Abstract:
:The mechanisms of genetic resistance or "trypanotolerance" to infection with Trypanosoma congolense were investigated in two strains of mice. One strain C57BL, is outstandingly resistant to most stabilates of T. congolense and can survive for over 80 days, whereas CFLP, in common with most other strains, generally succumbs in less than 20 days. Evaluation of several pathophysiological and immunological parameters showed that after infection both strains initially developed similar levels of parasitemia, anemia, biochemical derangement, and immunosuppression. The most outstanding difference was after day 8 postinfection, when the susceptible strain (CFLP) sustained high levels of parasitemia (10(9) trypanosomes per ml) until death 2 to 4 days later, whereas the resistant strain (C57BL) showed a marked decrease to less than 10(6) trypanosomes per ml by day 10 postinfection. Clear evidence that this was associated with the presence of trypanocidal antibody in the resistant mice was provided by the results of an infectivity neutralization test on serum collected from each strain at 10 days postinfection. Chronically infected C57BL mice showed declining waves of parasitemia and a slow restoration of most hematological and biochemical indexes to near normal levels by 80 days postinfection, although at this stage they remained immunosuppressed.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Whitelaw DD,Macaskill JA,Holmes PH,Jennings FW,Urquhart GMdoi
10.1128/IAI.27.3.707-713.1980subject
Has Abstractpub_date
1980-03-01 00:00:00pages
707-13issue
3eissn
0019-9567issn
1098-5522journal_volume
27pub_type
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journal_title:Infection and immunity
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doi:10.1128/IAI.32.2.641-648.1981
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.5.1374-1379.1989
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.7.6.918-921.1973
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pub_type: 杂志文章
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journal_title:Infection and immunity
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doi:10.1128/IAI.67.1.433-435.1999
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.5.1360-1368.1990
更新日期:1990-05-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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journal_title:Infection and immunity
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更新日期:1990-01-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1997-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1987-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.24.3.920-924.1979
更新日期:1979-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-07-01 00:00:00