Abstract：
:Dental pulp stem cells (DPSCs) are multipotent stem cells with the potential to differentiate into various cell types. For this reason, they have been proposed as an alternative source for mesenchymal stem cells. Somatostatin is a peptide hormone with an inhibitory effect on several endogenous hormones. The aim of our study is to investigate whether somatostatin can promote or inhibit differentiation of DPSCs in osteoblasts and bone tissue. DPSCs were extracted from third molars of healthy subjects, and were treated with somatostatin at the concentration of 100 ng/ml for 24 and 48 h. Gene expression in treated DPSCs was compared with untreated cells (control) in order to check the effect of somatostatin on stem cell differentiation. After 24 h of treatment many genes investigated were down-regulated in treated DPSCs vs untreated DPSCs. Significantly up-regulated gene (Fold change > 2) was the Bone Morphogenetic Protein BMP4. On the contrary somatostatin induced the over-expression of bone related genes after 48 h of treatment (i.e. BMPR1B and BMPR2). TGFB family genes and their receptors were also significantly up-regulated after 48 h of treatment. Somatostatin demonstrated to promote the self-renewal of DPSCs: in our experiments somatostatin mainly acted on TGFB family genes. Further studies are needed to explore this new way of creating bone tissue.
journal_name
J Biol Regul Homeost Agentsjournal_title
Journal of biological regulators and homeostatic agentsauthors
Lauritano D,Avantaggiato A,Candotto V,Cura F,Gaudio RM,Scapoli L,Palmieri Asubject
Has Abstractpub_date
2015-07-01 00:00:00pages
54-8issue
3 Suppl 1eissn
0393-974Xissn
1724-6083pii
12journal_volume
29pub_type
杂志文章abstract：:Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first described in a cluster of patients in Wuhan, China, in December of 2019. Over the past few months, COVID-19 has rapidly spread worldwide becoming the first pandemic of the 21st century. COVID-19 resul...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,评审
doi：
更新日期：2020-07-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
abstract：:7, 12- Dimethylbenz-(a)-anthracene (DMBA) has been used for a long time to induce rat mammary gland carcinogenesis. In a previous paper we described the effects of diet, of non-steroidal anti-inflammatory drugs and the combination of these two factors on breast cancer. We also pointed out that DMBA tumor generating pr...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2017-07-01 00:00:00
abstract：:Stem cells are a promising tool for bone tissue regeneration. Dental pulp stem cells (DPSCs) can be easily obtained even in human young adults. In this study we investigated the capability of DPSCs, to express the osteoblastic phenotype when cultured with osteogenic medium. DPSCs isolated from the dental pulp of impac...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2010-04-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
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更新日期：1991-10-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
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更新日期：2014-04-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：10.23812/19-257A
更新日期：2019-09-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2019-05-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
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更新日期：2015-01-01 00:00:00
abstract：:A successful Total Knee Arthroplasty (TKA) requires stability, but rarely in primary TKA, a prosthesis with more constraint than a posterior-stabilizer (PS) is necessary. In patients with severe varus/valgus deformities with incompetent collateral ligaments or in knees that cannot be adequately balanced after ligament...
journal_title：Journal of biological regulators and homeostatic agents
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更新日期：2017-10-01 00:00:00
abstract：:Adenoidal hypertrophy (AH) represents one of the most frequent indications for surgery in children. Recently, treatment with intranasal corticosteroids has been suggested to decrease the size of AH. The aim of the study is to evaluate the long-term effect of intranasal flunisolide on AH during a 12-month follow-up. On...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2009-04-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
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更新日期：2018-05-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
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更新日期：2013-04-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
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更新日期：2016-10-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
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更新日期：2019-03-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 社论,评审
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更新日期：2009-07-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,评审
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更新日期：2018-11-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
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更新日期：2020-07-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
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更新日期：2013-10-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
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更新日期：2016-01-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2015-07-01 00:00:00
