Abstract：
:In ten patients with angiographically-documented coronary artery disease, stable angina pectoris and reproducible exercise-induced ST-segment depression, the extent and duration of antiischemic and antianginal effects of transdermal nitroglycerin patches delivering 10 mg/24 hours were investigated according to a double-blind, crossover, placebo-controlled protocol. Exercise testing and blood sampling for determination of nitroglycerin plasma concentrations were carried out at 2.5 and twelve hours after initial application, at 2.5, twelve and 24 hours after renewed application subsequent to a twelve-hour treatment pause as well as at 2.5 hours after application of a third patch (Figure 1). At 2.5 hours after initial application there was a reduction in exercise-induced ST-segment depression from 2.7 mm +/- 0.19 (SEM) to 0.75 +/- 0.2 (-72%; p less than 0.001) (Figure 2). The exercise capacity to onset of 1 mm ST-segment depression increased from 117 Watt X min +/- 34 (SEM) to 361 Watt X min +/- 84 (+210%; p less than 0.001) (Figure 3). At twelve hours, exercise-induced ST-segment depression was reduced only from 2.5 mm +/- 13 to 1.77 +/- 0.2 (-32%; p less than 0.01) and the increase in exercise capacity to onset of 1 mm ST-segment depression was narrowed from 136 Watt X min +/- 28.5 to 215 Watt X min +/- 43 (+59%; p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Herzjournal_title
Herzauthors
Reiniger G,Menke G,Boertz A,Kraus F,Rudolph Wsubject
Has Abstractpub_date
1987-02-01 00:00:00pages
68-73issue
1eissn
0340-9937issn
1615-6692journal_volume
12pub_type
临床试验,杂志文章相关文献
HERZ文献大全abstract：:Obstructive pulmonary vascular disease and pulmonary hypertension are facts daily encountered by pediatric cardiologists. However longterm thromboembolism, pulmonary vascular obstruction and cor pulmonale are rare conditions in children. The case report of a four years old child treated by a Pudenz ventriculo venous s...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1978-04-01 00:00:00
abstract：:Radiofrequency catheter ablation has established as the first line therapy for the curative treatment of patients with accessory pathway. Atrioventricular accessory pathways irrespective of the exact localisation can be successfully ablated in more than 90% of all cases. Severe complications associated with the ablati...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/BF03044318
更新日期：1998-06-01 00:00:00
abstract：:The diagnosis of varicose veins is based on historical details pertaining to risk factors such as familial preponderance, advanced age, overweight, multiple births, professional activities carried out mainly in the standing or sitting position, use of oral contraceptives, diuretics or drugs which lower venous tone. Sw...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1989-10-01 00:00:00
abstract：OBJECTS:To show all cardiac evaluations multislice computed tomography (MSCT) can perform. METHODS:MSCTs were performed on an MSCT scanner (Mx8000; Philips Medical Systems) with enhanced contrast acquisition. The reconstructed images were sent to a workstation for multiplanar reconstruction, volume rendering, and 3-D ...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-003-2443-6
更新日期：2003-02-01 00:00:00
abstract：:While there is generell agreement that patients with aortic stenosis (AS) who have already developed symptoms, such as exertional dyspnea, angina or dizziness and syncope, require urgent surgery because of their otherwise very poor outcome, the management of asymptomatic severe AS remains controversial. Although preve...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-006-2871-1
更新日期：2006-10-01 00:00:00
abstract：:The discovery of an intracardial mass in patients presents a serious diagnostic dilemma. The differential diagnosis of this condition may seem abundant, but myxomas and intracardial thrombosis are the most frequent diagnoses. A connection between pregnancy and the presence of thrombosis has been documented frequently....
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-008-3127-z
更新日期：2008-11-01 00:00:00
abstract：:Cardiac function, including the heart muscle and valves, can be severely altered by congenital and acquired heart diseases. Several graft materials are currently used to replace diseased cardiac tissue and valvular segments. Implantable grafts are either non-vital or can trigger an immune response which leads to graft...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-010-3355-x
更新日期：2010-08-01 00:00:00
abstract：:The incidence of coronary heart disease and myocardial infarction fell gradually during the seventies. Reasons for this decline are not well understood. Speculations include changes of life style and health care. However, cardiovascular disease is still the leader of mortality in Western developed countries. Mortality...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1993-12-01 00:00:00
abstract：:47 patients with aortic valve disease were studied by left ventricular micromanometry and cineangiography before and 18 months after successful valve replacement. There were 27 patients (17 with aortic stenosis, ten with aortic insufficiency) with moderate hypertrophy (angiographic mass less than 180 g/m2) and 20 pati...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：:Non-invasive tomographic imaging modalities have recently contributed to identifying aortic intramural hematoma, a variant form of classic dissection, which is characterized by the absence of an intimal tear and thus the absence of direct flow communication, and which represents an important disease entity in acute ao...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-011-3501-0
更新日期：2011-09-01 00:00:00
abstract：:Our own previous studies of the composition of the extracellular matrix of human failing hearts showed that collagen VI seems to play a major role in the origin of cardiac fibrosis. Therefore, collagen VI was investigated in more detail in tissue samples taken from clinically normal left ventricle and from myocardium ...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：:Therapy of sudden cardiac death is dominated by the implantable cardioverter defibrillator (ICD), which is highly efficient, but also has side effects. Therefore, the adequate selection of patients who could benefit from this therapy is crucial. For risk stratification, left ventricular ejection fraction is basically ...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-009-3290-x
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:Short-term prognosis of patients with chest pain and angiographically smooth coronary arteries is good in terms of development of coronary events (fatal or nonfatal myocardial infarction, coronary death, new coronary heart disease), but long-term studies are rare. PATIENTS AND METHODS:185 consecutive patien...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-003-2295-0
更新日期：2003-08-01 00:00:00
abstract：:Following surgical correction of chronic aortic regurgitation, left ventricular (LV) volume falls to normal or near normal in most patients; this change generally occurs within the first week after surgery. During the ensuing six months, a significant regression of LV hypertrophy occurs, but most patients do not achie...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1981-06-01 00:00:00
abstract：BACKGROUND:Galectin-3 has been reported as a mediator of heart failure (HF) development and progression. Most studies, however, have been conducted on patients with chronic HF rather than acute HF (AHF). The aim of this study was to confirm galectin-3 as a prognostic marker in subjects with AHF and to investigate its p...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-017-4538-5
更新日期：2018-03-01 00:00:00
abstract：:Coronary stent implantation is currently performed in > 80% of percutaneous coronary interventions. Its main late complication is the development of in-stent restenosis (ISR), occurring in 10-80% of lesions treated in daily practice. The classification by Mehran et al. is most commonly used. Current therapeutic option...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-004-2574-4
更新日期：2004-03-01 00:00:00
abstract：:Unexplained sudden death in the young is cardiovascular in most cases. Structural and conduction defects in cardiac-related genes can conspire to underlie sudden cardiac death. Here we report a clinical investigation and an extensive genetic assessment of a Tunisian family with sudden cardiac death in young members. I...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-019-04883-1
更新日期：2020-01-22 00:00:00
abstract：BACKGROUND:Atrial remodeling in the form of fibrosis is considered the basis in the development of atrial fibrillation (AF). The aim of this study was to investigate the effects of doxycycline on atrial remodeling induced by chronic intermittent hypoxia (CIH) and the mechanisms underlying such changes. METHODS:A total...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-018-4768-1
更新日期：2020-11-01 00:00:00
abstract：:One of the most important treatment principles in interventional cardiology relies on myocardial revascularization by percutaneous coronary intervention (PCI) or surgical placement of coronary artery bypass grafts (CABG). However, in order to apply these principles effectively, it is important to identify patients who...
journal_title：Herz
pub_type： 杂志文章,实务指引
doi：10.1007/s00059-014-4180-4
更新日期：2014-12-01 00:00:00
abstract：:In congestive heart failure (CHF), even today, pharmacotherapy renders primarily only symptomatic improvement. The success of the treatment is basically dependent on the degree of functional myocardial impairment, that is, the condition of the inadequately treatable underlying disease. Treatment should be differential...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1990-06-01 00:00:00
abstract：:Despite all advances in the diagnostic and therapy of cardiovascular diseases the mortality from malignant ventricular tachyarrhythmias is still a major health problem. In addition to established therapeutic strategies in the prevention of sudden cardiac death such as antiarrhythmic drug treatment, catheter ablation o...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1994-10-01 00:00:00
abstract：:Atrial fibrillation (AF) is currently one of the major causes of ischemic stroke with an estimated stroke risk of 5% per year. Oral anticoagulation is an effective treatment for the reduction of stroke risk in patients with AF but is also associated with an increased risk of bleeding. In patients with AF it has been s...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-014-4198-7
更新日期：2015-02-01 00:00:00
abstract：:Cardiac contractility modulation (CCM) is a device therapy for patients with systolic heart failure. CCM therapy applies non-excitatory signals during the absolute refractory period of the heart cycle. It influences myocardial contractility by modulating the regulation of calcium cycling. CCM therapy has been proven t...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-011-3510-z
更新日期：2011-10-01 00:00:00
abstract：:The prevalence of overweight and obesity in children and adolescents is increasing. In Germany, 10-20% of children and youth are overweight and obese. Childhood obesity is associated with cardiovascular and other comorbidities. 25% suffer from arterial hypertension and/or hypercholesterolemia, 1% from diabetes mellitu...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-006-2860-4
更新日期：2006-09-01 00:00:00
abstract：:With increasing age valvular heart disease is among the most frequent diseases of the heart. Relevant valvular disease impairs not only the long-term prognosis but also physical resilience, activities of daily living and the quality of life. In cases of middle to high-grade symptomatic cardiac defects, valve replaceme...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-020-04915-1
更新日期：2020-04-20 00:00:00
abstract：:Despite the almost complete disappearance of the so called "postperfusion lung syndrome" after cardiac surgery with extracorporeal circulation (ECC), there is still a need for respiratory treatment in some cases, primarily for cardio-circulatory or respiratory reasons. In addition postoperative artificial ventilation ...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1978-06-01 00:00:00
abstract：:The 12-lead surface electrocardiogram (ECG) is of great importance for the diagnostics of cardiac arrhythmias. For the correct and systematic analysis it has a sensitivity and specificity for the correct diagnosis of supraventricular tachycardia or ventricular tachycardia of more than 95%. Nevertheless, the assessment...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-018-4684-4
更新日期：2018-03-01 00:00:00
abstract：:This review summarizes the present knowledge concerning the hemodynamic and myocardial effects of various pacing modalities with special reference to the importance of heart rate variability and atrioventricular synchronization. An adequate increase in heart rate, irrespective of atrioventricular synchronization, seem...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1991-06-01 00:00:00
abstract：:The genetic information for the development of an organism is stored and inherited by deoxyribonucleic acid (DNA). In higher organisms the DNA is located within the cell nucleus. DNA has the structure of a double helix and contains a specific sequence of four types of nucleotides that are specified by the bases adenin...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1993-08-01 00:00:00
abstract：BACKGROUND:Upon coincubation with platelet aggregates, CD34(+) progenitor cells have the potential to differentiate into foam cells. There is evidence that progenitor cells from diabetic and nondiabetic patients have different properties, which may affect the patients' prognosis. In this study we investigated an in vit...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-013-4012-y
更新日期：2015-05-01 00:00:00
