Abstract：
:The aim of this work was to study the effects of micro ribonucleic acid (miR)-20a on acute kidney injury (AKI) in sepsis rats and its key molecular mechanism. Sprague-Dawley rats were randomly divided into healthy rat group (H group, n=3), sham group (S group, n=3), sepsis rat group (D group, n=3), sepsis rat + negative control transfection group (N group, n=3) and sepsis rat + miR-20a inhibitor transfection group (M group, n=3). At 6 h, 12 h and 24 h, serum creatinine (Scr) and blood urea nitrogen (BUN) were detected, the changes in miR-20a expression in kidney tissues were determined via reverse transcription-polymerase chain reaction (RT-PCR), the expression of autophagy marker protein microtubule-associated protein 1 light chain 3 (LC3) was measured via Western blotting, and the inflammatory cell infiltration in kidney tissues was detected using hematoxylin-eosin (HE) staining. There was no obvious change in each index in S group compared with H group. D group, N group and M group had higher levels of Scr, BUN and LC3 in kidney tissues than S group. The levels of Scr, BUN and LC3 in kidney tissues were lower in M group than those in N group. MiR-20a may cause AKI in sepsis rats via activating autophagy.
journal_name
J Biol Regul Homeost Agentsjournal_title
Journal of biological regulators and homeostatic agentsauthors
Wang JX,Tao YL,Wang Z,Mao QJdoi
10.23812/20-174-Asubject
Has Abstractpub_date
2020-07-01 00:00:00pages
1277-1283issue
4eissn
0393-974Xissn
1724-6083pii
10journal_volume
34pub_type
杂志文章abstract：:Despite a wide range of available antidepressants, the effect of the treatment is often suboptimal and there is a need for more effective and better tolerated drugs. Unlike other antidepressants, agomelatine represents a new approach to depression with an innovative mechanism of action. It is an agonist of melatoniner...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：2011-01-01 00:00:00
abstract：:Sjögren's Syndrome is a complex disease, due to an autoimmune physiopathology, that strongly impacts both patients' primary needs (nutrition and speaking), and patients' relationship life related factors (psychological health and quality of life). In Literature, few studies had investigated oral health status in Sjögr...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2020-05-01 00:00:00
abstract：:Anxiety and worry are important components that affect the patients behaviour during dental sessions and influence the effectiveness of dental treatment. Psychological approach and hypnotic approach (HA) have in recent years assumed increasing prominence as effective treatment regimes. Dentists have used a number of ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
abstract：:The aim of this study is to evaluate the efficacy of a nifedipine gel in patients with primary or secondary Raynaud?s phenomenon. Photopletismography was the instrumental examination test used to evaluate recovery time (time necessary for recuperation of normal capillary circulation) in 17 patients with primary or sec...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
abstract：:The aim of this work is to assess the level of the human alkaline phosphatase enzyme (ALP) during palatal expansion with Quad-Helix (QH) appliance. A total of twenty-two orthodontic patients characterized by contraction of the upper jaw, that needed application of a QH in order to treat their condition, were included ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
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更新日期：2015-10-01 00:00:00
abstract：:The aim of our study was to document the relationship between inflammation indicated by the serum levels of widespread acute-phase proteins and scoring systems used in assessing patients functional condition. We therefore assessed serum levels of c-reactive protein (CRP) and four clinical tests [acutephysiology and c...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2016-01-01 00:00:00
abstract：:Pirfenidone is an antifibrotic agent for patients with pulmonary fibrosis, but this drug has adverse gastrointestinal (GI) effects. The first aim of this study was to assess GI symptoms due to pirfenidone by using a new questionnaire for reflux symptoms and dismotility symptoms. Whether adding herbal medicine of rikku...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2014-07-01 00:00:00
abstract：:Allergen-specific immunoglobulin E (IgE) reactions lead to acute degranulation of mast cells and basophils and release of stored mediators, particularly tryptase and histamine, which can be measured in vitro after reactions. The aim of this study was to investigate the utility of serum tryptase and plasma histamine du...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2015-04-01 00:00:00
abstract：:Respiratory viral infections may worsen bronchial hyperreactivity. However, there is no data on the possible role of recurrent infectious rhinitis in nose hyperreactivity. This study was therefore designed to investigate whether subjects suffering from recurrent common cold have nasal hyperreactivity, assessed by hist...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2011-04-01 00:00:00
abstract：:A high heterogeneity is found in the HIV-1 genome in vivo, not only between individuals, but also within a single individual. Different types of genetic heterogeneity of HIV-1 can be analyzed: the extension and the evolution of the viral quasispecies in blood, the variation between the virus obtained from different bo...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
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更新日期：2018-11-01 00:00:00
abstract：:The pseudoarthrosis (PSA) of scaphoid leads to alteration in load transfer in the wrist joint. Its treatment aims to achieve consolidation to improve clinical complaints and prevent post-traumatic arthritis. The indication for using vascularized bone grafts is still controversial. This prospective comparative study ai...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 临床试验
doi：
更新日期：2020-05-01 00:00:00
abstract：:Many studies demonstrated that human adult cardiac progenitor cells in the form of cardiospheres (CSps) could represent a powerful candidate for cardiac cell therapy. To achieve the clinical translation of this biotechnological product, the development of well-defined culture conditions is required to optimize their p...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2011-04-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
更新日期：2015-04-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,评审
doi：
更新日期：1999-07-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2016-01-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2019-05-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
abstract：:Percutaneous techniques for treatment of thoraco-lumbar fractures type A2 and A3 are widely used. These techniques are considered temporary fixations and instrumentation must be removed with fracture healing. The aim of the study is to analyze clinical results, motility of treated segments and any loss of correction a...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2018-05-01 00:00:00
abstract：:The selection of a kidney graft recipient should be made not only taking into account biological and clinical parameters, for assuring the maximum possible clinical success; the ethical objective to allow every patient equal opportunity of receiving a transplant should also be pursued. In every waiting list of transpl...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Generalized eruptive histiocytoma is a rare benign skin disorder with less than 50 cases reported world-wide. It belongs to type IIb of histiocytoses. The histiocytic cells are CD68 positive but lack other markers like CD1a or S100. We report on a 60-year-old male patient with generalized eruptive histiocytoma treated...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2009-04-01 00:00:00
abstract：:Ahead of Print article withdrawn by publisher. ...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 社论,收录出版
doi：10.23812/20-269-E-4
更新日期：2020-07-16 00:00:00
abstract：:The state of sleep/wakefulness is well known to influence esophageal acid exposure and the number of acid refluxes whereas it is uncertain whether the same is true of the non-acid refluxes that predominate in the newborns. To investigate the relationship between sleep/wakefulness and refluxes 45 newborns with gastroes...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
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更新日期：2019-03-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2019-01-01 00:00:00
