Abstract：
:In a prospective double-blind study of 40 male patients requiring aorto-coronary bypass surgery, a dose of 8 ng/kg/min of PGI2 was infused throughout extracorporeal circulation (ECC) (control group: glycine buffer). Between the two treatment groups there was no difference in preoperative hemodynamic parameters, number of preoperative infarctions, or number of implantated aorto-coronary vein grafts. Before, during and up to one day after ECC, extensive hemodynamic and hemostaseologic examinations were performed repeatedly (a total of twelve times in each patient). During ECC and due to inhibition of platelet function, platelet counts were significantly higher in the PGI2-treated group without clinical evidence for an increased bleeding tendency. Systemic blood pressure, heart rate and perfusion pressure did not differ significantly in the two treatment groups (with the exception of one control 60 minutes after onset of ECC). Peri- and postoperative function of the kidneys and lung also demonstrated similar results in both treatment groups. The platelet preserving effect of PGI2 correlated with a significant decrease of severe arrhythmias (tachyarrhythmias before termination of extracorporeal circulation) and a reduction in mechanical reperfusion. It is suggested that PGI2 exerts its beneficial effect on the myocardium by inhibiting platelet aggregation and/or by an antiarrhythmic effect on the myocardium. Whether the antiarrhythmic effect of PGI2 on the myocardium is indirect (reduction of microcirculatory disorders produced by inhibition of platelet aggregation) or direct (electrical stabilization of the myocardial cell membrane), is the subject of further investigations.
journal_name
Herzjournal_title
Herzauthors
Heinrich D,Wagner WL,Höge Rsubject
Has Abstractpub_date
1985-12-01 00:00:00pages
357-65issue
6eissn
0340-9937issn
1615-6692journal_volume
10pub_type
临床试验,杂志文章相关文献
HERZ文献大全abstract：:Certification is a critical component of quality assurance in medicine. From the certification of individual persons, through units and up to whole hospitals, certification stimulates testing and optimization of treatment processes, thereby improving the quality of care. Minimum case numbers needed to acquire a certif...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-018-4718-y
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND AND PURPOSE:In experimental arterial hypertension, left ventricular hypertrophy (LVH) becomes pathologic with impaired myocardial function if myocardial fibrosis occurs. Myocardial fibrosis is associated with activated circulating or local renin-angiotensin-aldosterone systems. The primary objective of this ...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-003-2524-6
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:Inherited ventricular arrhythmias such as the long QT syndrome (LQTS), Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia (CPVT), idiopathic ventricular fibrillation (VF), and arrhythmogenic right ventricular cardiomyopathy (ARVC) account for a relevant proportion of sudden cardiac death...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-002-2436-x
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:Upon coincubation with platelet aggregates, CD34(+) progenitor cells have the potential to differentiate into foam cells. There is evidence that progenitor cells from diabetic and nondiabetic patients have different properties, which may affect the patients' prognosis. In this study we investigated an in vit...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-013-4012-y
更新日期：2015-05-01 00:00:00
abstract：:I. The actual data base on the decision-making process of indication for revascularization reveals that angiographic severity of coronary artery disease (CAD) is the primary determinant of referral to coronary interventional procedures. Several recent studies demonstrated that after an acute myocardial infarction, wom...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-005-2716-3
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND AND PURPOSE:: Drug-eluting stents (DES) have been shown to reduce the risk of in-stent stenosis, one of the major problems of percutaneous coronary intervention (PCI) with implantation of baremetal stents. DES are approved in Germany since 2002. The following study is based on data of the ALKK PCI registry a...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-008-3097-1
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:The German national guidelines on chronic heart failure provide treatment recommendations to physicians and reflect the current level of evidence; however, it is questionable to what extent these recommendations are applied in the routine practice and what the effect of guideline adherence on mortality is. ...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-016-4401-0
更新日期：2016-11-01 00:00:00
abstract：:The present data demonstrate clinical feasibility of intracoronary beta brachytherapy and fail to reveal any complications that could be attributed to it. Definitive conclusions regarding safety will have to await longer term evaluation. Proof of efficacy will require strict dose finding evaluation of higher doses tha...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/BF03043599
更新日期：1998-09-01 00:00:00
abstract：:The case presented here is intended to raise awareness of two uncommon coronary angiographic findings in the clinical context of acute coronary syndrome. The prevalence of patients presenting with spontaneous coronary dissection as the underlying cause of an ST-elevation myocardial infarction is low. It is typically f...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-011-3522-8
更新日期：2012-05-01 00:00:00
abstract：:Highly purified omega-3 polyunsaturated fatty acids (PUFAs) (Omacor) is the focus of an extensive and ambitious clinical development program that seeks to build on the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione study. Studies currently in progress inclu...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：2006-12-01 00:00:00
abstract：:Access to the intrinsic cardiac autonomic nervous system can now be achieved via percutaneous catheter stimulation techniques. Thereby, cardiac functions like atrioventricular nodal conduction, sinus cycle length and ventricular inotropy can be dynamically regulated. The present article provides examples of this new t...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-006-2781-2
更新日期：2006-04-01 00:00:00
abstract：:Hydralazine is a smooth muscle relaxant and a potent arteriolar dilator. The major hemodynamic effect of hydralazine in patients with heart failure are increased cardiac output and stroke volume, and decreased vascular resistance without any significant change in pulmonary and systemic venous pressure. Hydralazine als...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1983-08-01 00:00:00
abstract：BACKGROUND:Once contraindicated, beta-blockers have become an established, evidence-based, recommended treatment concept in chronic heart failure during the last years. PATHOPHYSIOLOGY:The increased activation of the adrenergic system in heart failure syndrome, which leads to transmission of several adverse biological...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-002-2353-z
更新日期：2002-03-01 00:00:00
abstract：:The impaired cardiac performance in patients with congestive cardiac failure may be improved by the introduction of inotropic therapy. Dopamine and dobutamine are both potent cardiac stimulants although their haemodynamic profile is different. Dobutamine would appear to be the more appropriate choice in cardiac failur...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1983-02-01 00:00:00
abstract：:Adequate skin perfusion is one of the most important prerequisites for healing of trophic lesions and amputation wounds in patients with peripheral arterial disease. The discrepancies possible between macro- and microcirculations stress the necessity of new methods for assessment of terminal vascular beds. With laser-...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1988-12-01 00:00:00
abstract：BACKGROUND:Culture-negative endocarditis is a diagnostic challenge with variable clinical presentation and protean manifestations. ETIOLOGY AND DIAGNOSIS:The two main causes why endocarditis may be culture-negative are 1. antibiotic treatment prior to obtaining blood cultures, and 2. the presence of fastidious microor...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-001-2314-y
更新日期：2001-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study was the analysis of long-term results in patients with hemodynamically significant mitral valve disease due to extensively calcified mitral annulus who underwent decalcification and patch reconstruction. PATIENTS AND METHODS:Between 1996 and 2008 a total of 109 patients underwent surger...
journal_title：Herz
pub_type： 临床试验,杂志文章
doi：10.1007/s00059-011-3576-7
更新日期：2012-11-01 00:00:00
abstract：:Left ventricular hypertrophy (LVH) is a strong, independent predictor of cardiovascular events and all-cause mortality. Patients with LVH are at increased risk for stroke, coronary heart disease, congestive heart failure, and sudden cardiac death. Hypertension is a major influence on the development of LVH. The progno...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-006-2819-5
更新日期：2006-06-01 00:00:00
abstract：:Management of acute ST elevation myocardial infarction (STEMI) demands rapid and complete reperfusion of the infarct-related artery (IRA). With postinfarction prognosis depending on time delay from onset of symptoms to complete reperfusion (TIMI 3 flow) of the IRA, primary percutaneous coronary intervention (PPCI) per...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-007-3061-5
更新日期：2007-12-01 00:00:00
abstract：:This review summarizes some information on the management of diabetic patients at risk for or with already established coronary artery disease. Improved knowledge among diabetologists regarding treatment and prevention of cardiovascular complications and among cardiologists regarding diabetology is a prerequisite for ...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-008-3105-5
更新日期：2008-04-01 00:00:00
abstract：:Obstructive pulmonary vascular disease and pulmonary hypertension are facts daily encountered by pediatric cardiologists. However longterm thromboembolism, pulmonary vascular obstruction and cor pulmonale are rare conditions in children. The case report of a four years old child treated by a Pudenz ventriculo venous s...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1978-04-01 00:00:00
abstract：:Coronary stent implantation is currently performed in > 80% of percutaneous coronary interventions. Its main late complication is the development of in-stent restenosis (ISR), occurring in 10-80% of lesions treated in daily practice. The classification by Mehran et al. is most commonly used. Current therapeutic option...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-004-2574-4
更新日期：2004-03-01 00:00:00
abstract：:Modern therapeutic options in ischemic coronary disease such as thrombolysis, coronary angioplasty, new emerging strategies in treating heart failure and secondary prevention have resulted in decreasing cardiac mortality over the last ten years. In the era of interventional cardiology a new focus of clinical interest ...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1994-02-01 00:00:00
abstract：:Numerous clinical and experimental studies have suggested that adequate pulmonary blood flow and normal central venous pressure may be maintained without significant contribution of right ventricular function. These data induced experimental and clinical research in the quest for complete bypass of the right heart. Mo...
journal_title：Herz
pub_type： 历史文章,杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:Patients with congenital heart disease have an increased chance to suffer from brady- as well as tachyarrhythmias. The impact of these on quality of life, morbidity and mortality is more often imperative as compared to heart-healthy individuals. The substrate for these may be either congenital or acquired. Improvement...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/BF03043882
更新日期：1999-06-01 00:00:00
abstract：:In this investigation, we studied the feasibility of 3D-reconstruction from 2D cross-sectional intracoronary ultrasound images. A computer-aided, automated 3D-reconstruction was used to generate cylindrical and sagittal format of vessels in vitro (n = 9) and in vivo (n = 48). Ultrasound 2D-images were acquired with a ...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：:M-mode, two-dimensional and Doppler echocardiography enable evaluation of morphologic changes in valvular structures, detection of secondary changes in cardiac chambers and left ventricular function and quantification of blood flow patterns. In mitral stenosis, with M-mode echocardiography the diagnosis can be establi...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：:Henoch-Schönlein purpura (HSP) is characterized by vasculitic involvement of small-sized vessels and results in multisystem manifestations. Cardiac involvement is extremely rare and myocardial infarction with coronary thrombus formation in those patients has also rarely been reported. Herein, we report a 33-year-old m...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-012-3597-x
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:In Germany, about 6,000 pregnancies in women with grown-up congenital heart disease or acquired valvular lesions are expected per year. The pregnancy-related physiology is characterized by a 50% increase in plasma volume and a 25% increase in erythrocyte volume. The cardiac output increases by 40% due to 30%...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-003-2467-y
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:Galectin-3 has been reported as a mediator of heart failure (HF) development and progression. Most studies, however, have been conducted on patients with chronic HF rather than acute HF (AHF). The aim of this study was to confirm galectin-3 as a prognostic marker in subjects with AHF and to investigate its p...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-017-4538-5
更新日期：2018-03-01 00:00:00
