A negative regulatory element in the rat dopamine beta-hydroxylase gene contributes to the cell type specificity of expression.

abstract：:Studies suggest that activation of phosphoinositide 3-kinase-Akt may protect against neuronal cell death in Alzheimer's disease (AD). Here, however, we provide evidence of increased Akt activation, and hyperphosphorylation of critical Akt substrates in AD brain, which link to AD pathogenesis, suggesting that treatment...

journal_title：Journal of neurochemistry

authors： Griffin RJ,Moloney A,Kelliher M,Johnston JA,Ravid R,Dockery P,O'Connor R,O'Neill C

更新日期：2005-04-01 00:00:00

abstract：:Glycogen synthase kinase 3 (GSK3) plays important roles in Wnt and insulin signaling, cell fate determination, and Alzheimer-like tau phosphorylation. We discovered an isoform of tau protein kinase I (TPKI)/GSK3beta with a 13 amino acid insert in the catalytic domain owing to alternative splicing. The alternative tran...

journal_title：Journal of neurochemistry

authors： Mukai F,Ishiguro K,Sano Y,Fujita SC

更新日期：2002-06-01 00:00:00

abstract：:The phosphorylation of microtubule-associated protein 2 (MAP2) by four different kinases was studied in vitro to determine whether MAP2 is phosphorylated in its tubulin binding region or in the microtubule projection portion. Fragments corresponding to both regions of MAP2 were produced not only by chymotrypsin or try...

journal_title：Journal of neurochemistry

authors： Hernández MA,Wandosell F,Avila J

更新日期：1987-01-01 00:00:00

abstract：:Although the excitatory action of GABA has been shown to activate the expression of brain-derived neurotrophic factor (BDNF), its molecular mechanisms remain unclear. Using cultured rat cortical cells, we here demonstrated that GABA induced Bdnf mRNA expression mainly via L-type voltage-dependent Ca(2+) channels (L-VD...

journal_title：Journal of neurochemistry

authors： Fukuchi M,Kirikoshi Y,Mori A,Eda R,Ihara D,Takasaki I,Tabuchi A,Tsuda M

更新日期：2014-10-01 00:00:00

abstract：:[3H]Cocaine dissociates from its binding sites in the mouse cerebral cortex with a half-time of 25 s. The dissociation kinetics in the striatum is consonant with the presence of two populations of sites with dissociation half times of 2 s and 27 s, comprising 88% and 12%, respectively, of the total binding sites. On t...

journal_title：Journal of neurochemistry

authors： Reith ME,Sershen H,Lajtha A

更新日期：1986-01-01 00:00:00

abstract：:Purified tribulin, an endogenous monoamine oxidase (MAO) inhibitor, has been identified by direct probe insertion mass spectrometry as the indole-2,3-dione, isatin. A gas chromatographic-mass spectrometric assay for isatin has been developed and used to measure its relatively high concentrations in unpurified human ur...

journal_title：Journal of neurochemistry

authors： Glover V,Halket JM,Watkins PJ,Clow A,Goodwin BL,Sandler M

更新日期：1988-08-01 00:00:00

abstract：:This study investigates the implication of mitochondria- and caspase-dependent pathways in the death of retinal neurones exposed to the neurosteroid pregnenolone sulfate (PS) shown to evoke apoptosis and contribute to amplification and propagation of excitotoxicity. After a brief PS challenge of intact retinas, caspas...

journal_title：Journal of neurochemistry

authors： Cascio C,Guarneri R,Russo D,De Leo G,Guarneri M,Piccoli F,Guarneri P

更新日期：2002-12-01 00:00:00

abstract：:Tamoxifen has been found to be neuroprotective in both transient and permanent experimental ischemic stroke. However, it remains unknown whether this agent shows a similar beneficial effect after spinal cord injury (SCI), and what are its underlying mechanisms. In this study, we investigated the efficacy of tamoxifen ...

journal_title：Journal of neurochemistry

authors： Tian DS,Liu JL,Xie MJ,Zhan Y,Qu WS,Yu ZY,Tang ZP,Pan DJ,Wang W

更新日期：2009-06-01 00:00:00

abstract：:Ion channels are classically understood to regulate the flux of ions across the plasma membrane in response to a variety of environmental and intracellular cues. Ion channels serve a number of functions in intracellular membranes as well. These channels may be temporarily localized to intracellular membranes as a func...

journal_title：Journal of neurochemistry

authors： Dong XP,Wang X,Xu H

更新日期：2010-04-01 00:00:00

abstract：:To determine the role of reduced dopaminergic transmission for declines of forced versus spontaneous behavior, we used a model of Parkinson's disease with progressive degeneration of dopamine (DA) neurons, the MitoPark mouse. Mice were subjected to rotarod tests of motor coordination, and open field and cylinder tests...

journal_title：Journal of neurochemistry

authors： Chen YH,Hsieh TH,Kuo TT,Kao JH,Ma KH,Huang EY,Chou YC,Olson L,Hoffer BJ

更新日期：2019-07-01 00:00:00

abstract：:Extraction of rat brain membrane-associated protein kinase C with high specific activity was obtained by applying benzyl alcohol (a membrane fluidizer), EDTA, and high hydrostatic pressures. Approximately 50% of total brain-associated activity was extracted from membranes. The pressure-extracted activity had an eightf...

journal_title：Journal of neurochemistry

authors： Lester DS

更新日期：1989-06-01 00:00:00

abstract：:Thymosin beta 4 (Tβ4), a secreted 43 amino acid peptide, promotes oligodendrogenesis, and improves neurological outcome in rat models of neurologic injury. We demonstrated that exogenous Tβ4 treatment up-regulated the expression of the miR-200a in vitro in rat brain progenitor cells and in vivo in the peri-infarct are...

journal_title：Journal of neurochemistry

authors： Santra M,Chopp M,Santra S,Nallani A,Vyas S,Zhang ZG,Morris DC

更新日期：2016-01-01 00:00:00

abstract：:The isolation, characterization, and bioactivity in the feeding circuitry of a novel neuropeptide in the Aplysia californica central nervous system are reported. The 17-residue amidated peptide, NGGTADALYNLPDLEKIamide, has been termed cerebrin due to its primary location in the cerebral ganglion. Liquid chromatographi...

journal_title：Journal of neurochemistry

authors： Li L,Floyd PD,Rubakhin SS,Romanova EV,Jing J,Alexeeva VY,Dembrow NC,Weiss KR,Vilim FS,Sweedler JV

更新日期：2001-06-01 00:00:00

abstract：:The effect of ascorbic acid on Ca2+ uptake in cultured rat astrocytes was examined in the presence of ouabain and monensin, which are considered to drive the Na(+)-Ca2+ exchanger in the reverse mode. Ascorbic acid at 0.1-1 mM inhibited Na(+)-dependent Ca2+ uptake significantly but not Na(+)-dependent glutamate uptake ...

journal_title：Journal of neurochemistry

authors： Takuma K,Matsuda T,Asano S,Baba A

更新日期：1995-04-01 00:00:00

abstract：:Choline acetyltransferase activity is barely detectable in a mutant pheochromocytoma PC12 cell line, A123.7, which is deficient in protein kinase A activity. Northern blot and polymerase chain reaction analyses showed that this mutant cell line has dramatically reduced levels of choline acetyltransferase mRNA, which c...

journal_title：Journal of neurochemistry

authors： Inoue H,Li YP,Wagner JA,Hersh LB

更新日期：1995-03-01 00:00:00

abstract：:Effects of Pb(2+) on vesicular catecholamine release in intact and ionomycin-permeabilized PC12 cells were investigated using carbon fibre microelectrode amperometry. Changes in intracellular Pb(2+) and Ca(2+) were measured from indo-1 fluorescence by confocal laser scanning microscopy. Depolarization of intact cells ...

journal_title：Journal of neurochemistry

authors： Westerink RH,Vijverberg HP

更新日期：2002-03-01 00:00:00

abstract：:Somatodendritic voltage-dependent K(+) currents (Kv4.2) channels mediate transient A-type K(+) currents and play critical roles in controlling neuronal excitability. Accumulating evidence has indicated that Kv4.2 channels are key regulatory components of the signaling pathways that lead to synaptic plasticity. In cont...

journal_title：Journal of neurochemistry

authors： Lei Z,Deng P,Xu ZC

更新日期：2008-07-01 00:00:00

abstract：:S-100 proteins are a group of three 21-kilodalton, acidic, Ca2+-binding proteins of the "E-F hand" type shown to regulate several cell activities, including microtubule (MT) assembly-disassembly. We show here that S-100 proteins interact with MTs assembled from either whole microtubule protein or purified tubulin, bot...

journal_title：Journal of neurochemistry

authors： Donato R,Giambanco I

更新日期：1989-04-01 00:00:00

abstract：:P-glycoprotein (P-gp), an adenosine triphosphate (ATP)-binding cassette transporter which acts as a drug efflux pump, is highly expressed at the blood-brain barrier (BBB) where it plays an important role in brain protection. Recently, P-gp has been reported to be located in the caveolae of multidrug-resistant cells. I...

journal_title：Journal of neurochemistry

authors： Jodoin J,Demeule M,Fenart L,Cecchelli R,Farmer S,Linton KJ,Higgins CF,Béliveau R

更新日期：2003-11-01 00:00:00

abstract：:The dopamine transporter is a plasma membrane protein that controls extracellular concentrations of the neurotransmitter dopamine. The physiological importance of the DAT provides the impetus for studies aimed at understanding the molecular mechanisms underlying regulation of the DAT gene. In this study, we identified...

journal_title：Journal of neurochemistry

authors： Wang J,Bannon MJ

更新日期：2005-04-01 00:00:00

abstract：:Preincubation of murine neuroblastoma cells (clone N1E-115) with terbium chloride resulted in a significant potentiation of carbachol-mediated increase in cyclic GMP formation. This effect was accompanied by a shift of the peak response from 30 s to 120 s and a 6-fold decrease in carbachol concentration producing half...

journal_title：Journal of neurochemistry

authors： El-Fakahany EE,Pfenning M,Richelson E

更新日期：1984-03-01 00:00:00

abstract：:Carbamylcholine stimulated phospholipase C activity in astrocytes in primary culture from the mesencephalon but not from the striatum or cerebral cortex of the mouse embryo. An alpha 1-adrenergic-mediated response was observed in all astrocyte populations. 2-Chloroadenosine potentiated the alpha 1-adrenergic response ...

journal_title：Journal of neurochemistry

authors： el-Etr M,Cordier J,Torrens Y,Glowinski J,Prémont J

更新日期：1989-03-01 00:00:00

abstract：:Serotonin-1A (5-HT(1A) receptors in the dorsal raphe nucleus (DRN) function as somatodendritic autoreceptors, and therefore play a critical role in controlling serotonergic cell firing and serotonergic neurotransmission. We hypothesized that a decrease in the capacity of 5-HT(1A) receptors to activate G proteins was a...

journal_title：Journal of neurochemistry

authors： Rossi DV,Burke TF,McCasland M,Hensler JG

更新日期：2008-05-01 00:00:00

abstract：:We have shown recently that the presence of albumin in astrocytes triggers the synthesis and release of oleic acid, which behaves as a neurotrophic factor for neurons. Thus, oleic acid promotes axonal growth together with the expression of the axonal growth-associated protein, GAP-43. Here we attempted to elucidate wh...

journal_title：Journal of neurochemistry

authors： Rodríguez-Rodríguez RA,Tabernero A,Velasco A,Lavado EM,Medina JM

更新日期：2004-03-01 00:00:00

abstract：:Adenosine A(1) receptors (A(1)Rs) have been characterized in primary cultures of neurons from cerebral cortex. The specific adenosine A(1) antagonist 8-cyclopentyl-1,3-[(3)H]dipropylxanthine bound to both membranes and intact cells. When saturation experiments were performed in membranes, a K(D) value of 0.76 nM and a...

journal_title：Journal of neurochemistry

authors： Ruiz MA,Escriche M,Lluis C,Franco R,Martín M,Andrés A,Ros M

更新日期：2000-08-01 00:00:00

abstract：:Cathepsin D (CTSD) deficiencies are fatal neurological diseases that in human infants and in sheep are characterized by extreme loss of neurons and myelin. To date, similar morphological evidence for myelin disruption in CTSD knockout mice has not been reported. Here, we show that CTSD deficiency leads to pronounced m...

journal_title：Journal of neurochemistry

authors： Mutka AL,Haapanen A,Käkelä R,Lindfors M,Wright AK,Inkinen T,Hermansson M,Rokka A,Corthals G,Jauhiainen M,Gillingwater TH,Ikonen E,Tyynelä J

更新日期：2010-01-01 00:00:00

abstract：:The uptake of 3',3,5-triiodo-L-thyronine (T3) and L-thyroxine (T4) by primary cultures derived from rat brain hemispheres was studied under initial velocity conditions, at 25 degrees C. Uptake of both hormones was carrier mediated and obeyed simple Michaelis-Menten kinetics. The Km of T3 uptake was very similar to tha...

journal_title：Journal of neurochemistry

authors： Chantoux F,Blondeau JP,Francon J

更新日期：1995-12-01 00:00:00

abstract：:Tryptophan hydroxylase (TPH) is the initial and rate-limiting enzyme in serotonin biosynthesis. The enzyme activity is dependent on molecular oxygen, a tetrahydropterin cosubstrate, and ferrous iron. The present study demonstrates that TPH is inhibited by a novel compound, p-ethynylphenylalanine (pEPA), produced by th...

journal_title：Journal of neurochemistry

authors： Stokes AH,Xu Y,Daunais JA,Tamir H,Gershon MD,Butkerait P,Kayser B,Altman J,Beck W,Vrana KE

更新日期：2000-05-01 00:00:00

abstract：:The two proteins reggie-1/flotillin-2 and reggie-2/flotillin-1 form microdomains at the plasma membrane and at intracellular compartments where src tyrosine kinases associate with them. Specific GPI-anchored proteins, in particular prion protein and Thy-1, co-cluster with reggie microdomains at the plasma membrane and...

journal_title：Journal of neurochemistry

authors： Stuermer CA

更新日期：2011-03-01 00:00:00

abstract：:The activation by endogenous dopamine of the inhibitory 3,4-dihydroxyphenylethylamine (dopamine) receptors modulating the electrically evoked release of [3H]acetylcholine [( 3H]ACh) and [3H]dopamine in rat striatal slices is a function of the concentration of dopamine accumulated in the synaptic cleft during electrica...

journal_title：Journal of neurochemistry

authors： Baud P,Arbilla S,Langer SZ

更新日期：1985-02-01 00:00:00