Abstract:
:HLA-DQB1*0302 allele frequency is increased in liver graft recipients with acute rejection. We investigated polymorphism in the upstream regulatory regions (URRs) of the DQB1 gene to determine whether polymorphism in the DQB1 promoter region influences liver graft acceptance. A combination of typing protocols based on the polymerase chain reaction were used in 103 first-time liver transplants and 108 healthy Spanish controls. The QBP3.21 allele frequency and QBP3.21-DQB1*0302 haplotype were significantly different in recipients with acute rejection compared to those with good graft acceptance and to controls. Of major interest for acute rejection development are the promoter "splits" of DQB1*0302 (QBP3.21, QBP3.22, and QBP3.3 alleles), which are in linkage disequilibrium with DQB1*0302. The promoter splits were equally distributed in all groups. Thus, although there are significant differences in the frequencies of the QBP alleles and QBP-DQB1 haplotypes between recipients with and without acute rejection and controls, the composition of these haplotypes is essentially the same in all groups. In conclusion, our data show that the polymorphism in the DQB1 promoter region does not clearly influence liver graft acceptance, and, as occurs in other populations, QBP alleles exhibit strong linkage disequilibrium with the DQB1 locus.
journal_name
Hum Bioljournal_title
Human biologyauthors
Muro M,Herrero N,Marin L,Torío A,Minguela A,Sánchez-Bueno F,García-Alonso AM,Alvarez-López MRdoi
10.1353/hub.2001.0088keywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
845-54issue
6eissn
0018-7143issn
1534-6617journal_volume
73pub_type
杂志文章相关文献
HUMAN BIOLOGY文献大全abstract::We evaluate the blood pressure profile in relation to selected biological, behavioral, and socioeconomic factors among the Lepchas, a tribal population of Asian origin inhabiting the Dzongu area of northern Sikkim. The results show that mean systolic and diastolic blood pressures of Lepcha adults (aged 19 years and ol...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
abstract::Autoregressive integrated moving average (ARIMA) models provide a powerful tool for detecting seasonal patterns in mortality statistics. The strength of ARIMA models lies in their ability to reveal complex structures of temporal interdependence in time series. Moreover, changes in model parameters provide an empirical...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:10.1353/hub.2007.0006
更新日期:2006-10-01 00:00:00
abstract::Hematocrit values are normally higher in natives living at high altitude than in natives living at sea level. Here, we have determined the hematocrit levels in relation to adrenal androgens in children living at altitudes of 150 m and 3400 m above sea level. The data demonstrate no association between serum adrenal an...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::Craniofacial variation is investigated in Latin America and the Caribbean. The samples included in this study are two historic and one prehistoric sample from Ecuador; prehistoric and modern Cuban samples; a prehistoric Peruvian sample; two prehistoric Mexican samples and one contemporary admixed Mexican sample; a 16t...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:10.1353/hub.2003.0010
更新日期:2002-12-01 00:00:00
abstract::Recent studies have expanded and refined the founding haplogroups of the Americas using whole mitochondrial (mtDNA) genome analysis. In addition to pan-American lineages, specific variants have been identified in a number of studies that show higher frequencies in restricted geographical areas. To further characterize...
journal_title:Human biology
pub_type: 杂志文章
doi:10.13110/humanbiology.87.1.0029
更新日期:2015-01-01 00:00:00
abstract::Isoelectric focusing was used to investigate the genetic variants of the human plasma orosomucoid ORM1 and ORM2 gene loci in samples of Egyptians, Sudanese, and Qataris. The study populations were classified into 28 ORM phenotypes determined by 10 ORM1 and 9 ORM2 alleles that included 2 new alleles, designated ORM1*B1...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract::We used 15 short tandem repeat (STR) loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, VWA, TPOX, D18S51, D5S818, and FGA) to genetically characterize 361 individuals from 11 indigenous populations (Amuzgo, Chinanteco, Chontal, Huave, Mazateco, Mixe, Mixteco, Triqui, Zapoteco de...
journal_title:Human biology
pub_type: 杂志文章
doi:10.3378/027.082.0405
更新日期:2010-08-01 00:00:00
abstract::Large-scale genotyping and next-generation sequencing techniques have allowed great advances in the field of molecular genetics. Numerous common variants of low impact have been associated with many complex human traits and diseases, such as bipolar disorder and schizophrenia. Although they may exert a greater impact ...
journal_title:Human biology
pub_type: 杂志文章
doi:10.13110/humanbiology.88.2.0109
更新日期:2016-04-01 00:00:00
abstract::Details of the population pyramid of living Herero and Mbanderu of Botswana suggest that infant and childhood mortality of males has been substantially greater than that of females. Direct tests from reproductive histories show that the hazard ratio is approximately 3 to 1 in favor of female survival in infancy and 2 ...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00
abstract::To what extent can ethnic factors contribute to the prevalence of type 2 diabetes and impaired glucose tolerance (IGT) in an urban Brazilian population? Conversely, how can environmental factors such as diet change these prevalences in a given ethnic group, in this case Brazilian Indians? To answer these questions est...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract::Low-molecular-weight acid phosphatase (ACP1) is a polymorphic protein-tyrosine phosphatase present in all human tissues, including adipocytes. A positive association between the low-activity ACP1*A/*A genotype and extreme body mass index has previously been shown by us in obese subjects from the population of Rome. We...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1997-08-01 00:00:00
abstract::The method of isonymy, developed by Crow and Mange for estimating inbreeding from surname frequencies, requires an assumption that has not been appreciated: It is necessary to assume that all males in some ancestral generation, the founding stock, had unique surnames. Because this assumption is seldom justified in rea...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract::Dermatoglyphic traits have been used to assess population affinities and structure. Here, we describe the digital patterns of four Eskimo populations from Alaska: two Yupik-speaking villages from St. Lawrence Island and two Inupik groups presently residing on mainland Alaska. For a broader evolutionary perspective, th...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::Genetic diversity among ethnic groups is studied by comparing the genetic fingerprint of the examined groups. This index is constructed by aggregating the differential frequencies of various marker characteristics. Recent advances in the study of human biological rhythms may provide new indexes that will complement th...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::Human hair has been commonly classified according to three conventional ethnic human subgroups, that is, African, Asian, and European. Such broad classification hardly accounts for the high complexity of human biological diversity, resulting from both multiple and past or recent mixed origins. The research reported he...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2007.0045
更新日期:2007-06-01 00:00:00
abstract::The theoretical literature on human population dispersal processes at the large time and space scale is reviewed, including references to and discussions of relevant empirical data. The basic Fisher-KPP reaction-diffusion system is summarized for the single population situation, and developments relating to the Allee ...
journal_title:Human biology
pub_type: 杂志文章,评审
doi:10.3378/027.081.0302
更新日期:2009-04-01 00:00:00
abstract::Surnames of parents and grandparents were collected from 1993 children in the primary schools of the thirteen Italo-Greco communes that lie in two areas, four communes in Reggio Calabria in the "toe" of Italy and nine in Lecce in the "heel." The coefficients of relationship by isonymy show almost no relationship betwe...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::We have studied variation at 24 microsatellite markers among 50 individuals from each of three endogamous groups, Bhargavas, Chaturvedis, and non-Bhargava, non-Chaturvedi Brahmins of Uttar Pradesh, India. The number of alleles at the loci tested varied from 4 to 11, with an average of 6 at each locus. Heterozygosity w...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2003.0014
更新日期:2003-02-01 00:00:00
abstract::The use of ancient DNA techniques in human studies has been hampered by problems of contamination with modern human DNA. The main problem has been that the object of study belongs to the same species as the observer, and the complete elimination of the contamination risk is seemingly unlikely. Contamination has even b...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:10.1353/hub.2001.0069
更新日期:2001-10-01 00:00:00
abstract::The coefficient of relationship by isonymy Ri is a good indicator of similarities between and within populations by means of identity of surnames. In this study we present the results of an analysis of Ri obtained using two surnames for each person in two small Venezuelan populations of African origin: Birongo and La ...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract::Involvement of genetic factors in determining bone mineral density (BMD) is doubtless. However, the exact nature of the genes governing BMD variation and sources for genetic determination of BMD of different parts of bone (compact and cancellous) have not been completely studied. The results of the complex segregation...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::Genetic polymorphisms of the complement components (five loci: C2, C3, C4A, C4B, and BF) have been investigated in the Telugu-speaking Hindu population of Hyderabad, Andhra Pradesh, India, and the Bangali-speaking Muslim population of Dacca, Bangladesh. The available data are compared to understand the genetic variati...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::To determine the origin of sickle cell mutation in different ethnic groups living in southern Iran, we studied the haplotype background of the betaS and betaA genes in subjects from the provinces of Fars, Khuzestan, Bushehr, Hormozgan, and Kerman and from the islands of Khark and Qeshm. beta-globin gene cluster haplot...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2007.0016
更新日期:2006-12-01 00:00:00
abstract::A major goal in anthropological genetics is the assessment of the effects of different microevolutionary forces. Harpending and Ward (1982) developed a model that aids in this effort by comparing observed and expected heterozygosity within populations in a local region. The expected heterozygosity within a population ...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
abstract::There has been a lack of agreement on the variation in and the correlates of menstrual cycle length in the literature. A total of 2566 women from rural and urban areas in one district of Tamil Nadu in southern India were studied prospectively to identify correlates of menstrual cycle length. Rural women had higher odd...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::The primary purpose of this research is to collate, compare, and discuss the presently available data for head and face dimensions among Korean and Japanese ethnic groups. Classification of Korean male and female head and face types is simpler than classification of Japanese subjects. Male groups have more statistical...
journal_title:Human biology
pub_type: 杂志文章
doi:10.3378/1534-6617-80.3.313
更新日期:2008-06-01 00:00:00
abstract::Low fertility among nomadic !Kung foragers of the northern Kalahari Desert of Botswana has been hypothesized to be an adaptation to scarcity of food. However, a comparison of !Kung fertility before and after a transition to a more sedentary lifestyle indicates that more food did not increase fertility. An examination ...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::A random sample of death records of adult males from the period 1967 to 1970 was chosen from the South Australian Registry of Births, Deaths, and Marriages. The natural parents of these individuals were identified by cross-referencing to birth certificates, and an extensive search was made of the death records for the...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::"Pygmy populations" are recognized in several places over the world, especially in Western Africa and in Southeast Asia (Philippine "negritos," for instance). Broadly defined as "small-bodied Homo sapiens" (compared with neighboring populations), their origins and the nature of the processes involved in the maintenanc...
journal_title:Human biology
pub_type: 杂志文章
doi:10.3378/027.085.0303
更新日期:2013-02-01 00:00:00
abstract::I describe the developmental, metric, morphologic, and pathologic features of deciduous dentition in a terminal Late Archaic (c. 3000 B.P.) Native American population in Ohio. Development of deciduous dentition in this Late Archaic population is stable with little sequence variation. The pattern of development (ldc, l...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:
更新日期:1990-04-01 00:00:00