An overview of nucleic acids and gene regulation.

Abstract:

:The genetic information for the development of an organism is stored and inherited by deoxyribonucleic acid (DNA). In higher organisms the DNA is located within the cell nucleus. DNA has the structure of a double helix and contains a specific sequence of four types of nucleotides that are specified by the bases adenine, guanine, cytosine and thymine. Replication of the DNA double helix by DNA polymerase results in the formation of two double helices with identical nucleotide sequences. Expression of the information contained in the DNA requires the synthesis of ribonucleic acid (RNA) copies and subsequent transport of the RNA from the nucleus to the cytoplasm. One type of RNA, called messenger RNA (mRNA), contains the instruction for the amino acid sequence of polypeptides. The translation of the nucleotide sequence of mRNA into the amino acid sequence of polypeptides is facilitated by ribosomes. For the synthesis of each of the different kinds of polypeptides a specific mRNA is expressed. The expression of the genetic information is mainly regulated by direct interactions of control elements located on DNA and RNA with certain protein factors.

journal_name

Herz

journal_title

Herz

authors

Marian AJ,Roberts R

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

203-12

issue

4

eissn

0340-9937

issn

1615-6692

journal_volume

18

pub_type

杂志文章,评审

相关文献

HERZ文献大全
  • [Prognostic value of stress echocardiography].

    abstract::Appraisal of the risk to which outpatients with chest pain are exposed is an important clinical problem that frequently occurs. The need to decide in day-to-day practice between a conservative or invasive approach in patients with chest pain is often difficult and the decision has grave implications. Stress echocardio...

    journal_title:Herz

    pub_type: 杂志文章,评审

    doi:10.1007/s00059-005-2688-3

    authors: Leischik R,Erbel R

    更新日期:2005-12-01 00:00:00

  • Exercise hypertension: its measurement and evaluation.

    abstract::Blood pressure, the central parameter in the diagnosis of arterial hypertension, is subject to a high degree of variability. The dilemma for the evaluating physician is that he has no true value for the resting blood pressure that is both comparable and reproducible. Reproducibility, however, is an essential requireme...

    journal_title:Herz

    pub_type: 杂志文章

    doi:

    authors: Franz IW

    更新日期:1987-04-01 00:00:00

  • [Spontaneous dissection of the coronary arteries: a rare cardiologic diagnosis].

    abstract::A 55-year-old woman who was admitted to hospital with acute chest pain as a case of emergency suffered from an acute anteroseptal myocardial infarction. Four weeks later coronary angiography revealed a long dissection of the left anterior descending artery (LAD) as well as a significant stenosis of the left main and t...

    journal_title:Herz

    pub_type: 杂志文章

    doi:10.1007/BF03043931

    authors: Lemke P,Schwab M,Urbanyi B,Hellberg K

    更新日期:1999-08-01 00:00:00

  • [Coronary artery bypass surgery for the treatment of acute coronary syndromes].

    abstract::According to the current guidelines coronary revascularization in acute coronary syndromes (ACS) is primarily performed by percutaneous coronary interventions (PCI). However, in several scenarios like complex coronary pathologies, unsuccessful PCI, complicated PCI or cardiogenic shock, surgical coronary revascularizat...

    journal_title:Herz

    pub_type: 杂志文章,评审

    doi:10.1007/s00059-010-3327-1

    authors: Rastan AJ,Thiele H,Schuler G,Mohr FW

    更新日期:2010-03-01 00:00:00

  • Recurrent takotsubo cardiomyopathy : variable pattern of ventricular involvement.

    abstract:BACKGROUND:Takotsubo cardiomyopathy (TTC) is a transient left ventricular (LV) dysfunction that predominantly affects older women and has three main variants: apical, mid-ventricular, and basal. The recurrence rate of TTC is roughly around 11 % at 4-year follow-up. The pathogenesis of TTC is not clear and various theor...

    journal_title:Herz

    pub_type: 杂志文章

    doi:10.1007/s00059-013-3896-x

    authors: Singh K,Parsaik A,Singh B

    更新日期:2014-12-01 00:00:00

  • Comparison of procedural success between two radial sheaths : Comparison of the 6-Fr Glidesheath Slender to 6-Fr standard sheath.

    abstract:BACKGROUND:The most common cause of procedural failure in cardiac catheterization using the transradial approach is radial artery spasm. The aim of this study was to compare the procedural success rate of the 6‑Fr Glidesheath Slender with the 6‑Fr standard sheath in transradial coronary angiography and intervention. M...

    journal_title:Herz

    pub_type: 杂志文章

    doi:10.1007/s00059-018-4707-1

    authors: Gul B,Stolar M,Stair B,Hermany P,Willis S,Mena-Hurtado C,Attaran R

    更新日期:2020-02-01 00:00:00

  • The role of fQRS in coronary artery disease. A meta-analysis of observational studies.

    abstract:BACKGROUND:Experimental and clinical studies have suggested that the presence of fragmented QRS complex (fQRS) is associated with various cardiovascular diseases. fQRS may predict major adverse cardiovascular events (MACE). The current meta-analysis was performed using clinical outcome studies to evaluate the role of f...

    journal_title:Herz

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00059-014-4155-5

    authors: Xu Y,Qiu Z,Xu Y,Bao H,Gao S,Cheng X

    更新日期:2015-03-01 00:00:00

  • Midventricular obstruction and clinical decision-making in obstructive hypertrophic cardiomyopathy.

    abstract::The presence of intraventricular obstruction is a powerful predictor of outcome in patients with hypertrophic cardiomyopathy (HCM) and, when associated with severe, drug-refractory symptoms, should be managed aggressively. Resting left ventricular outflow obstruction is found in approximately 20% of the patients, clas...

    journal_title:Herz

    pub_type: 杂志文章,评审

    doi:10.1007/s00059-006-2928-1

    authors: Cecchi F,Olivotto I,Nistri S,Antoniucci D,Yacoub MH

    更新日期:2006-12-01 00:00:00

  • Postcardiac injury syndrome after cardiac implantable electronic device implantation.

    abstract:BACKGROUND:Postcardiac injury syndrome (PCIS) is an inflammatory complication that derives from injury to the epicardium, myocardium, or endocardium. It occurs after trauma, myocardial infarction, percutaneous coronary intervention, cardiac surgery, intracardiac ablation, and implantation of cardiac implantable electro...

    journal_title:Herz

    pub_type: 杂志文章

    doi:10.1007/s00059-020-04910-6

    authors: Filbey K,Sedaghat-Hamedani F,Kayvanpour E,Xynogalos P,Scherer D,Meder B,Katus HA,Zitron E

    更新日期:2020-11-01 00:00:00

  • [Myocardial revascularization].

    abstract::Coronary artery disease (CAD) is a leading cause of morbidity and mortality in western countries and is of significant socio-economic importance due to its increasing prevalence. Until percutaneous coronary interventions (PCI) were established, CAD could only be treated by surgical revascularization or pharmacological...

    journal_title:Herz

    pub_type: 杂志文章

    doi:10.1007/s00059-013-3917-9

    authors: Möllmann H,Szardien S,Kempfert J,Nef H,Liebetrau C,Walther T,Hamm C

    更新日期:2013-08-01 00:00:00

  • [Pathogenesis and laboratory diagnosis of venous thrombosis].

    abstract:UNLABELLED:Due to the increasing number of elderly as well as chronically-ill patients, venous thrombosis assumes an increasing role as a typical complication of many courses of disease. Postoperatively, in patients without anticoagulation, fibrinogen tests show venous thrombosis in the lower extremities in up to 50% b...

    journal_title:Herz

    pub_type: 杂志文章,评审

    doi:

    authors: Schramm W,Spannagl M

    更新日期:1989-12-01 00:00:00

  • Use of tolvaptan vs. furosemide in older patients with heart failure : Meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:It is not known whether older patients with acute heart failure (HF) receiving tolvaptan have decreased mortality rates and a better long-term prognosis than patients who receive furosemide. We conducted a systematic review of randomized controlled trials (RCTs) to address this issue. METHODS:The Medline, E...

    journal_title:Herz

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00059-017-4563-4

    authors: Huang WL,Yang Y,Yang J,Yang J,Wang HB,Xiong XL,Zhang YF

    更新日期:2018-06-01 00:00:00

  • [Treatment of acute heart failure].

    abstract::Acute heart failure is a symptom complex of heterogeneous etiology. Clinically, it comprises a broad spectrum ranging from hypertensive pulmonary edema in patients with preserved left ventricular systolic function up to cardiogenic shock in patients with severely depressed left ventricular function. The pathophysiolog...

    journal_title:Herz

    pub_type: 杂志文章

    doi:10.1007/s00059-015-4336-x

    authors: Simonis G,Spitzer SG,Stumpf J,Dörr R

    更新日期:2015-08-01 00:00:00

  • Biomarkers for infarct diagnosis and rapid rule-out/rule-in of acute myocardial infarction.

    abstract::The 4th edition of the Universal Definition of Myocardial Infarction (MI) recommends measurement of cardiac troponin (cTn) T or I for the diagnosis of MI due to their absolute cardiac tissue specificity. In this MI definition, values exceeding the 99th percentile of a healthy reference population distinguish between d...

    journal_title:Herz

    pub_type: 杂志文章,评审

    doi:10.1007/s00059-020-04943-x

    authors: Giannitsis E,Gopi V

    更新日期:2020-09-01 00:00:00

  • [Surgical treatment of aortic valve stenosis].

    abstract::Surgical aortic valve replacement still represents the gold standard in patients with severe symptomatic aortic valve stenosis. In addition to conventional aortic valve replacement by mechanical or biological prostheses via a median sternotomy, novel approaches including minimally invasive strategies and new devices, ...

    journal_title:Herz

    pub_type: 杂志文章,评审

    doi:10.1007/s00059-017-4593-y

    authors: Liakopoulos OJ,Merkle J,Wahlers T,Choi YH

    更新日期:2017-09-01 00:00:00

  • [Morphology and function of the intrinsic cardiac nervous system].

    abstract::Access to the intrinsic cardiac autonomic nervous system can now be achieved via percutaneous catheter stimulation techniques. Thereby, cardiac functions like atrioventricular nodal conduction, sinus cycle length and ventricular inotropy can be dynamically regulated. The present article provides examples of this new t...

    journal_title:Herz

    pub_type: 杂志文章

    doi:10.1007/s00059-006-2781-2

    authors: Schauerte P,Schimpf T,Mischke K,Zarse M,Schmid M,Plisiene J,Maurath P,Kelm M,Pauza DH

    更新日期:2006-04-01 00:00:00

  • [Plasma catecholamines and hemodynamics in patients with heart failure (author's transl)].

    abstract::Plasma catecholamines and hemodynamic were assessed in 32 patients with heart failure of varying degrees due to coronary artery disease as well as in twelve healthy control subjects. The studies employed the use of a (Swan-Ganz) semi-floating, balloon-tipped, thermodilution catheter during supine bicycle ergometry at ...

    journal_title:Herz

    pub_type: 杂志文章

    doi:

    authors: Lehmann M,Keul J,Dickhuth HH

    更新日期:1982-06-01 00:00:00

  • [Arteriosclerosis as a sequela of chronic Chlamydia pneumoniae infection].

    abstract::In the last years several new data allow a controversial but convincing interpretation of the pathogenesis of atherosclerosis (arteriosclerosis). Atherosclerosis can be apparently the result of ultrachronic persistent infection by Chlamydia pneumoniae and not the result of different risk factors. The main arguments fo...

    journal_title:Herz

    pub_type: 杂志文章,评审

    doi:10.1007/BF03044604

    authors: Stille W,Dittmann R

    更新日期:1998-05-01 00:00:00

  • [Heart failure and anemia].

    abstract::Chronic heart failure has an age-dependent prevalence of 2% and is therefore one of the most frequent diseases in western societies. A reduced hemoglobin concentration according to the definition of the World Health Organization is a common comorbidity affecting more than half of all heart failure patients. Elderly pa...

    journal_title:Herz

    pub_type: 杂志文章

    doi:10.1007/s00059-013-3901-4

    authors: Reda S,Motloch LJ,Hoppe UC

    更新日期:2013-09-01 00:00:00

  • [Alcoholism as an illness].

    abstract::Formerly the term alcoholism has been defined only by alcohol-related conditions. About 20 years ago a WHO committee recommended to differentiate between alcohol abuse and alcohol dependence. The new classifications and manuals followed this proposal: Criteria for alcohol abuse are still alcohol sequelae whereas alcoh...

    journal_title:Herz

    pub_type: 杂志文章,评审

    doi:

    authors: Feuerlein W

    更新日期:1996-08-01 00:00:00

  • Hemodynamics and exercise capacity during pacemaker stimulation.

    abstract::This review summarizes the present knowledge concerning the hemodynamic and myocardial effects of various pacing modalities with special reference to the importance of heart rate variability and atrioventricular synchronization. An adequate increase in heart rate, irrespective of atrioventricular synchronization, seem...

    journal_title:Herz

    pub_type: 杂志文章,评审

    doi:

    authors: Nordlander R,Hedman A

    更新日期:1991-06-01 00:00:00

  • Molecular mechanisms of inherited ventricular arrhythmias.

    abstract:BACKGROUND:Inherited ventricular arrhythmias such as the long QT syndrome (LQTS), Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia (CPVT), idiopathic ventricular fibrillation (VF), and arrhythmogenic right ventricular cardiomyopathy (ARVC) account for a relevant proportion of sudden cardiac death...

    journal_title:Herz

    pub_type: 杂志文章,评审

    doi:10.1007/s00059-002-2436-x

    authors: Wichter T,Schulze-Bahr E,Eckardt L,Paul M,Levkau B,Meyborg M,Schäfers M,Haverkamp W,Breithardt G

    更新日期:2002-12-01 00:00:00

  • [Treatment of acute ST Elevation myocardial infarction in a regional network ("Drip & Ship Network Rostock")].

    abstract::Management of acute ST elevation myocardial infarction (STEMI) demands rapid and complete reperfusion of the infarct-related artery (IRA). With postinfarction prognosis depending on time delay from onset of symptoms to complete reperfusion (TIMI 3 flow) of the IRA, primary percutaneous coronary intervention (PPCI) per...

    journal_title:Herz

    pub_type: 杂志文章,评审

    doi:10.1007/s00059-007-3061-5

    authors: Schneider H,Ince H,Rehders T,Körber T,Weber F,Kische S,Chatterjee T,Nienaber CA,Drip&Ship-Netzwerk (District of Rostock Infarct Project & Shipping Patients).

    更新日期:2007-12-01 00:00:00

  • Morphologic observations in coronary arteries, aortocoronary saphenous vein bypass grafts and infant aortae following balloon angioplasty procedures.

    abstract::Morphologic observations following balloon angioplasty are summarized from adult patients undergoing coronary or saphenous vein bypass graft angioplasty and from infants undergoing aortic valve stenosis angioplasty. Possible mechanisms of dilation injury and complications of angioplasty balloon bursting are reviewed. ...

    journal_title:Herz

    pub_type: 杂志文章

    doi:

    authors: Waller BF

    更新日期:1985-10-01 00:00:00

  • Anticoagulation and atrial fibrillation.

    abstract::The decision to anticoagulate patients with atrial fibrillation (AF) involves weighting the risk of an embolic event without therapy versus the risk of a hemorrhagic event on therapy. Improved methods of monitoring anticoagulation with the International Normalized Ratio (INR), and recent evidence of the efficacy and s...

    journal_title:Herz

    pub_type: 杂志文章,评审

    doi:

    authors: Atwood JE,Albers GW

    更新日期:1993-02-01 00:00:00

  • Converting-enzyme inhibitor therapy for chronic heart failure.

    abstract::In congestive heart failure, acute administration of the converting enzyme inhibitor captopril leads to a decrease in arterial pressure, systemic vascular resistance, left ventricular filling pressure, and the end-diastolic volumes of both ventricles, as well as to an increase in cardiac index, stroke volume index, ri...

    journal_title:Herz

    pub_type: 杂志文章

    doi:

    authors: Massie BM,Kramer BL,Topic N

    更新日期:1983-04-01 00:00:00

  • Interventional and intravascular MR angiography.

    abstract::Magnetic resonance imaging (MRI) has a number of characteristics which make it attractive for guidance of intravascular therapeutic procedures, including high soft tissue contrast, imaging in any arbitrary oblique plane, lack of ionizing radiation, and the ability to provide functional information, such as flow veloci...

    journal_title:Herz

    pub_type: 杂志文章,评审

    doi:10.1007/s000590050036

    authors: Ladd ME,Debatin JF

    更新日期:2000-06-01 00:00:00

  • Big endothelin-1 as a predictor of atrial fibrillation recurrence after primary ablation only in patients with paroxysmal atrial fibrillation.

    abstract:BACKGROUND:Atrial fibrillation (AF) recurrence after ablation is difficult to predict. The development of AF is associated with inflammation, and inflammatory markers such as big endothelin-1 (big ET-1) reflect inflammatory status. It is unknown, however, whether big ET-1 can be used as a predictor for AF recurrence. T...

    journal_title:Herz

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00059-012-3626-9

    authors: Wang H,Liu J,Fang P,Lei S,Li X,Hou Y,Zhang S

    更新日期:2012-12-01 00:00:00

  • Remodelling and adverse remodelling in CAD.

    abstract::Remodelling is the adaptive or maladaptive response to cardiac overload or injury resulting in changes of size and function of the heart. The final pathway of maladaptive or adverse cardiac remodelling is the evolution of heart failure or sudden cardiac death. In coronary artery disease, ischemic injury leads to chang...

    journal_title:Herz

    pub_type: 杂志文章

    doi:10.1007/s00059-012-3660-7

    authors: Brenner S,Ertl G

    更新日期:2012-09-01 00:00:00

  • [Progression of coronary calcium].

    abstract:BACKGROUND:The progression of coronary atherosclerosis is determined by risk factor exposure. It is also an important predictor of future cardiac events in its own right. Coronary calcium represents an integral part of coronary atherosclerosis. Accurate measurements can be obtained by using electron-beam computed tomog...

    journal_title:Herz

    pub_type: 杂志文章,评审

    doi:10.1007/pl00002031

    authors: Schmermund A

    更新日期:2001-06-01 00:00:00