Abstract：
:Acute coronary syndrome (ACS) is the acute stage of coronary artery disease, which remains a major cause of mortality and morbidity. It is essential to explore the role of matrix metalloproteinase -2 (MMP-2) and interleukin (IL)-18 and their association with disease in patients with severe ACS. Circulating MMP-2 and IL-18 levels were measured using enzyme linked immunosorbent assay (ELISA) in 94 subjects with acute coronary syndrome (ACS, n=38), stable angina pectoris (SAP, n=27) and healthy individuals (control group, n=29). We examined the correlations between the levels of MMP-2 and IL-18 and cardiac risk factors in ACS. Logistic regression analysis was performed to screen for factors that predict ACS. Both MMP-2 and IL-18 concentrations were increased in the ACS group compared to the SAP group or control group (P less than 0.01). Especially, MMP-2 and IL-18 were highly expressed in the patients with ST elevated myocardial infarction (STEMI). Both serum levels of MMP-2 and IL-18 in the single-, double- and triple-vessel lesion group were higher compared to the control group (P less than 0.01). MMP-2 levels were positively correlated with IL-18 (r=0.639, P less than 0.01), CK-MB (r=0.47, P=0.003) and hs-CRP levels (r=0.583, P less than 0.01). The logistic regression analysis showed that increases in MMP-2 levels may be a powerful predictor of ACS. Thus, the changes in levels of serum MMP-2 and IL-18 may be useful in the diagnosis of ACS and prediction of its prognosis.
journal_name
J Biol Regul Homeost Agentsjournal_title
Journal of biological regulators and homeostatic agentsauthors
Sun H,Zhang J,Zheng Y,Shang Ssubject
Has Abstractpub_date
2018-03-01 00:00:00pages
299-305issue
2eissn
0393-974Xissn
1724-6083pii
15journal_volume
32pub_type
信件abstract：:Upper respiratory infections are widespread in clinical practice. Antibiotics are frequently used in the management of patients with airways infection. However, antibiotics can induce intestinal and respiratory dysbiosis that, in turn, worsens respiratory symptoms. Moreover, respiratory infections per se can cause dys...
journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,评审
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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doi：
更新日期：2000-01-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：10.23812/19-342-A
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,评审
doi：
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
doi：
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章,评审
doi：
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 杂志文章
doi：
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 信件
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journal_title：Journal of biological regulators and homeostatic agents
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doi：
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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doi：
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journal_title：Journal of biological regulators and homeostatic agents
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更新日期：2012-04-01 00:00:00
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
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doi：
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journal_title：Journal of biological regulators and homeostatic agents
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journal_title：Journal of biological regulators and homeostatic agents
pub_type： 社论
doi：
更新日期：2013-04-01 00:00:00
