Abstract:
:This paper aimed to raise a thin-layer chromatography (TLC) identification method for rhubarb and Phellodendri Amurensis Cortex and inspected skin irritation induced by them. It applied the TLC identification for Rhubarb and Phellodendri Amurensis Cortex in Shuang-bai cataplasm prescription. In this study six rabbits were divided into two groups to observe the skin irritation from Shuang-bai cataplasm on intact and defected skin. Another 36 were randomly divided into 6 groups to observe the acute toxicity from Shuang-bai cataplasm on intact and defected skin. Also 30 guinea pigs were divided into 3 groups to observe skin allergy to Shuang-bai cataplasm. The results showed that the average weight of the group of intact-skin rabbits was 2.026±0.10 kg and 2.427±0.023 kg after medication; the average weight of the group of defected-skin rabbits was 2.170±0.05 kg and 2.540±0.15 kg after medication; Shuang-bai cataplasm produced no irritation on intact or defected rabbit skin, no acute toxicity in rabbits and no allergy on the skin of guinea pigs. The skin allergy rate on guinea pigs of the medication group was 0 at each time quantum. Therefore, it can be concluded that this preparation produces no extreme skin irritation for rabbits, guinea pigs or human beings, and it can be safely put into practice.
journal_name
J Biol Regul Homeost Agentsjournal_title
Journal of biological regulators and homeostatic agentsauthors
Tian YG,Qin SM,Ding Lsubject
Has Abstractpub_date
2015-04-01 00:00:00pages
479-84issue
2eissn
0393-974Xissn
1724-6083pii
28journal_volume
29pub_type
信件abstract::Body weight is controlled by our genes and managed by a neuro-hormonal system, in particular by insulin and glucagon. The meristematic extract of Japanese white mulberry blocks the alpha-glucosidase and then the intestinal hydrolysis of polysaccharides, thereby reducing the glycaemic index of carbohydrates. The target...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 临床试验,信件
doi:
更新日期:2014-01-01 00:00:00
abstract::IL-32, a newly-discovered proinflammatory cytokine that activates the p38MAPK and NF-kappaB pathways, is an important player in innate and adaptive immune response. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the productio...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 社论,评审
doi:
更新日期:2009-07-01 00:00:00
abstract::Glycoprotein Ia (GPIa), also known as integrin alpha 2 (ITGA2), together with GPIIa (ITGB1), form the heterodimer integrin α2β1. This complex is a major collagen receptor on the membrane of platelets, which is involved in thrombus formation through platelet adhesion and activation. ...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
doi:
更新日期:2019-05-01 00:00:00
abstract::Degenerative osteoarthropathy, a kind of arthrosis induced by various factors, mainly affects articular cartilage and causes syndesmophyte formation. Its morbidity increases year by year, tending to occur more among young people than previously. This paper mainly discusses the clinical effects of iontophoresis of the ...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件,随机对照试验
doi:
更新日期:2015-01-01 00:00:00
abstract::A successful Total Knee Arthroplasty (TKA) requires stability, but rarely in primary TKA, a prosthesis with more constraint than a posterior-stabilizer (PS) is necessary. In patients with severe varus/valgus deformities with incompetent collateral ligaments or in knees that cannot be adequately balanced after ligament...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2017-10-01 00:00:00
abstract::Acute abdominal aortic thrombosis is a rare and potential fatal event, which occurs in adult subjects. We present the case of a 72-year-old-man, who referred to the emergency Department of our hospital because of persistent severe abdominal and perineal pain. Doppler ultrasounds and computerized tomography angiography...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
doi:
更新日期:2013-04-01 00:00:00
abstract::End-stage renal diseases requiring chronic dialysis are rare in childhood and adolescence, but they are associated with high mortality and impaired quality of life (1, 2). The most common disease that causes chronic kidney disease (CKD) is primary glomerular disease (GD), followed by congenital abnormalities of the ki...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 临床试验
doi:
更新日期:2019-09-01 00:00:00
abstract::Osteoarthritis (OA) represents an inflammation-driven injury of articular tissues, progressively leading to structural and functional joint impairment. The main symptom of OA is pain. Although it has been well established that OA represents a whole joint disease, the source of pain remains to be clarified. Nowadays, i...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2020-07-01 00:00:00
abstract::Flow cytometric enumeration of CD34+ hematopoietic stem and progenitor cells (HPC) is widely used for evaluation of graft adequacy of peripheral blood stem cell grafts, and is also useful in planning the apheresis sessions necessary to obtain these grafts. The state-of-the-art method to enumerate CD34+ cells makes use...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
abstract::Skeletal muscle injuries are common causes of severe long-term pain and physical disability, accounting for up to 55% of all sports injuries. The phases of the healing processes after direct or indirect muscle injury are complex but clearly defined and include well-coordinated steps: degeneration, inflammation, regene...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2015-10-01 00:00:00
abstract::Allergic rhinitis (AR) is caused by an IgE-mediated inflammatory reaction. Non-allergic rhinitis (NAR) is characterized by a non-IgE-mediated pathogenesis. Frequently, patients have the two disorders associated: such as mixed rhinitis (MR). Hyaluronic acid (HA) is a fundamental component of the human connective tissue...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2016-01-01 00:00:00
abstract::The Janus kinase-signal transducers and activators of transcription signaling pathway (JAK/STAT pathway) have displayed a critical role in tumor development and progression in multiple malignancies. Previous studies showed that inhibition of JAK/STAT signaling blocked cell growth and metastasis in cancer cells, howeve...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to investigate the value of Gd-EOB-DTPA-enhanced MRI on hepatobiliary phase (HBP) imaging and T1 mapping sequence in the differentiation of hepatocellular carcinoma (HCC). A total of 45 patients with HCC who were to undergo a resection were enrolled in this study. Gd-EOB-DTPA-enhanced magneti...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2017-10-01 00:00:00
abstract::Peripheral nerve injury in surgical trauma patients is very common. The femoral nerve can be divided into two branches: one regarding the quadricep muscles, and one the skin. After nerve transection and suture, the motor axons have an equal opportunity to regenerate into the original muscle branch, or regenerate into ...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2017-04-07 00:00:00
abstract::The state of sleep/wakefulness is well known to influence esophageal acid exposure and the number of acid refluxes whereas it is uncertain whether the same is true of the non-acid refluxes that predominate in the newborns. To investigate the relationship between sleep/wakefulness and refluxes 45 newborns with gastroes...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2012-07-01 00:00:00
abstract::Although viscosupplementation has been used in the past few years both for knee and hip osteoarthritis (OA), the number of intra-articular injections and the interval between doses still remains an undetermined subject. The aim of this open retrospective study was to evaluate the clinical and functional outcome in pat...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
doi:
更新日期:2018-09-01 00:00:00
abstract::In the aesthetic field, successful replacement of a tooth with a dental implant requires blend and harmony within the existing dentition. The influence of the dimension of buccal bone at implant sites on aesthetic outcomes and the relation between buccal bone horizontal and vertical dimensions are unclear. The aim of ...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2017-04-01 00:00:00
abstract::The aim of this study is to explore the regulatory effect of micro ribonucleic acid (miR)-19a on diabetic retinopathy (DR) through mediating the phosphatase and tensin homolog deleted on chromosome ten (PTEN)/protein kinase B (Akt) signaling pathway. Thirty male Sprague-Dawley rats were first divided into Healthy grou...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:10.23812/20-77-A-60
更新日期:2020-03-01 00:00:00
abstract::Acute coronary syndrome (ACS) is the acute stage of coronary artery disease, which remains a major cause of mortality and morbidity. It is essential to explore the role of matrix metalloproteinase -2 (MMP-2) and interleukin (IL)-18 and their association with disease in patients with severe ACS. Circulating MMP-2 and I...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
doi:
更新日期:2018-03-01 00:00:00
abstract::An anti-CD38 mAb (IB4) coupled to saporin-S6, a type 1 ribosome-inactivating protein (RIP), was designed for ex vivo or loco-regional therapeutical applications in myeloma and lymphoma. The ability of this immunotoxin to eliminate CD38+ cells was studied in vitro on selected CD38+ human cell lines (Raji, HBL6, L540 an...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2005-07-01 00:00:00
abstract:: ...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
doi:
更新日期:2019-01-01 00:00:00
abstract::This case report presents the technique of deep infiltration for the treatment of hypomineralized enamel lesions in a patient affected by molar incisor hypomineralization (MIH) with the purpose of obtaining an aesthetic improvement in the affected vestibular enamel. Deep infiltration treatment involves a sequence of s...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2018-05-01 00:00:00
abstract::Poly(ADP-ribose) polymerase (PARP) is a 116kDa enzyme catalysing the synthesis of ADP-ribose polymers from NAD+. PARP is activated in response to DNA strand breaks and plays a critical role in the maintenance of genomic integrity. However, considering its role also in transcription, proliferation as well as apoptosis ...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
doi:
更新日期:2014-10-01 00:00:00
abstract::Fat transplantation experiments have previously shown regulatory properties of lean adipose tissue on glucose homeostasis in the whole animal. In the current study, we addressed whether obese visceral white adipose tissue grafted in lean mice could alter glucose homeostasis. Obese visceral fat (VF) tissue was effectiv...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2012-07-01 00:00:00
abstract::Activated T-cells are susceptible to induction of apoptosis or programmed cell death in response to ligation of several cell surface structures, including CD2, CD3, and CD95/Fas. These mechanisms may be important in the regulation of immune responses and in prevention of autoimmunity. We used flow cytometric quantitat...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::A potential role of Helicobater Pylori (HP) infection in several extra-intestinal pathologies has been recently suggested. The aim of our study was to assess the role of serology positive for HP in atopic and non atopic infants and children affected by atopic dermatitis, urticaria, rhinitis and asthma. We included 615...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::Vitamin and mineral disturbances may interfere with glucose metabolism. Elderly persons with diabetes type 2 (T2DM) are more prone to mineral disturbances and vitamin deficiencies. The aim of this study was to analyze concentrations of vitamins B12 and D and macro- and microelements among diabetic elderly patients. Th...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
doi:
更新日期:2019-03-01 00:00:00
abstract::Both mouse interferon-beta (MuIFN-beta) and the inhibitor of ornithine decarboxylase (ODC), alpha-difluoromethyl ornithine (DFMO), inhibited the differentiation of mouse 3T3-L1 fibroblasts into adipocytes in a dose-dependent manner. DFMO and MuIFN-beta added together to cultures that were induced to differentiate prod...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::Nitric oxide (NO) has emerged as a potent effector molecule for a post-resuscitation disease as a result of the low-energy defibrillation. In this article, the authors anlysed the changes of endogenous nitric oxide levels in serum of 35 healthy rabbits after the transthoracic application of low-energy two-phase shock ...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2017-04-01 00:00:00
abstract::To compare the effectiveness of Doctor Tecar TherapyTM with that of laser therapy in the management of low back pain (LBP), a total of 60 patients with LBP were enrolled. The participants were randomly divided into two groups: a Tecar group (experimental group, 30 subjects), and a laser group (control group, 30 subjec...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2017-04-01 00:00:00