Abstract:
:A Buryat population consisting of seven tribal groups in eastern Mongolia has been screened to determine the frequency distribution of different apolipoprotein E and H alleles (APOE and APOH, genes) coding for common isoforms and their association with quantitative plasma lipid levels. Allele frequencies at the APOE locus in 125 healthy Buryat aged 17 to 73 years were highest for APOE*3 (0.804), followed by APOE*4 (0.164) and APOE*2 (0.032). The APOH locus had high frequencies of APOH*2 (0.912) and APOH*3 (0.088). APOH*1 was not detected. No significant differences were observed in the overall APOE allele frequencies between the Buryat and the Siberian Evenki, Inuits, and Indians in Asia, or with some European whites. The frequency distribution of the overall APOH alleles of the Buryat was similar to that of the Japanese in Asia. Overall plasma lipid levels of the Buryat (males aged 20 to 73 years, females aged 21 to 64 years) were considerably lower, comparable to those of the Evenki. The APOE*4/E*3 males had significantly high total- and LDL-cholesterol levels compared with the APOE*3/E*3 males (p < 0.025 and p < 0.01, respectively). No significant effects of the APOH genotypes on any of the plasma lipid levels were observed. In particular, our data regarding APOE suggest that the Buryat are genetically close in allele frequencies to the Evenki and Inuits, but differ from them in the association of genotype APOE*4/E*3 with cholesterol levels.
journal_name
Hum Bioljournal_title
Human biologyauthors
Tsunoda K,Harihara S,Dashnyam B,Semjidmaa D,Yamaguchi Y,Tanabe Y,Sakai N,Sato A,Sato Kdoi
10.1353/hub.2002.0058keywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
659-71issue
5eissn
0018-7143issn
1534-6617journal_volume
74pub_type
杂志文章相关文献
HUMAN BIOLOGY文献大全abstract::We analyze the possible effect of gene flow on the genetic structure of present-day Mexicans. For this purpose we reviewed previous admixture estimates for various Indian and Mestizo groups. Several facts seem clear: (1) There are no pure Indian groups in Mexico, because all Indian groups show variable degrees of admi...
journal_title:Human biology
pub_type: 杂志文章,多中心研究
doi:
更新日期:1996-06-01 00:00:00
abstract::GM and KM immunoglobulin (Ig) allotypes were tested in 118 autochthonous Basques from northern Navarre. The results are compared to those obtained for the same genetic markers in 6 other Basque subpopulations, 3 from Spain (Guipúzcoa, Vizcaya, and Alava) and 3 from France: Macaye, Saint-Jean Pied de Port, and Mauleon....
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00
abstract::Isoelectric focusing was used to investigate the genetic variants of the human plasma orosomucoid ORM1 and ORM2 gene loci in samples of Egyptians, Sudanese, and Qataris. The study populations were classified into 28 ORM phenotypes determined by 10 ORM1 and 9 ORM2 alleles that included 2 new alleles, designated ORM1*B1...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract::Two microsatellites (CD4 and F13A1) were investigated in seven Brazilian populations: one group each of European- and African-derived subjects from Porto Alegre, southern Brazil, and five Amerindian tribes (three Tupi-Mondé speaking [Gavião, Surui, and Zoró], one Macro-Gê [Xavante], and one Carib [Wai-Wai]). For both ...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract::Preston's two-census method of demographic estimation is applied to three pairs of reconstructed censuses from the records of a migrating Mennonite church congregation covering the period 1780-1890. The three pairs of censuses correspond to three periods (1780-1790, 1850-1860, and 1880-1890) and to stays in three sett...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::HLA-DQB1*0302 allele frequency is increased in liver graft recipients with acute rejection. We investigated polymorphism in the upstream regulatory regions (URRs) of the DQB1 gene to determine whether polymorphism in the DQB1 promoter region influences liver graft acceptance. A combination of typing protocols based on...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2001.0088
更新日期:2001-12-01 00:00:00
abstract::Low-molecular-weight acid phosphatase (ACP1) is a polymorphic protein-tyrosine phosphatase present in all human tissues, including adipocytes. A positive association between the low-activity ACP1*A/*A genotype and extreme body mass index has previously been shown by us in obese subjects from the population of Rome. We...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1997-08-01 00:00:00
abstract::Mitochondrial DNA haplotype studies have been useful in unraveling the origins of Native Americans. Such studies are based on restriction site and intergenic deletion/insertion polymorphisms, which define four main haplotype groups common to Asian and American populations. Several studies have characterized these line...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2002.0022
更新日期:2002-04-01 00:00:00
abstract::It was predicted that at the state level early neonatal (0-6 days) mortality rates and rates for sudden infant death syndrome (SIDS) in the age range 7-364 days would be negatively correlated. Using published data for each of the 50 states and the District of Columbia over the 5-year period 1980-1984, the actual corre...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract::Twelve healthy, anal-receptive, homosexual Caucasian males who were seronegative for HIV antibody were typed for HLA-DR antigens. Flow cytometry was used to immunophenotype peripheral blood lymphocytes bearing the CD4, CD8, LEU7, and combined CD8 and LEU7 antigens. These individuals had reported a large number of sexu...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract::Growth is a complex process composed of distinct phases over the course of childhood. Although the pubertal growth spurt has received the most attention from auxologists and pediatricians, the midchildhood growth spurt has been less well studied. The midchildhood growth spurt refers to a relatively small increase in g...
journal_title:Human biology
pub_type: 杂志文章
doi:10.3378/1534-6617-80.6.623
更新日期:2008-12-01 00:00:00
abstract::The amiloride-sensitive epithelial sodium channel is a highly selective sodium channel that constitutes the rate-limiting step of sodium reabsorption in distal nephrons. It consists of at least 3 subunits (alpha, beta, and gamma) of similar structure and plays an important role in sodium and fluid homeostasis. Defects...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract::We present the most comprehensive genetic characterization to date of five Fijian island populations: Viti Levu, Vanua Levu, Kadavu, the Lau Islands, and Rotuma, including nonrecombinant Y (NRY) chromosome and mitochondrial DNA (mtDNA) haplotypes and haplogroups. As a whole, Fijians are genetically intermediate betwee...
journal_title:Human biology
pub_type: 杂志文章
doi:10.13110/humanbiology.88.3.0232
更新日期:2016-07-01 00:00:00
abstract::Involvement of genetic factors in determining bone mineral density (BMD) is doubtless. However, the exact nature of the genes governing BMD variation and sources for genetic determination of BMD of different parts of bone (compact and cancellous) have not been completely studied. The results of the complex segregation...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::The Sicilian population has a complex history of colonization and invasions that have influenced the genetic composition of the nine provinces of the island. Because surnames are patrilineally inherited, they simulate a Y-chromosome nonrecombinant genetic locus. We used surname data and a specific sampling strategy to...
journal_title:Human biology
pub_type: 杂志文章
doi:10.1353/hub.2005.0015
更新日期:2004-12-01 00:00:00
abstract::We summarize the results of a field and laboratory research program (1999-2006) in the Aleutian Islands on the origins of the inhabitants of the archipelago and the genetic structure of these populations. The Aleuts show closest genetic affinity to the contemporary Siberian Eskimos and Chukchi of Chukotka and differ s...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:10.3378/027.082.0511
更新日期:2010-12-01 00:00:00
abstract::The aim of this study is to individualize potential differences between two cranial regions used to differentiate human populations. We compared the neurocranium and the facial skeleton using skulls from the Great Hungarian Plain. The skulls date to the 1st-11th centuries, a long space of time that encompasses seven a...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:10.3378/027.082.0103
更新日期:2010-02-01 00:00:00
abstract::Autoregressive integrated moving average (ARIMA) models provide a powerful tool for detecting seasonal patterns in mortality statistics. The strength of ARIMA models lies in their ability to reveal complex structures of temporal interdependence in time series. Moreover, changes in model parameters provide an empirical...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:10.1353/hub.2007.0006
更新日期:2006-10-01 00:00:00
abstract::We describe the gene frequency distributions for 29 different blood group, serum, and erythrocytic proteins for three Mennonite communities from Kansas and Nebraska and compare their gene frequencies with those of Amish, Hutterite, and Mennonite populations using the topological method of Harpending and Jenkins (1973)...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract::Anthropoid phylogeny has been characterized by dramatic increases in relative brain size. Given the importance of genetic mechanisms in evolution, quantitative genetic analyses of the biological concomitants of relative brain size variation should greatly augment our understanding of this phylogenetic phenomenon. In h...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::The primary purpose of this research is to collate, compare, and discuss the presently available data for head and face dimensions among Korean and Japanese ethnic groups. Classification of Korean male and female head and face types is simpler than classification of Japanese subjects. Male groups have more statistical...
journal_title:Human biology
pub_type: 杂志文章
doi:10.3378/1534-6617-80.3.313
更新日期:2008-06-01 00:00:00
abstract::The polymorphism of human mitochondrial DNA (mtDNA) was studied in 118 unrelated Greeks (from northern Greece) using total blood cell DNA and the restriction enzymes HpaI, BamHI, HaeII, MspI, AvaII, and HincII. One new morph was identified for MspI (named MspI morph 18Gr) and is the result of a mutation in a previousl...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::A reanalysis of the family growth study of Pearson and Lee (1903) leads to an explanation of the inheritance of height other than the one that has been offered until now. By acknowledging that the father may be incorrectly identified, this new analysis provides a more relevant explanation of the data: it fits parallel...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract::I describe the developmental, metric, morphologic, and pathologic features of deciduous dentition in a terminal Late Archaic (c. 3000 B.P.) Native American population in Ohio. Development of deciduous dentition in this Late Archaic population is stable with little sequence variation. The pattern of development (ldc, l...
journal_title:Human biology
pub_type: 历史文章,杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::In one of the truly classic works in anthropological genetics, Frank Livingstone established the interrelationships between agriculture, mosquito ecology, malaria, and, consequently, the frequencies of sickle cell hemoglobin in West Africa. A major inference from Livingstone's study was the recency of malaria as a sel...
journal_title:Human biology
pub_type: 历史文章,杂志文章,评审
doi:10.1353/hub.2003.0053
更新日期:2003-08-01 00:00:00
abstract::Genetic polymorphisms of the complement components (five loci: C2, C3, C4A, C4B, and BF) have been investigated in the Telugu-speaking Hindu population of Hyderabad, Andhra Pradesh, India, and the Bangali-speaking Muslim population of Dacca, Bangladesh. The available data are compared to understand the genetic variati...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::We summarize several studies, from the last 10 years, of temporal changes and rural-urban differences in the risk factors of cardiovascular disease (CVD) in China to indicate the influences of economic modernization. Two national blood pressure surveys have shown that the prevalence of hypertension increased from 5.1%...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::We investigated the relationship between the dispersal potential of a hominin population, its local-scale foraging strategies, and the characteristics of the resource environment using an agent-based modeling approach. In previous work we demonstrated that natural selection can favor a relatively low capacity for asse...
journal_title:Human biology
pub_type: 杂志文章
doi:10.13110/humanbiology.87.3.0205
更新日期:2015-07-01 00:00:00
abstract::Recent research has questioned whether the European Black Death of 1347-1351 could possibly have been caused by the bubonic plague bacillus Yersinia pestis, as has been assumed for over a century. Central to the arguments both for and against involvement of Y. pestis has been a comparison of the temporal dynamics obse...
journal_title:Human biology
pub_type: 传,历史文章,杂志文章
doi:10.1353/hub.2003.0067
更新日期:2003-08-01 00:00:00
abstract::A major goal in anthropological genetics is the assessment of the effects of different microevolutionary forces. Harpending and Ward (1982) developed a model that aids in this effort by comparing observed and expected heterozygosity within populations in a local region. The expected heterozygosity within a population ...
journal_title:Human biology
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00