Abstract:
:In an effort to define immunobiological parameters identifying "responders" vs "non-responders" to IFN among hepatitis patients, 16 patients with chronic active hepatitis were screened for changes of Natural Killer cell activity (NK). 10/16 patients replicated the hepatitis B virus (HBV-DNA positive) whereas 6/16 replicated the defective B virus associated delta virus (HDV-RNA positive). Patients received 9 MU/3x/weekly/3 months of recombinant IFN alpha A. Mean NK activity of the HBV-DNA patients rose significantly from 29.9 +/- 5.3 to 45 +/- 4.7 during therapy, whereas the 6/16 HDV-RNA positive patients did not show any significant increase of NK activity. Interestingly, individual HDV-RNA positive patients exhibiting boosted NK activity also showed improvement of disease confirmed by clearance of intrahepatic delta antigen at one year. No such a correlation was found amongst the HBV-DNA positive patients. These data indicate that in spite of widespread individual variability, IFN-mediated NK boost may herald delta clearance and help in identifying "responders" and "non-responders" in IFN trials.
journal_name
J Biol Regul Homeost Agentsjournal_title
Journal of biological regulators and homeostatic agentsauthors
Actis GC,Maran E,Bonino F,Saracco G,Rosina F,Brunetto MR,Baldi M,Rizzetto M,Verme G,Rocca Bsubject
Has Abstractpub_date
1987-01-01 00:00:00pages
45-50issue
1eissn
0393-974Xissn
1724-6083journal_volume
1pub_type
杂志文章abstract::Articular cartilage lesions represent a challenging problem for orthopaedic surgeons. The purpose of this study was to evaluate the effect of a new pulsed Nd:YAG High Intensity Laser Therapy on the regeneration of cartilage tissue in patients with traumatic lesions. Clinical, histological and immunohistochemical evalu...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2012-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 临床试验
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
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更新日期:2019-03-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 社论
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2015-07-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2020-07-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
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更新日期:2020-07-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2005-07-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2014-04-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
doi:
更新日期:2015-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 临床试验,杂志文章
doi:
更新日期:2018-03-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2020-11-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
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更新日期:2018-07-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2017-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:10.23812/20-75A
更新日期:2020-04-29 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件,评审
doi:
更新日期:2016-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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doi:
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,评审
doi:
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,评审
doi:
更新日期:2018-11-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,评审
doi:
更新日期:2020-11-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
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更新日期:2012-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
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