Abstract：
:A mismatch distribution is a tabulation of the number of pairwise differences among all DNA sequences in a sample. In a population that has been stationary for a long time these distributions from nonrecombinant DNA sequences become ragged and erratic, whereas a population that has been growing generates mismatch distributions that are smooth and have a peak. The position of the peak reflects the time of the population growth. The signature of an ancient population expansion is apparent even in the low-resolution mtDNA typings described by Merriwether et al. (1991). The smoothness of the mismatch distribution, an indicator of population expansion, is hardly affected by population structure, whereas mean sequence divergence increases in a pooled sample from highly isolated subpopulations.
journal_name
Hum Bioljournal_title
Human biologyauthors
Harpending HCsubject
Has Abstractpub_date
1994-08-01 00:00:00pages
591-600issue
4eissn
0018-7143issn
1534-6617journal_volume
66pub_type
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