Abstract：
:Heat-induced total body hyperthermia has been shown to synergistically enhance the in vivo antitumor effects of MuIFN-gamma directed against B16 melanoma in mice. This observation was made with an 8-hour exposure to hyperthermia that was administered following MuIFN-gamma treatment. It was not known whether this was the most efficacious treatment protocol. Various treatment protocols exploring MuIFN-gamma treatment at different relative times of exposure to hyperthermia and involving different durations of hyperthermia were evaluated. In a 5-day course of therapy, B16 tumor-bearing mice were injected with MuIFN-gamma or mock interferon and incubated in a dry incubator (resulting in a 2 degrees C rise in body temperature). The antitumor efficacy of MuIFN-gamma administered before, in the middle of, or following 8 hours of hyperthermia was evaluated. The antitumor effects of MuIFN-gamma were synergistically enhanced when the MuIFN-gamma was administered before 8 hours of hyperthermia (3.9-fold greater increased life span than with MuIFN-gamma treatment alone). However, when MuIFN-gamma was administered in the middle or following hyperthermia, the life spans were essentially the same as for MuIFN-gamma treatment alone, indicating that the effect of the hyperthermia exposures according to these treatment protocols were less than additive. Administration of MuIFN-gamma before hyperthermia exposures of 2 hours, 5 hours, and 8 hours showed antagonistic, additive, and synergistic interactions of the MuIFN-gamma treatment and hyperthermia exposure, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Biol Regul Homeost Agentsjournal_title
Journal of biological regulators and homeostatic agentsauthors
Fleischmann WR Jr,Fleischmann CMsubject
Has Abstractpub_date
1994-10-01 00:00:00pages
101-7issue
4eissn
0393-974Xissn
1724-6083journal_volume
8pub_type
杂志文章abstract：:With the development of photoelectric technology and single-chip microcomputer technology, objective optometry, also known as automatic optometry, is becoming precise. This paper proposed a presbyopia optometry method based on diopter regulation and Charge Couple Device (CCD) imaging technology and, in the meantime, d...
journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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更新日期：2014-10-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
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journal_title：Journal of biological regulators and homeostatic agents
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更新日期：2015-04-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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更新日期：2011-04-01 00:00:00
