EFFECT OF SOMATOSTATIN ON DENTAL PULP STEM CELLS.

Abstract:

:Dental pulp stem cells (DPSCs) are multipotent stem cells with the potential to differentiate into various cell types. For this reason, they have been proposed as an alternative source for mesenchymal stem cells. Somatostatin is a peptide hormone with an inhibitory effect on several endogenous hormones. The aim of our study is to investigate whether somatostatin can promote or inhibit differentiation of DPSCs in osteoblasts and bone tissue. DPSCs were extracted from third molars of healthy subjects, and were treated with somatostatin at the concentration of 100 ng/ml for 24 and 48 h. Gene expression in treated DPSCs was compared with untreated cells (control) in order to check the effect of somatostatin on stem cell differentiation. After 24 h of treatment many genes investigated were down-regulated in treated DPSCs vs untreated DPSCs. Significantly up-regulated gene (Fold change > 2) was the Bone Morphogenetic Protein BMP4. On the contrary somatostatin induced the over-expression of bone related genes after 48 h of treatment (i.e. BMPR1B and BMPR2). TGFB family genes and their receptors were also significantly up-regulated after 48 h of treatment. Somatostatin demonstrated to promote the self-renewal of DPSCs: in our experiments somatostatin mainly acted on TGFB family genes. Further studies are needed to explore this new way of creating bone tissue.

authors

Lauritano D,Avantaggiato A,Candotto V,Cura F,Gaudio RM,Scapoli L,Palmieri A

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

54-8

issue

3 Suppl 1

eissn

0393-974X

issn

1724-6083

pii

12

journal_volume

29

pub_type

杂志文章
  • Covid-19 and cardiac involvement in childhood: state of the art.

    abstract::Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first described in a cluster of patients in Wuhan, China, in December of 2019. Over the past few months, COVID-19 has rapidly spread worldwide becoming the first pandemic of the 21st century. COVID-19 resul...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章,评审

    doi:

    authors: SPECIAL ISSUE: FOCUS ON PEDIATRIC CARDIOLOGY.,Cuppari C,Ceravolo G,Ceravolo MD,Sestito S,Nicocia G,Chimenz R,Salpietro C,Calabrò MP

    更新日期:2020-07-01 00:00:00

  • Cyclin-dependent kinase 7 is a potential therapeutic target in papillary thyroid carcinoma.

    abstract::Given the pathological incidence of metastases or radioiodine-refractory papillary thyroid carcinoma (PTC) is increasing worldwide, patients have little alternatives when choosing effective drugs. Therefore, it is necessary to develop new therapeutic targets for PTC treatment. CDK7 is a member of the cyclindependent p...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Gong Y,Yang J,Liu F,Li Z,Gong R,Wei T

    更新日期:2018-11-01 00:00:00

  • Generalized eruptive histiocytoma in adult patient.

    abstract::Generalized eruptive histiocytoma is a rare benign skin disorder with less than 50 cases reported world-wide. It belongs to type IIb of histiocytoses. The histiocytic cells are CD68 positive but lack other markers like CD1a or S100. We report on a 60-year-old male patient with generalized eruptive histiocytoma treated...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Hansel G,Schönlebe J,Tchernev G,Chokoeva AA,Lotti T,Wollina U

    更新日期:2015-01-01 00:00:00

  • The role of P53 and Bcl-2 proteins in 7, 12-dimethylbenz-(a)-anthracene-induced tumor growth.

    abstract::7, 12- Dimethylbenz-(a)-anthracene (DMBA) has been used for a long time to induce rat mammary gland carcinogenesis. In a previous paper we described the effects of diet, of non-steroidal anti-inflammatory drugs and the combination of these two factors on breast cancer. We also pointed out that DMBA tumor generating pr...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Miliaras S,Anogeianaki A,Kefala V,Miliaras D,Kokaraki G,Koutsonikolas D,Liangouris J,Anogianakis G

    更新日期:2011-07-01 00:00:00

  • Targeted ultrasound molecular imaging in mouse atherosclerotic plaque model.

    abstract::This study aims to assess the early diagnosis of mouse atherosclerotic plaque through targeted ultrasound molecular imaging. Forty Apolipoprotein E-deficient (ApoE-/-) mice and 40 C57BL/6 wild type mice were randomly divided into 4 groups, 20 mice per group. Mice included in the study group were fed with high choleste...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Zhou J,Tang YL,Sun YB,Song S,Yao LH

    更新日期:2017-07-01 00:00:00

  • Osteogenic properties of human dental pulp stem cells.

    abstract::Stem cells are a promising tool for bone tissue regeneration. Dental pulp stem cells (DPSCs) can be easily obtained even in human young adults. In this study we investigated the capability of DPSCs, to express the osteoblastic phenotype when cultured with osteogenic medium. DPSCs isolated from the dental pulp of impac...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Mori G,Centonze M,Brunetti G,Ballini A,Oranger A,Mori C,Lo Muzio L,Tetè S,Ciccolella F,Colucci S,Grano M,Grassi FR

    更新日期:2010-04-01 00:00:00

  • Neural correlates of observation of disgusting images in subjects with first episode psychosis and post-traumatic stress disorder.

    abstract::The aim of this study was to analyze neural responses to disgusting images in individuals with first episode psychosis and post-traumatic stress disorder (PTSD). Although anhedonia is a common symptom in both disorders we expected that they would be associated with different neurophysiological abnormalities and patter...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Vidotto G,Catalucci A,Roncone R,Pino MC,Mazza M

    更新日期:2014-10-01 00:00:00

  • IL-6 receptors and sensitivity to growth inhibition by IL-6 in clones of human breast carcinoma cells.

    abstract::Pure recombinant human IL-6 inhibits growth of T47D, MCF-7 and SK-BR-3 human breast carcinoma and OVCAR-3 ovarian carcinoma cells in cultures. Subcloning of the breast ductal carcinoma T47D cells yields clones with high and low sensitivity to the growth inhibitory effect of IL-6. The subclones vary 40 fold in their se...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Chen L,Shulman LM,Revel M

    更新日期:1991-10-01 00:00:00

  • Pubic osteolysis simulating a malignant lesion. A case report with long-term follow-up.

    abstract::Pubic osteolysis is a rare pathology characterized by a painful radiographic destructive changes in the pubic rami, pubis or pubic symphysis that often follows a post-traumatic event. The etiology is unclear but it is a benign lesion, frequently misinterpreted as malignant. We report a case of a 54-year-old woman with...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: XIX CONGRESSO NAZIONALE S.I.C.O.O.P. SOCIETA' ITALIANA CHIRURGHI ORTOPEDICI DELL'OSPEDALITA' PRIVATA ACCREDITATA.,De Maio F,Caterini A,Marsiolo M,Farsetti P

    更新日期:2019-03-01 00:00:00

  • Notch signaling is involved in regulation of LPS-induced macrophage apoptosis through JNK/NF-kB signaling pathway.

    abstract::Notch signaling plays a critical role in the development and function of macrophages. The aim of the present study was to investigate the relationship between Notch signaling pathway and macrophage apoptosis after LPS stimulation. In RAW 264.7 cells, the mRNA expression of Jagged1, Hes1, Hes 5 and GM-CSF, and protein ...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:10.23812/19-283-A

    authors: Chen GQ,Wang QM,Yu M,Cheng YD,Zhang ZC,Wang WS,Qiu Y,Sun LH,Peng K,Yang H

    更新日期:2020-02-12 00:00:00

  • Flake size-dependent cyto and genotoxic evaluation of graphene oxide on in vitro A549, CaCo2 and vero cell lines.

    abstract::This study was carried out by varying both graphene oxide (GO) concentration (10 μg/mL, 50 μg/mL, 100 μg/mL) and flakes sizes of 1320 nm and 130 nm. Characterization by scanning electron microscopy and Raman spectroscopy demonstrate that the area of GO flakes varies of one order of magnitude but their c...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: De Marzi L,Ottaviano L,Perrozzi F,Nardone M,Santucci S,De Lapuente J,Borras M,Treossi E,Palermo V,Poma A

    更新日期:2014-04-01 00:00:00

  • HIV therapy in the post-eradication era.

    abstract::Over the past three years, most efforts of virologists and immunologists involved in the field of Human Immunodeficiency Virus (HIV) have been focussed on strategies aimed at eradicating the infection. So far, however, all the approaches have been unsuccessful. Indeed, even if the currently available potent antiretrov...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Vella S,Palmisano L

    更新日期:2000-01-01 00:00:00

  • Association between HLA class II antigens and hepatitis C virus infection.

    abstract::The aim was to confirm the influence of HLA Class II antigens on the progression of HCV infection and to assess the relationship between these antigens and histological damage, HCV viral load and HCV genotype. 143 patients were enrolled and divided into three groups. Group A included 34 anti-HCV positive, HCV-RNA nega...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Scotto G,Fazio V,D'Alessandro G,Monno L,Saracino A,Palumbo E,Angarano G

    更新日期:2003-10-01 00:00:00

  • Paeoniflorin reduced the cardiotoxicity of aconitine in h9c2 cells.

    abstract::Aconitine (ACO), the main active component in Aconitum carmichaelii Debeaux (family: Ranunculaceae), has high cardiotoxicity, however the mechanisms of this effect remain unclear. Paeoniflorin (PF), the main chemical ingredient in herbaceous peony, can protect the heart from damage through antioxidant, vasodilatory an...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:10.23812/19-257A

    authors: Li J,Zhang SH,He D,Wang JF,Li JQ

    更新日期:2019-09-01 00:00:00

  • Comparative analysis of cleaning ability of two rotary instrument systems: Mtwo and ProTaper® universal. An in vitro scanning electron microscopic study.

    abstract::This study is to compare the cleaning effectiveness of two Ni-Ti files systems. Thirty single-rooted human teeth were selected and two NiTi rotary systems were used. Group A: canal shaping with ProTaper® Universal (Dentsply Tulsa Dental Specialties, Tulsa, OK) (PTU); Group B: (n=15) canal shaping with Mtwo Ni-Ti instr...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: DENTAL SUPPLEMENT.,Severino M,Libonati A,Di Taranto V,Montemurro E,Campanella V

    更新日期:2019-05-01 00:00:00

  • Oral-facial-digital syndrome (OFD): 31-year follow-up management and monitoring.

    abstract::Orofaciodigital syndrome (OFD) is a group of hereditary disorders identified by malformations of the mouth (oris), face (facies), hands and feet (digitus=finger and toe). Although there are several different types reported in the literature, there is a great overlap in their clinical presentation. The full spectrum of...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Minervini G,Romano A,Petruzzi M,Maio C,Serpico R,Di Stasio D,Lucchese A

    更新日期:2018-01-01 00:00:00

  • The comparison between vitamin d concentration in upper silesia patients with prostate cancer and with benign prostatic hyperplasia.

    abstract::A number of studies have shown that vitamin D has a protective effect against the development of cancer, which may also be related to prostate cancer. Low serum vitamin D concentration has also been demonstrated in benign prostate hyperplasia. We compared serum vitamin D concentration in two groups of Polish men with ...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 信件

    doi:

    authors: Wieczorek K,Braczkowski RS,Skrzypek M,Stryjewski PJ,Kuczaj A,Al-Srory G

    更新日期:2015-01-01 00:00:00

  • Clinical and radiographic short mid-term outcomes of primary total stabilizer knee arthroplasty.

    abstract::A successful Total Knee Arthroplasty (TKA) requires stability, but rarely in primary TKA, a prosthesis with more constraint than a posterior-stabilizer (PS) is necessary. In patients with severe varus/valgus deformities with incompetent collateral ligaments or in knees that cannot be adequately balanced after ligament...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Bonicoli E,Piolanti N,Giuntoli M,Polloni S,Ciapini G,Parchi PD,Scaglione M

    更新日期:2017-10-01 00:00:00

  • Prevention of surgery in children with adenoidal hypertrophy treated with intranasal flunisolide: a 12-month follow-up.

    abstract::Adenoidal hypertrophy (AH) represents one of the most frequent indications for surgery in children. Recently, treatment with intranasal corticosteroids has been suggested to decrease the size of AH. The aim of the study is to evaluate the long-term effect of intranasal flunisolide on AH during a 12-month follow-up. On...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Varricchio A,Tortoriello G,Capasso M,De Lucia A,Marchisio P,Varricchio AM,Mansi N,Giordano L,Liberatore G,Di Gioacchino M,Ciprandi G

    更新日期:2009-04-01 00:00:00

  • Different molecular subtypes of breast invasive ductal carcinoma.

    abstract::This study aims to analyze the clinical characteristics of breast invasive ductal carcinoma (BIDC) in patients with different molecular subtypes and identify possible correlation to prognosis. miR- 10b expression level was detected using real-time quantitative polymerase chain reaction (RT-PCR). Tissue sections were c...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Zheng LJ,Yang D,Sun LJ,Li SS,Wang JY,Ye SC

    更新日期:2018-05-01 00:00:00

  • NeuroAIDS: virological aspects of HIV infection.

    abstract::NeuroAIDS is one of the main complications of chronic HIV-infection. The Central Nervous System is an immunologic sanctuary for HIV and allows the persistence of the virus despite an efficient antiretroviral therapy. HIV-1 could promote the neurodegeneration through the induction of inflammation by the release of neur...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Surdo M,Cortese MF,Perno CF,Aquaro S

    更新日期:2013-04-01 00:00:00

  • Mast cell and cancer with special emphasis on il-37 an anti-inflammatory and inhibitor of innate immunity: new frontiers.

    abstract::Mast cells (MCs) are mediators of allergy and inflammation and participate in the growth of cancer cells. MCs can promote both neoangiogenesis and tumor growth. They increase in the stroma of certain tumors where they can be recruited by tumor-derived chemoattractants, such as monocyte chemotactic protein-1 (MCP-1), R...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 社论

    doi:

    authors: Carinci F,Lessiani G,Spinas E,Kritas SK,Ronconi G,Caraffa Al,Conti P

    更新日期:2016-10-01 00:00:00

  • Vitamins B12 and D deficiencies and macro- and microelement disturbances among diabetic elderly patients.

    abstract::Vitamin and mineral disturbances may interfere with glucose metabolism. Elderly persons with diabetes type 2 (T2DM) are more prone to mineral disturbances and vitamin deficiencies. The aim of this study was to analyze concentrations of vitamins B12 and D and macro- and microelements among diabetic elderly patients. Th...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 信件

    doi:

    authors: Dziegielewska-Gesiak S,Fatyga E,Kasiarz G,Wilczynski T,Muc-Wierzgon M,Kokot T

    更新日期:2019-03-01 00:00:00

  • IL-32: a newly-discovered proinflammatory cytokine.

    abstract::IL-32, a newly-discovered proinflammatory cytokine that activates the p38MAPK and NF-kappaB pathways, is an important player in innate and adaptive immune response. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the productio...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 社论,评审

    doi:

    authors: Felaco P,Castellani ML,De Lutiis MA,Felaco M,Pandolfi F,Salini V,De Amicis D,Vecchiet J,Tete S,Ciampoli C,Conti F,Cerulli G,Caraffa A,Antinolfi P,Cuccurullo C,Perrella A,Theoharides TC,Conti P,Toniato E,Kempuraj D,

    更新日期:2009-07-01 00:00:00

  • Animal models for cartilage repair.

    abstract::Cartilage lesions still represent an unsolved problem: despite the efforts of the basic and translational research, the regeneration of this tissue is far from being reached (1-3). Articular cartilage lesions can be divided in two main groups: superficial or partial defects and full-thickness defects (4, 5). Partial l...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章,评审

    doi:

    authors: Tessaro I,Nguyen VT,Di Giancamillo A,Agnoletto M,Verdoni F,Domenicucci M,Scurati R,Peretti GM,Mangiavini L

    更新日期:2018-11-01 00:00:00

  • Restoration of the degenerated cervical intervertebral space: how much should we distract? A magnetic resonance imaging study.

    abstract::The aim of the study was to quantify normal cervical disc space measurements and to generate a normal values' database. Furthermore, during operative restoration of a degenerated intervertebral disc, it is difficult to calculate the amount of distraction required to restore the collapsed space to its normal height. A ...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Fyllos AH,Zibis AH,Banios K,Mitrousias VD,Karantanas AH,Markou AS,Mangiavini L,Luceri F

    更新日期:2020-07-01 00:00:00

  • Study on the effectiveness of a nifedipine gel for treatment of Raynaud?s phenomenon.

    abstract::The aim of this study is to evaluate the efficacy of a nifedipine gel in patients with primary or secondary Raynaud?s phenomenon. Photopletismography was the instrumental examination test used to evaluate recovery time (time necessary for recuperation of normal capillary circulation) in 17 patients with primary or sec...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Foti C,Quaranta D,Pepe ML,Morea G,Mastropasqua D,D'Amore M,Mastrangelo F,Tete S,Grassi FR,Ballini A,Salini V,De Amicis D,Scagliusi P,De Lutiis MA,Caraffa A,Cerulli G

    更新日期:2006-07-01 00:00:00

  • Dimensional and microbiological in vitro analysis of a dental implant locking taper connection.

    abstract::The present study was carried out to compare the differences in contact, height and contact area between the implant-abutment interface and the implant-healing cap interface of an implant system featuring a locking tapered connection by using X-ray micro-tomography. It was also conducted to test in vitro whether the i...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 信件

    doi:

    authors: Giorgini G,Santangelo R,Bedini R,Pecci R,Manicone PF,Raffaelli L,Sanguinetti M,D ' Addona A

    更新日期:2013-10-01 00:00:00

  • C-reactive protein correlates to functional score systems of patients in general surgical intensive care unit.

    abstract::The aim of our study was to document the relationship between inflammation indicated by the serum levels of widespread acute-phase proteins and scoring systems used in assessing patient’s functional condition. We therefore assessed serum levels of c-reactive protein (CRP) and four clinical tests [acutephysiology and c...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Tian J,Liu X,Liu D

    更新日期:2016-01-01 00:00:00

  • RECONSTRUCTION OF THE ZYGOMATIC BONE WITH SMARTBONE®: CASE REPORT.

    abstract::The repair of complex craniofacial bone defects is challenging and a successful result depends on the defect size, the quality of the soft tissue covering the defect and the choice of reconstructive method. Autologous bone grafts are the gold standard for bone replacement. Tissue engineered constructs are temporary su...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Grecchi F,Perale G,Candotto V,Busato A,Pascali M,Carinci F

    更新日期:2015-07-01 00:00:00