Abstract：
:Microscopic satellites (microsatellites) in primary melanoma are defined as one or more discontinuous nests of neoplastic melanocytes measuring more than 0.05 mm in diameter that are clearly separated by normal dermis (i.e., no fibrosis or inflammation) from the main invasive component of the melanoma by a distance of at least 0.3 mm. Long considered an adverse prognostic variable, there has been debate about whether these satellites in fact represent lymphovascular invasion. In this preliminary study, 6 cases of primary cutaneous melanoma containing microsatellites were stained immunohistochemically for endothelial cells, using the markers CD31 and D2-40 (podoplanin, a marker of lymphatic endothelium). In none of the cases was positive staining found to surround the tumor deposits. In one case that also showed independent lymphovascular and perineural invasion, a small CD31 positive vessel within the microsatellite was found to contain tumor cells. The possible significance of these findings is discussed.
journal_name
J Biol Regul Homeost Agentsjournal_title
Journal of biological regulators and homeostatic agentsauthors
Kaley J,Patterson JW,Chokoeva AA,Lotti T,Wollina U,Tchernev Gsubject
Has Abstractpub_date
2015-01-01 00:00:00pages
65-8issue
1 Suppleissn
0393-974Xissn
1724-6083pii
15journal_volume
29pub_type
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 社论
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2017-04-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
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journal_title：Journal of biological regulators and homeostatic agents
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doi：
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2015-04-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
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journal_title：Journal of biological regulators and homeostatic agents
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doi：
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 社论,评审
doi：
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2015-07-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,评审
doi：
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
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更新日期：2018-09-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 临床试验,信件
doi：
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