Abstract：
:Several studies have shown evidence of an association between the *4 allele of apolipoprotein E (APOE) and coronary heart disease (CHD) in different populations. We determined the APOE genotype and total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDLC) values in 189 patients with angiographically evaluated atherosclerosis. The APOE*4 allele was found to be statistically significantly more frequent (odds ratio, 1.93; 95% confidence interval, 1.12-3.32) among male patients than in a randomly chosen population-based sample. No significant difference was found when female patients were compared to the general population. The APOE*4 allele was found primarily among young (30-45-year-old) male patients (p < 0.04). Despite the ascending linear tendency of the mean TC values for genotypes APOE*2/*3, APOE*3/*3, and APOE*3/ *4 reported in our case population, no differences were observed among our patients. We conclude that the APOE*4 allele is associated with an increased risk for atherosclerotic vascular disease, that this association has an age-dependent effect, and that it acts as a genetic factor that increases susceptibility to developing the disease in young to middle-aged male adults in our population.
journal_name
Hum Bioljournal_title
Human biologyauthors
Bañares VG,Peterson G,Aguilar D,Gulayin R,Sisu E,Wyszynski DF,Pivetta OH,Tavella MJdoi
10.1353/hub.2005.0036keywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
247-56issue
2eissn
0018-7143issn
1534-6617journal_volume
77pub_type
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