Simulating hemoglobin history.

Abstract:

:In one of the truly classic works in anthropological genetics, Frank Livingstone established the interrelationships between agriculture, mosquito ecology, malaria, and, consequently, the frequencies of sickle cell hemoglobin in West Africa. A major inference from Livingstone's study was the recency of malaria as a selective agent in human populations, only becoming significant after the adoption of agriculture in the last few thousand years. Clines of the abnormal hemoglobin alleles might therefore represent continuing waves of advance of adaptive alleles. In order to model the complex interaction of several hemoglobin alleles, selection, and gene flow spreading adaptive mutants, Livingstone turned to computer simulation. Numerous insights concerning the competitive increase of different alleles (hemoglobins S, C, and E and thalassemia), the rate of allele spread under different migration scenarios, including the potential importance of long-range migration, came out of these studies. These experiments also stimulated others to search for mechanisms that might increase the diffusion rate of hemoglobin variants, including kin-structured migration and epidemic disease selection. Recent molecular studies have substantiated major aspects of Livingstone's work (including the recent origin of falciparum malaria) and posed challenges to some of his assumptions (such as the number of mutations to hemoglobins S and E). But whatever the fate of his specific hypotheses, his emphasis on the interaction of genetics, ecology, and culture stands as a model for the anthropological approach to the understanding of human variation and evolution.

journal_name

Hum Biol

journal_title

Human biology

authors

Fix AG

doi

10.1353/hub.2003.0053

keywords:

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

607-18

issue

4

eissn

0018-7143

issn

1534-6617

journal_volume

75

pub_type

历史文章,杂志文章,评审
  • Did food increase fertility? Evaluation of !Kung and Herero history.

    abstract::Low fertility among nomadic !Kung foragers of the northern Kalahari Desert of Botswana has been hypothesized to be an adaptation to scarcity of food. However, a comparison of !Kung fertility before and after a transition to a more sedentary lifestyle indicates that more food did not increase fertility. An examination ...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:

    authors: Pennington R

    更新日期:1992-08-01 00:00:00

  • Single nucleotide polymorphism analysis of the nucleotide excision repair genes XPC, XPA, and XPG in the Indian population.

    abstract::We have analyzed single nucleotide polymorphisms (SNPs) in the XPC, XPA, and XPG genes of the nucleotide excision repair (NER) pathway in the Indian population. In the XPC gene we observed nine polymorphisms in the coding region, four polymorphisms in the intronic region, and two polymorphisms in the 5' untranslated r...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:10.1353/hub.2008.0005

    authors: Gowda S,Kumaran M,Suma BS,Rao MR

    更新日期:2007-10-01 00:00:00

  • Different patterns of variation at the X- and Y-chromosome-linked microsatellite loci DXYS156X and DXYS156Y in human populations.

    abstract::We compared the global pattern of variation at two homologous microsatellites mapping to the long arm of the X chromosome (DXYS156X) and to the short arm of the Y chromosome (DXYS156Y) in humans. A single pair of oligonucleotide primers amplifies these two nonallelic loci, each of which contains polymorphism in the nu...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:

    authors: Karafet T,de Knijff P,Wood E,Ragland J,Clark A,Hammer MF

    更新日期:1998-12-01 00:00:00

  • RFLPs of the APOB gene: comparative study between Greeks and southern Italian peoples.

    abstract::Restriction fragment length polymorphisms (RFLPs) at codons 2488 (XbaI), 3611 (MspI), and 4154 (EcoRI) of the apolipoprotein B gene were investigated in sample groups from Athens (Greece) and Calabria (southern Italy) to verify whether the distribution of the APOB gene variants in Calabria, where Greek colonization oc...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:

    authors: De Benedictis G,Leone O,Falcone E,Rose G,Brancati C,Carotenuto L

    更新日期:1993-06-01 00:00:00

  • Genetic polymorphism study at four minisatellite loci (D1S80, D17S5, D19S20, and APOB) among five Indian population groups.

    abstract::The present study reports the genetic variation observed among five anthropologically distinct population groups of India, using four highly polymorphic minisatellite loci (D1S80, D17S5, D19S20, and APOB 3' VNTR) in order to examine the effect of geographical and linguistic affiliations on the genetic affinities among...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:10.1353/hub.2002.0028

    authors: Das B,Ghosh A,Chauhan PS,Seshadri M

    更新日期:2002-06-01 00:00:00

  • CYP2A6 polymorphism reveals differences in Japan and the existence of a specific variant in Ovambo and Turk populations.

    abstract::CYP2A6 is a polymorphic enzyme, and CYP2A6 genotype has been shown to be associated with smoking habits and lung cancer. We investigated CYP2A6 polymorphism in Japanese from four different geographic areas of Japan and in the Ovambo and Turk populations. Using two polymerase chain reaction restriction fragment length ...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:10.1353/hub.2006.0037

    authors: Takeshita H,Hieda Y,Fujihara J,Xue Y,Nakagami N,Takayama K,Imamura S,Kataoka K

    更新日期:2006-04-01 00:00:00

  • Reconstructing population history using JC virus: Amerinds, Spanish, and Africans in the ancestry of modern Puerto Ricans.

    abstract::The roots of the Hispanic populations of the Caribbean Islands and Central and South America go back to three continents of the Old World. In Puerto Rico major genetic contributions have come from (1) Asians in the form of the aboriginal Taino population, an Arawak tribe, present when Columbus arrived on the Island, (...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:10.1353/hub.2001.0032

    authors: Fernandez-Cobo M,Jobes DV,Yanagihara R,Nerurkar VR,Yamamura Y,Ryschkewitsch CF,Stoner GL

    更新日期:2001-06-01 00:00:00

  • Restriction fragment length polymorphisms of type I collagen locus 2 (COL1A2) in two communities of African ancestry and other mixed populations of northwestern Ecuador.

    abstract::Restriction fragment length polymorphisms are good anthropological markers for discriminating geographically distinct populations at both the allele and the haplotype level. Two communities of African ancestry and ladinos, mestizos, and mulattoes living in the Esmeraldas province in northwestern Ecuador were analyzed ...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:10.1353/hub.2005.0031

    authors: Rickards O,Martínez-Labarga C,Trucchi E,Renzi F,Casalotti R,Babalini C,Biondi G,Pepe G,De Stefano G

    更新日期:2005-02-01 00:00:00

  • Molecular basis of ESD*5 and ESD*7 and haplotype analysis with new polymorphisms in introns.

    abstract::The two polymorphic alleles of esterase D (ESD), ESD*5 and ESD*7, are specific to Europeans and Asians, respectively. In this study the molecular basis was characterized: ESD*5, arising from ESD*1, has a G to A transition, resulting in Gly257(GGT) --> Asp(GAT); and ESD*7, originating from ESD*2, has an A to G transiti...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:10.1353/hub.2004.0051

    authors: Yuasa I,Umetsu K,Tsuchida S,Irizawa Y,Henke L,Henke J

    更新日期:2004-06-01 00:00:00

  • Fertility differentials within a subdivided population: a controlled comparison of four Sells Papago isolates.

    abstract::4 ethnically, cultural-historically and linguistically distinct subsets of the Sells Reservation Papago population of southern Arizona are identified using ethnographic and demographic data. Breeding patterns of these 4 isolates are described and compared with fertility and mortality parameters. Isolates which exper...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:

    authors: Smith DG

    更新日期:1980-05-01 00:00:00

  • Oral contraceptives and fat patterning in young adult women.

    abstract::90 nulliparous white female college students, selected from 2 undergraduate introductory courses at Kansas University, participated in a cross-sectional study designed to compare the fat distribution of oral contraceptive (OC) users to that of nonusers matched for height and weight. The subjects ranged in age from 18...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:

    authors: Litchfield RE,Grunewald KK

    更新日期:1988-10-01 00:00:00

  • Origins of Aleuts and the genetic structure of populations of the archipelago: molecular and archaeological perspectives.

    abstract::We summarize the results of a field and laboratory research program (1999-2006) in the Aleutian Islands on the origins of the inhabitants of the archipelago and the genetic structure of these populations. The Aleuts show closest genetic affinity to the contemporary Siberian Eskimos and Chukchi of Chukotka and differ s...

    journal_title:Human biology

    pub_type: 历史文章,杂志文章

    doi:10.3378/027.082.0511

    authors: Crawford MH,Rubicz RC,Zlojutro M

    更新日期:2010-12-01 00:00:00

  • How the Atacama Skeleton Might Advance Discussion of Responsible Conduct of Research Responsibilities.

    abstract::Controversies resulting from genetic testing on skeletal remains of disputed stewardship raise important questions about obligations inherent on genetic researchers to assure ethical chain of custody. In this article, we analyze and evaluate several proposed positions on whether such research should be published. Foll...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:10.13110/humanbiology.91.1.01

    authors: May T,Nakano-Okuno M

    更新日期:2019-02-17 00:00:00

  • Population substructure and patterns of quantitative variation among the Gollas of southern Andhra Pradesh, India.

    abstract::Population substructure and biological differentiation was studied among the Golla, a pastoral caste living in the southern areas of Andhra Pradesh (AP) in India, using 11 anthropometric measurements and 20 quantitative dermatoglyphic variables. The data were collected from a sample of 334 adult males drawn from 30 vi...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:10.1353/hub.2001.0026

    authors: Reddy BM,Pfeffer A,Crawford MH,Langstieh BT

    更新日期:2001-04-01 00:00:00

  • Digital dermatoglyphic patterns of Eskimo and Amerindian populations: relationships between geographic, dermatoglyphic, genetic, and linguistic distances.

    abstract::Dermatoglyphic traits have been used to assess population affinities and structure. Here, we describe the digital patterns of four Eskimo populations from Alaska: two Yupik-speaking villages from St. Lawrence Island and two Inupik groups presently residing on mainland Alaska. For a broader evolutionary perspective, th...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:

    authors: Crawford MH,Duggirala R

    更新日期:1992-10-01 00:00:00

  • Ethnic differences in the distribution of interleukin-6 polymorphisms among three Brazilian ethnic groups.

    abstract::Polymorphisms in the interleukin-6 promoter region have been associated with diseases. In this study we investigated the -634G/C and -174G/C IL-6 promoter polymorphisms in three Brazilian ethnic groups. We verified that the allele frequencies of the two polymorphisms and haplotype frequencies varied significantly betw...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:10.1353/hub.2005.0061

    authors: Gadelha SR,Alcantara LC,Costa GC,Rios DL,Galvão-Castro B

    更新日期:2005-08-01 00:00:00

  • Frequency of the 35delG mutation in the GJB2 gene in samples of European, Asian, and African Brazilians.

    abstract::Mutations in the GJB2 gene are a major cause of congenital deafness. One specific mutation, the 35delG mutation, has accounted for most of the GJB2 mutations detected in European populations and is one of the most frequent disease mutations identified so far. We evaluated the frequency of the 35delG mutation in DNA sa...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:10.1353/hub.2004.0035

    authors: Oliveira CA,Alexandrino F,Abe-Sandes K,Silva WA Jr,Maciel-Guerra AT,Magna LA,Sartorato EL

    更新日期:2004-04-01 00:00:00

  • Prevalence of genetic versus environmental factors in human female temporal organization: preliminary analysis.

    abstract::Genetic diversity among ethnic groups is studied by comparing the genetic fingerprint of the examined groups. This index is constructed by aggregating the differential frequencies of various marker characteristics. Recent advances in the study of human biological rhythms may provide new indexes that will complement th...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:

    authors: Ticher A,Zoossmann-Diskin A,Haus E,Sackett-Lundeen L,Ashkenazi IE

    更新日期:1995-10-01 00:00:00

  • Evolutionary relationships between black South American and African populations.

    abstract::Data related to ten protein genetic loci expressed in blood obtained from four South American black populations were compared with data from seven African countries. Estimates of admixture among South American blacks were revised, and several indexes of gene diversity and genetic distances between the 11 populations w...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:

    authors: Bortolini MC,Weimer Tde A,Salzano FM,Callegari-Jacques SM,Schneider H,Layrisse Z,Bonatto SL

    更新日期:1995-08-01 00:00:00

  • Time series analysis of the epidemiological transition in Minorca, 1634-1997.

    abstract::Autoregressive integrated moving average (ARIMA) models provide a powerful tool for detecting seasonal patterns in mortality statistics. The strength of ARIMA models lies in their ability to reveal complex structures of temporal interdependence in time series. Moreover, changes in model parameters provide an empirical...

    journal_title:Human biology

    pub_type: 历史文章,杂志文章

    doi:10.1353/hub.2007.0006

    authors: Muñoz-Tudurí M,García-Moro C,Walker PL

    更新日期:2006-10-01 00:00:00

  • Isonymy structure of Sucre and Táchira, two Venezuelan states.

    abstract::The isonymy structure of two Venezuelan states, Sucre and Táchira, is described using the surnames of the Register of Electors updated in 1991. The frequency distribution of surnames pooled together by sex was obtained for the 57 counties of Sucre and the 52 counties of Táchira, based on total population sizes of 158,...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:

    authors: Rodríguez-Larralde A,Barrai I

    更新日期:1997-10-01 00:00:00

  • Complement components C2, C3, and C4 (C4A and C4B) and BF polymorphisms in populations of the Indian subcontinent.

    abstract::Genetic polymorphisms of the complement components (five loci: C2, C3, C4A, C4B, and BF) have been investigated in the Telugu-speaking Hindu population of Hyderabad, Andhra Pradesh, India, and the Bangali-speaking Muslim population of Dacca, Bangladesh. The available data are compared to understand the genetic variati...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:

    authors: Ad'hiah AH,Papiha SS

    更新日期:1996-10-01 00:00:00

  • Sex ratio at reproductive age: changes over the last century in the Italian population.

    abstract::The radical improvement in living conditions experienced in Italy during the last century caused a reduction in male extra-mortality during the prereproductive years. As a consequence, a progressive increase in the sex ratio at the beginning of the reproductive age (15-19 years) occurred, so that in recent times the s...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:10.1353/hub.2001.0014

    authors: Ulizzi L,Astolfi P,Zonta LA

    更新日期:2001-02-01 00:00:00

  • Low-molecular-weight acid phosphatase (ACP1), obesity, and blood lipid levels in subjects with non-insulin-dependent diabetes mellitus.

    abstract::Low-molecular-weight acid phosphatase (ACP1) is a polymorphic protein-tyrosine phosphatase present in all human tissues, including adipocytes. A positive association between the low-activity ACP1*A/*A genotype and extreme body mass index has previously been shown by us in obese subjects from the population of Rome. We...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:

    authors: Lucarini N,Antonacci E,Bottini N,Gloria Bottini F

    更新日期:1997-08-01 00:00:00

  • Ethnicity and type 2 diabetes in Rio de Janeiro, Brazil, with a review of the prevalence of the disease in Amerindians.

    abstract::To what extent can ethnic factors contribute to the prevalence of type 2 diabetes and impaired glucose tolerance (IGT) in an urban Brazilian population? Conversely, how can environmental factors such as diet change these prevalences in a given ethnic group, in this case Brazilian Indians? To answer these questions est...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:

    authors: Palatnik M,da Silva Júnior WA,Estalote AC,de Oliveira JE,Milech A,Zago MA

    更新日期:2002-08-01 00:00:00

  • Autosomal STR variation in five Austronesian populations.

    abstract::Human population characteristics at the genetic level are integral to both forensic biology and population genetics. This study evaluates biparental microsatellite markers in five Austronesian-speaking groups to characterize their intra- and interpopulation differences. Genetic diversity was analyzed using 15 short ta...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:10.1353/hub.2006.0019

    authors: Shepard EM,Chow RA,Suafo'a E,Addison D,Pérez-Miranda AM,Garcia-Bertrand RL,Herrera RJ

    更新日期:2005-12-01 00:00:00

  • Shape variability and classification of human hair: a worldwide approach.

    abstract::Human hair has been commonly classified according to three conventional ethnic human subgroups, that is, African, Asian, and European. Such broad classification hardly accounts for the high complexity of human biological diversity, resulting from both multiple and past or recent mixed origins. The research reported he...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:10.1353/hub.2007.0045

    authors: De la Mettrie R,Saint-Léger D,Loussouarn G,Garcel A,Porter C,Langaney A

    更新日期:2007-06-01 00:00:00

  • Determinants of birth interval in a rural Mediterranean population (La Alpujarra, Spain).

    abstract::The fertility pattern, in terms of birth intervals, in a rural population not practicing contraception belonging to La Alta Alpujarra Oriental (southeast Spain) is analyzed. During the first half of the 20th century, this population experienced a considerable degree of geographical and cultural isolation. Because of t...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:

    authors: Polo V,Luna F,Fuster V

    更新日期:2000-10-01 00:00:00

  • Age structure and sex-biased mortality among Herero pastoralists.

    abstract::Details of the population pyramid of living Herero and Mbanderu of Botswana suggest that infant and childhood mortality of males has been substantially greater than that of females. Direct tests from reproductive histories show that the hazard ratio is approximately 3 to 1 in favor of female survival in infancy and 2 ...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:

    authors: Harpending HC,Pennington R

    更新日期:1991-06-01 00:00:00

  • Genetic diversity of serum proteins in some muslim populations of India.

    abstract::The Muslim population of India is known for its historical and socioreligious significance. Literature on the genetic structure of this segment of India's population is scanty. Therefore we have investigated the allele frequency distribution of haptoglobin (HP) and transferrin (TF) phenotypes among the Muslims to expl...

    journal_title:Human biology

    pub_type: 杂志文章

    doi:10.3378/1534-6617-80.5.501

    authors: Ahmad R,Alam A,Fatima F,Hasnain AU

    更新日期:2008-10-01 00:00:00