Robinson I,Schreiber NJ,Shen KM,Schlom DG,Božović I

更新日期：2020-05-19 00:00:00

abstract：:The nuclear lamina is a network of structural filaments, the A and B type lamins, located at the nuclear envelope and throughout the nucleus. Lamin filaments provide the nucleus with mechanical stability and support many basic activities, including gene regulation. Mutations in LMNA, the gene encoding A type lamins, c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dahl KN,Scaffidi P,Islam MF,Yodh AG,Wilson KL,Misteli T

更新日期：2006-07-05 00:00:00

abstract：:Whole-genome duplication (WGD) is believed to be a significant source of major evolutionary innovation. Redundant genes resulting from WGD are thought to be lost or acquire new functions. However, the rates of gene loss and thus temporal process of genome reshaping after WGD remain unclear. The WGD shared by all teleo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue J,Sato Y,Sinclair R,Tsukamoto K,Nishida M

更新日期：2015-12-01 00:00:00