Abstract:
:The relation between TaqI restriction fragment length polymorphisms (RFLPs) of the cholesteryl ester transfer protein (CETP) gene and plasma lipid and lipoprotein phenotypes was investigated in a sample of Italian and Greek migrants of both sexes, age 40-69 years. Italians display significantly higher mean triglyceride and lower mean high-density lipoprotein (HDL) cholesterol levels than Greeks. Greek females have significantly higher HDL cholesterol than Greek males, and Italian females have significantly higher low-density lipoprotein (LDL), HDL, and total cholesterol than Italian males. The differences in RFLP allele frequencies between the two ethnic groups and sexes are insignificant. Multivariate analyses show that in the Greek sample the TaqI B RFLP of the CETP gene has a highly significant effect on HDL cholesterol levels regardless of sex and that the TaqI A polymorphism has a significant effect on HDL levels in females but modulates LDL cholesterol concentrations in males. Among Italians, with the sexes considered separately or combined, no such effects of the CETP TaqI polymorphisms are detected. Kruskal-Wallis tests detected associations between the TaqI B polymorphism in all Greek samples but not in the Italian samples. Genotype CETP*B2 exhibits significantly higher HDL cholesterol concentrations than either of the other two TaqI B genotypes, but there is no evidence of a dosage effect of the *B2 allele. These data suggest that associations between the CETP gene and lipid phenotypes can be population specific. Further, they suggest that such associations are mediated in some way by gender.
journal_name
Hum Bioljournal_title
Human biologyauthors
Mitchell RJ,Earl L,Williams J,Bisucci T,Gasiamis Hsubject
Has Abstractpub_date
1994-02-01 00:00:00pages
13-25issue
1eissn
0018-7143issn
1534-6617journal_volume
66pub_type
杂志文章相关文献
HUMAN BIOLOGY文献大全abstract::Previous studies have sought to associate the Pro12Ala variant of the peroxisome proliferator-activated receptor gamma2 (PPARG2) gene with type 2 diabetes, insulin resistance, and obesity, with controversial results. We have determined the Pro12Ala variant frequency in 370 nondiabetic Mexican Mestizo subjects and in f...
journal_title:Human biology
pub_type: 杂志文章,多中心研究
doi:10.1353/hub.2007.0022
更新日期:2007-02-01 00:00:00
abstract::A recent workshop entitled "The Family Name as Socio-Cultural Feature and Genetic Metaphor: From Concepts to Methods" was held in Paris in December 2010, sponsored by the French National Centre for Scientific Research (CNRS) and by the journal Human Biology. This workshop was intended to foster a debate on questions r...
journal_title:Human biology
pub_type: 杂志文章
doi:10.3378/027.084.0205
更新日期:2012-04-01 00:00:00
abstract::The 657del5 mutation of the NBS1 gene has been demonstrated in most patients with Nijmegen breakage syndrome (NBS). We identified four Turkish families in which probands were diagnosed as having NBS and found to be homozygous for the 657del5 mutation. The 657del5 allele in the four Turkish families had a single origin...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2005.0056
更新日期:2005-06-01 00:00:00
abstract::The method of isonymy, developed by Crow and Mange for estimating inbreeding from surname frequencies, requires an assumption that has not been appreciated: It is necessary to assume that all males in some ancestral generation, the founding stock, had unique surnames. Because this assumption is seldom justified in rea...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract::To what extent can ethnic factors contribute to the prevalence of type 2 diabetes and impaired glucose tolerance (IGT) in an urban Brazilian population? Conversely, how can environmental factors such as diet change these prevalences in a given ethnic group, in this case Brazilian Indians? To answer these questions est...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract::We evaluate the blood pressure profile in relation to selected biological, behavioral, and socioeconomic factors among the Lepchas, a tribal population of Asian origin inhabiting the Dzongu area of northern Sikkim. The results show that mean systolic and diastolic blood pressures of Lepcha adults (aged 19 years and ol...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
abstract::The radical improvement in living conditions experienced in Italy during the last century caused a reduction in male extra-mortality during the prereproductive years. As a consequence, a progressive increase in the sex ratio at the beginning of the reproductive age (15-19 years) occurred, so that in recent times the s...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2001.0014
更新日期:2001-02-01 00:00:00
abstract::HLA-DQB1*0302 allele frequency is increased in liver graft recipients with acute rejection. We investigated polymorphism in the upstream regulatory regions (URRs) of the DQB1 gene to determine whether polymorphism in the DQB1 promoter region influences liver graft acceptance. A combination of typing protocols based on...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2001.0088
更新日期:2001-12-01 00:00:00
abstract::A mismatch distribution is a tabulation of the number of pairwise differences among all DNA sequences in a sample. In a population that has been stationary for a long time these distributions from nonrecombinant DNA sequences become ragged and erratic, whereas a population that has been growing generates mismatch dist...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::A Buryat population consisting of seven tribal groups in eastern Mongolia has been screened to determine the frequency distribution of different apolipoprotein E and H alleles (APOE and APOH, genes) coding for common isoforms and their association with quantitative plasma lipid levels. Allele frequencies at the APOE l...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2002.0058
更新日期:2002-10-01 00:00:00
abstract::Several studies have shown evidence of an association between the *4 allele of apolipoprotein E (APOE) and coronary heart disease (CHD) in different populations. We determined the APOE genotype and total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDLC) values in 189 patients with a...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2005.0036
更新日期:2005-04-01 00:00:00
abstract::We used 15 short tandem repeat (STR) loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, VWA, TPOX, D18S51, D5S818, and FGA) to genetically characterize 361 individuals from 11 indigenous populations (Amuzgo, Chinanteco, Chontal, Huave, Mazateco, Mixe, Mixteco, Triqui, Zapoteco de...
journal_title:Human biology
pub_type: 杂志文章
doi:10.3378/027.082.0405
更新日期:2010-08-01 00:00:00
abstract::Hematocrit values are normally higher in natives living at high altitude than in natives living at sea level. Here, we have determined the hematocrit levels in relation to adrenal androgens in children living at altitudes of 150 m and 3400 m above sea level. The data demonstrate no association between serum adrenal an...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::In one of the truly classic works in anthropological genetics, Frank Livingstone established the interrelationships between agriculture, mosquito ecology, malaria, and, consequently, the frequencies of sickle cell hemoglobin in West Africa. A major inference from Livingstone's study was the recency of malaria as a sel...
journal_title:Human biology
pub_type: 历史文章,杂志文章,评审
doi:10.1353/hub.2003.0053
更新日期:2003-08-01 00:00:00
abstract::I describe the developmental, metric, morphologic, and pathologic features of deciduous dentition in a terminal Late Archaic (c. 3000 B.P.) Native American population in Ohio. Development of deciduous dentition in this Late Archaic population is stable with little sequence variation. The pattern of development (ldc, l...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::Restriction fragment length polymorphisms are good anthropological markers for discriminating geographically distinct populations at both the allele and the haplotype level. Two communities of African ancestry and ladinos, mestizos, and mulattoes living in the Esmeraldas province in northwestern Ecuador were analyzed ...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2005.0031
更新日期:2005-02-01 00:00:00
abstract::Low-molecular-weight acid phosphatase (ACP1) is a polymorphic protein-tyrosine phosphatase present in all human tissues, including adipocytes. A positive association between the low-activity ACP1*A/*A genotype and extreme body mass index has previously been shown by us in obese subjects from the population of Rome. We...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1997-08-01 00:00:00
abstract::Most of the inhabitants of South Tyrol in the eastern Italian Alps can be considered isolated populations because of their physical separation by mountain barriers and their sociocultural heritage. We analyzed the genetic structure of South Tyrolean populations using three types of genetic markers: Y-chromosome, mitoc...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2006.0057
更新日期:2006-08-01 00:00:00
abstract::This address is a tribute to a pioneer of population genetics, including human population genetics. The unique methodology employed by Sewall Wright in many genetic problems is the method of path coefficients. This essay traces the historical landmarks in the development of the path method and then shows how some of t...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:
更新日期:1991-02-01 00:00:00
abstract::Human populations have a complex history of introgression and of changing population size. Human genetic variation has been affected by both these processes, so inference of past population size depends upon the pattern of gene flow and introgression among past populations. One remarkable aspect of human population hi...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:10.13110/humanbiology.89.1.04
更新日期:2017-01-01 00:00:00
abstract::We describe the gene frequency distributions for 29 different blood group, serum, and erythrocytic proteins for three Mennonite communities from Kansas and Nebraska and compare their gene frequencies with those of Amish, Hutterite, and Mennonite populations using the topological method of Harpending and Jenkins (1973)...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract::The Sicilian population has a complex history of colonization and invasions that have influenced the genetic composition of the nine provinces of the island. Because surnames are patrilineally inherited, they simulate a Y-chromosome nonrecombinant genetic locus. We used surname data and a specific sampling strategy to...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2005.0015
更新日期:2004-12-01 00:00:00
abstract::There has been a lack of agreement on the variation in and the correlates of menstrual cycle length in the literature. A total of 2566 women from rural and urban areas in one district of Tamil Nadu in southern India were studied prospectively to identify correlates of menstrual cycle length. Rural women had higher odd...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::Mitochondrial DNA haplotype studies have been useful in unraveling the origins of Native Americans. Such studies are based on restriction site and intergenic deletion/insertion polymorphisms, which define four main haplotype groups common to Asian and American populations. Several studies have characterized these line...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2002.0022
更新日期:2002-04-01 00:00:00
abstract::Seventy individuals from two African and four black Brazilian populations were studied for the first hypervariable segment of mtDNA. To delineate a more complete phylogeographic scenario of the African mtDNA haplogroups in Brazil and to provide additional information on the nature of the Atlantic slave trade, we analy...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2006.0028
更新日期:2006-02-01 00:00:00
abstract::Mutations in the GJB2 gene are a major cause of congenital deafness. One specific mutation, the 35delG mutation, has accounted for most of the GJB2 mutations detected in European populations and is one of the most frequent disease mutations identified so far. We evaluated the frequency of the 35delG mutation in DNA sa...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2004.0035
更新日期:2004-04-01 00:00:00
abstract::The main goal of the present study is to elucidate the extent to which primary characteristics of bone aging are determined by major gene effects. We report the results of a complex segregation analysis of bone mineral density (BMD) and osseographic score (OS) carried out on an array of pedigrees from rural Turkmenia....
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract::Given that the evidence of a substantial genetic contribution to cognitive ability is now convincing, the next challenge is to locate and identify the genes involved. It is likely that there are several genes, each of only small effect. Detection of such so-called quantitative trait loci contributing to polygenic trai...
journal_title:Human biology
pub_type: 杂志文章,评审
doi:
更新日期:1998-04-01 00:00:00
abstract::We analyze the possible effect of gene flow on the genetic structure of present-day Mexicans. For this purpose we reviewed previous admixture estimates for various Indian and Mestizo groups. Several facts seem clear: (1) There are no pure Indian groups in Mexico, because all Indian groups show variable degrees of admi...
journal_title:Human biology
pub_type: 杂志文章,多中心研究
doi:
更新日期:1996-06-01 00:00:00
abstract::Details of the population pyramid of living Herero and Mbanderu of Botswana suggest that infant and childhood mortality of males has been substantially greater than that of females. Direct tests from reproductive histories show that the hazard ratio is approximately 3 to 1 in favor of female survival in infancy and 2 ...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00