Abstract:
:During the past 30 years, thousands of quantitative structure-activity relationships (QSAR) have been published for all sorts of chemicals acting on many forms of life or parts thereof (DNA, enzymes, organelles, etc.). Very little effort has been made to show the relationship among these equations. In this report, we discuss two examples, the toxicity of phenols to rats and the effect of aniline mustards on a variety of living systems, where the electronic effects in the QSAR can be correlated to QSAR from physical organic chemistry. This enables one to make better mechanistic deductions about the biological structure-activity relationships. From this, it is concluded that radicals formed from the phenols cause birth defects.
journal_name
Crit Rev Toxicoljournal_title
Critical reviews in toxicologyauthors
Hansch C,Telzer BR,Zhang Ldoi
10.3109/10408449509089887subject
Has Abstractpub_date
1995-01-01 00:00:00pages
67-89issue
1eissn
1040-8444issn
1547-6898journal_volume
25pub_type
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