Abstract：
:Our own previous studies of the composition of the extracellular matrix of human failing hearts showed that collagen VI seems to play a major role in the origin of cardiac fibrosis. Therefore, collagen VI was investigated in more detail in tissue samples taken from clinically normal left ventricle and from myocardium failing because of dilated cardiomyopathy. Tissue sections prepared with collagen VI antibodies were examined by fluorescence microscopy using conventional or confocal laser scanning microscopy. In normal myocardium, collagen VI was located in both, endomysium and perimysium, in blood vessels it surrounded closely individual myocytes. Failing myocardium showed enlargement of the extracellular space and collagen VI was abundant. The localisation was perivascular as well as interstitial in fine or thick bundles enclosing the myocytes completely. In hearts with far progressed failure areas of replacement fibrosis containing increased amounts of collagen VI were evident. Double-staining for vimentin and collagen VI revealed a close interaction with fibroblasts. Although the function of collagen VI is not yet entirely clear it seems obvious that collagen VI plays an important role in the development of fibrosis in the failing heart.
journal_name
Herzjournal_title
Herzauthors
Mollnau H,Münkel B,Schaper Jsubject
Has Abstractpub_date
1995-04-01 00:00:00pages
89-94issue
2eissn
0340-9937issn
1615-6692journal_volume
20pub_type
杂志文章相关文献
HERZ文献大全abstract：:Electrophysiologic studies in patients with the Wolff-Parkinson-White (WPW) syndrome are performed for diagnostic and therapeutic reasons. Surface electrocardiographic leads plus intracardiac electrograms from different locations are stimultaneously recorded. Programmed electrical stimulation of the heart permits conf...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1979-02-01 00:00:00
abstract：BACKGROUND AND PURPOSE:: Drug-eluting stents (DES) have been shown to reduce the risk of in-stent stenosis, one of the major problems of percutaneous coronary intervention (PCI) with implantation of baremetal stents. DES are approved in Germany since 2002. The following study is based on data of the ALKK PCI registry a...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-008-3097-1
更新日期：2008-09-01 00:00:00
abstract：:Patients with congenital heart disease have an increased chance to suffer from brady- as well as tachyarrhythmias. The impact of these on quality of life, morbidity and mortality is more often imperative as compared to heart-healthy individuals. The substrate for these may be either congenital or acquired. Improvement...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/BF03043882
更新日期：1999-06-01 00:00:00
abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS) single-nucleotide polymorphisms have been reported to confer susceptibility to hypertension, but no consensus has been reached. The aim of this study was to investigate the association between iNOS and hypertension in a Chinese population. METHODS:This was a case-contr...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-017-4591-0
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate the clinical and imaging features of patients with cardiac rhabdomyomas associated with tuberous sclerosis complex. PATIENTS AND METHODS:The clinical and imaging characteristics of seven patients with cardiac rhabdomyomas associated with tuberous sclerosis complex between ...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-014-4078-1
更新日期：2015-06-01 00:00:00
abstract：:The American Heart Association (AHA) radically changed the recommendations regarding endocarditis prophylaxis, if patients undergo dental work. For the vast majority of patients previously considered to be at significant risk for bacterial endocarditis (especially patients with degenerative and rheumatic heart disease...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-009-3208-7
更新日期：2009-02-01 00:00:00
abstract：:Diastolic function in coronary artery disease is modified to a variable extent. There are distinct abnormalities produced during acute ischemia, and following myocardial infarction. The pathophysiology of diastolic abnormalities in these two syndromes is reviewed. During acute ischemia filling pressures of the left ve...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1991-02-01 00:00:00
abstract：:In ten patients with angiographically-documented coronary artery disease, stable angina pectoris and reproducible exercise-induced ST-segment depression, the extent and duration of antiischemic and antianginal effects of transdermal nitroglycerin patches delivering 10 mg/24 hours were investigated according to a doubl...
journal_title：Herz
pub_type： 临床试验,杂志文章
doi：
更新日期：1987-02-01 00:00:00
abstract：:It is now generally recognized that atherosclerosis is a chronic inflammatory disease, characterized by overrecruitment of leukocytes (monocytes and T-cells) to the site of inflammation. Vascular injury in response to cardiovascular risk factors promotes endothelial dysfunction, resulting in enhanced adhesion molecule...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-004-2634-9
更新日期：2004-12-01 00:00:00
abstract：:The majority of sustained ventricular tachycardias are caused by a reentry mechanism. Conditions prerequisite to a reentry circuit are electrophysiological changes, namely conduction delay and block which are incurred by virtue of changes in the myocardial tissue due to scarring, ischemia or fatty infiltration and res...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1988-06-01 00:00:00
abstract：BACKGROUND:Experimental and clinical studies have suggested that the presence of fragmented QRS complex (fQRS) is associated with various cardiovascular diseases. fQRS may predict major adverse cardiovascular events (MACE). The current meta-analysis was performed using clinical outcome studies to evaluate the role of f...
journal_title：Herz
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00059-014-4155-5
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:The beta-adrenergic receptors of the myocardium play an important role in the regulation of heart function. The beta-adrenergic receptors belong to the family of G-protein coupled receptors. Three subtypes have been distinguished (beta1-, beta2-, and beta3-adrenoceptors). The receptors consist of seven membr...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-002-2434-z
更新日期：2002-11-01 00:00:00
abstract：BACKGROUND AND AIM OF THE STUDY:The predisposition to atrial fibrillation (AF) in mitral stenosis (MS) has been demonstrated with several electrocardiographic (increased P-wave dispersion) and echocardiographic parameters (atrial electromechanical delay). Despite the improvement in P-wave dispersion after percutaneous ...
journal_title：Herz
pub_type： 临床试验,杂志文章
doi：10.1007/s00059-012-3672-3
更新日期：2013-03-01 00:00:00
abstract：:Diabetes is associated with the development of premature cardiovascular disease (CVD), which relates to the clustering of risk factors such as dyslipidaemia, hypertension, obesity and hyperglycaemia in the presence of insulin resistance. In addition, diabetes is associated with an inflammatory and pro-thrombotic envir...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-016-4414-8
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Culture-negative endocarditis is a diagnostic challenge with variable clinical presentation and protean manifestations. ETIOLOGY AND DIAGNOSIS:The two main causes why endocarditis may be culture-negative are 1. antibiotic treatment prior to obtaining blood cultures, and 2. the presence of fastidious microor...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-001-2314-y
更新日期：2001-09-01 00:00:00
abstract：:Surgical aortic valve replacement still represents the gold standard in patients with severe symptomatic aortic valve stenosis. In addition to conventional aortic valve replacement by mechanical or biological prostheses via a median sternotomy, novel approaches including minimally invasive strategies and new devices, ...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-017-4593-y
更新日期：2017-09-01 00:00:00
abstract：OBJECTS:To show all cardiac evaluations multislice computed tomography (MSCT) can perform. METHODS:MSCTs were performed on an MSCT scanner (Mx8000; Philips Medical Systems) with enhanced contrast acquisition. The reconstructed images were sent to a workstation for multiplanar reconstruction, volume rendering, and 3-D ...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-003-2443-6
更新日期：2003-02-01 00:00:00
abstract：:Disorders of the autonomic nervous control mechanisms of heart rate and vascular tone may cause syncope. Notably these are carotid sinus and vasovagal syndromes. Knowledge of their aetiology is limited. Each presents cardioinhibition and vasodepression. Pacing offers benefit in cardioinhibition and the mode required i...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1993-06-01 00:00:00
abstract：:The case presented here is intended to raise awareness of two uncommon coronary angiographic findings in the clinical context of acute coronary syndrome. The prevalence of patients presenting with spontaneous coronary dissection as the underlying cause of an ST-elevation myocardial infarction is low. It is typically f...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-011-3522-8
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Galectin-3 has been reported as a mediator of heart failure (HF) development and progression. Most studies, however, have been conducted on patients with chronic HF rather than acute HF (AHF). The aim of this study was to confirm galectin-3 as a prognostic marker in subjects with AHF and to investigate its p...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-017-4538-5
更新日期：2018-03-01 00:00:00
abstract：:New therapeutic options such as the highly active antiretroviral therapy (HAART) have significantly improved morbidity and mortality of HIV-infected patients. Consequently, age-related diseases become more manifest. In addition, HIV infection itself causes certain cardiovascular morbidity. Therefore, treatment of card...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-005-2723-4
更新日期：2005-09-01 00:00:00
abstract：:In congestive heart failure, acute administration of the converting enzyme inhibitor captopril leads to a decrease in arterial pressure, systemic vascular resistance, left ventricular filling pressure, and the end-diastolic volumes of both ventricles, as well as to an increase in cardiac index, stroke volume index, ri...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1983-04-01 00:00:00
abstract：:In a prospective double-blind study of 40 male patients requiring aorto-coronary bypass surgery, a dose of 8 ng/kg/min of PGI2 was infused throughout extracorporeal circulation (ECC) (control group: glycine buffer). Between the two treatment groups there was no difference in preoperative hemodynamic parameters, number...
journal_title：Herz
pub_type： 临床试验,杂志文章
doi：
更新日期：1985-12-01 00:00:00
abstract：:Atrial fibrillation is by far the most common cardiac arrhythmia in humans. The incidence of atrial fibrillation increases with age and will increase even more in the future due to the demographic changes in the population. Therefore, this arrhythmia will have a growing clinical and socioeconomic impact. Although ther...
journal_title：Herz
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00059-017-4565-2
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Recent studies suggest that circulating progenitor cells contribute to the formation of new blood vessels in adults after tissue ischemia. The infusion of these progenitor cells was used as a therapeutic approach to increase vascularization. In several animal models, progenitor cells improved vascularization...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-002-2427-y
更新日期：2002-11-01 00:00:00
abstract：:Coronary artery anomalies are detected on approximately 1.3% of coronary angiograms. Single coronary artery anomaly (SCA) is defined as the coronary artery arising from a single coronary ostium, nourishing the entire heart. SCA anomalies are usually benign; however, serious complications such as sudden cardiac death a...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-013-3897-9
更新日期：2014-09-01 00:00:00
abstract：:It is still controversial whether the arrhythmias in acute pericarditis are of myocardial or pericardial origin. The aim of the present study was to investigate the occurrence of arrhythmias and conduction disorders in patients with acute pericarditis with no endomyocardial biopsy evidence of myocarditis (group 1: 40 ...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/pl00001990
更新日期：2000-12-01 00:00:00
abstract：:To assess the results of transluminal coronary angioplasty (TCA), 42 patients (mean age 50 years) with for coronary artery disease were investigated at rest and during exercise with the ECG (n = 40), thallium-201 myocardial scintigraphy (n = 23) and equilibrium-radionuclide ventriculography (n = 32). Each method of st...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：:The 12-lead surface electrocardiogram (ECG) is of great importance for the diagnostics of cardiac arrhythmias. For the correct and systematic analysis it has a sensitivity and specificity for the correct diagnosis of supraventricular tachycardia or ventricular tachycardia of more than 95%. Nevertheless, the assessment...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-018-4684-4
更新日期：2018-03-01 00:00:00
abstract：:The aortic valve consists of three cusps attached to the wall of the aortic root. During the cardiac cycle, the aortic root undergoes complex movements that precede and aid opening and closing of the aortic valve. The aortic valve cusps themselves form thin-walled pocket-like structures, made from specialized tissue w...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-006-2836-4
更新日期：2006-08-01 00:00:00
