Abstract：
:The results of a series of studies on body fluid, electrolytes and diuretics are discussed. The findings to date indicate that the sex difference between mean potassium plasma levels in men and women is preserved into old age. Contrary to previous suggestions, there would appear to be no transient self-correcting hypokalaemia associated with illness uncomplicated by potassium-losing therapy, and treatment with potent loop diuretics, provided it is accompanied by potassium supplementation, does not commonly give rise to hypokalaemia even in elderly patients. It has not been possible so far to confirm the relationship between total exchangeable sodium and blood pressure, as previously suggested in elderly patient with essential hypertension. It has been shown that hypokalaemia of a mild degree is associated with an increase in the number of ventricular ectopic beats. It is suggested, therefore, that the conclusion that mild hypokalaemia (between 3.0 and 3.5 mmol/l) is of no significance, at least as far as elderly patients are concerned, may well be untrue.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
McCarthy STsubject
Has Abstractpub_date
1982-01-01 00:00:00pages
87-95issue
Suppl 1eissn
0300-7995issn
1473-4877journal_volume
7pub_type
杂志文章abstract：OBJECTIVE:PREDICTIVE is a multi-national, prospective, observational study, assessing the safety and efficacy of insulin detemir in patients with diabetes. RESEARCH DESIGN AND METHODS:The European cohort includes 20,531 patients with diabetes (7420 type 1) from 11 countries. A subgroup of 4782 type 1 patients were tra...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1185/030079908x260835
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:To evaluate intraocular pressure (IOP)-lowering efficacy, tolerability, and safety of the fixed combination of bimatoprost 0.03% and timolol 0.5% (Ganfort) among German patients. METHODS:Multicenter, observational, open-label study of patients with primary open angle glaucoma or ocular hypertension (n = 606)...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究
doi：10.1185/03007990902816947
更新日期：2009-04-01 00:00:00
abstract：:Poor nutritional status may impair well being indirectly as a consequence of increased morbidity and decline in functional status. The aim of this study was to examine the independent effect of body mass index on the well being of older people. Thirty one hospital-based patients over 65 years of age were studied. Well...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:To look into current evidence exploring the added value of rLH supplementation to rFSH in GnRH analogues cycles, to identify groups of women that still have no evidence for adjuvant rLH therapy and to discuss ways that may advance research on this topic. METHODS:Eight systematic reviews and meta-analyses exp...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2017.1417827
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Tobacco smoking is a major risk factor for cardiovascular disease, respiratory disease and cancer and, for current smokers, smoking cessation is one of the most effective therapeutic interventions for reducing the risk of all-cause morbidity and mortality. However, smoking cessation causes nicotine withdrawa...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007990802707600
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVES:Many insulin-treated patients with type 2 diabetes (T2D) do not reach hemoglobin A1c (HbA1c) < 7%, but have clinically relevant HbA1c reductions. Using an integrated database (IDB) of 53 insulin lispro clinical trials and a real-world evidence (RWE) database of T2D patients initiating insulin therapy, an exp...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2017.1396968
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:Using a Delphi Consultation process, a group of medical writers established by the European Medical Writers Association (EMWA) set out to determine the current thinking on the problems of ghostwriting in medical publications and what should be done about them. In this context, ghostwriting is where a professi...
journal_title：Current medical research and opinion
pub_type： 指南,杂志文章
doi：10.1185/030079905x25569
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVE:To examine outcomes associated with colesevelam treatment among patients with hypercholesterolemia in real-world clinical practice. METHODS:This analysis was conducted as a retrospective, observational cohort study in an ambulatory-care medical network in Northern California. Patients with orders for colesev...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1185/03007995.2013.842162
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVE:Thiazide diuretics such as hydrochlorothiazide (HCT) are a widely used first-line treatment for hypertension, but most patients will not achieve blood pressure (BP) control with HCT alone and so will require combination therapy. In this study the efficacy, safety and tolerability of a single-pill combination ...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1185/03007990902804158
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:To systematically identify and assess current quality measures for anticoagulation in atrial fibrillation (AF), venous thromboembolism (VTE) treatment and surgical VTE prophylaxis. RESEARCH DESIGN AND METHODS:Fifteen quality measure websites were searched as were bibliographic databases (January 2000-Februar...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2016.1200020
更新日期：2016-10-01 00:00:00
abstract：:A double-blind controlled, cross-over trial was carried out in 70 depressed patients to compare the effectiveness and tolerability of amineptine with that of maprotiline. Patients were allocated at random to receive treatment with either 150 mg amineptine or 75 mg maprotiline daily for 6 weeks before being treated for...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007997909109406
更新日期：1979-01-01 00:00:00
abstract：OBJECTIVES:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. A high level of low-density lipoprotein cholesterol (LDL-C) is a major CVD risk factor. Guidelines recommend effective cholesterol management and set LDL-C goals, yet deficiencies exist in physician implementation of these recommendati...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079908x280491
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVES:To compare retinal thickness before and after treatment with the fluocinolone acetonide (FAc) 190 µg intravitreal implant in people with diabetic macular edema (DME) using data from the Iluvien Clinical Evidence study in the UK (ICE-UK). METHODS:For this retrospective cohort study, data on people attending ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2017.1366662
更新日期：2017-10-01 00:00:00
abstract：:A clinical trial was undertaken in 50 patients with osteoarthritis of the knee to assess the therapeutic value of glycosaminoglycan-peptide complex in treatment. The first year consisted of a randomized, double-blind, placebo-controlled, parallel-group trial (25 patients in each group), after which all patients receiv...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007998709112416
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVES:Eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist, has been shown to increase platelet counts in adults with chronic immune thrombocytopenia and chronic hepatitis C. This multicenter phase 2 study assessed the efficacy and safety of eltrombopag in patients receiving first-line carboplatin/pacl...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1185/03007995.2010.510051
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVE:The objectives of this survey were to understand (1) the effects of overactive bladder (OAB) and urinary incontinence (UI) on women's lives and to understand (2) women's needs and expectations of health care providers and treatment related to these disorders. METHODS:Women (N = 1046) with self-reported sympt...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079905X59076
更新日期：2005-09-01 00:00:00
abstract：:The potential advantages of eletriptan lie firstly in its lipophilicity reflected as an increased rate of absorption and Tmax compared to sumatriptan. This is manifested in a modest advantage over sumatriptan in terms of speed of onset, 2 h headache response and 2 h pain free. However, eletriptan has not yet been show...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/0300799039117004
更新日期：2001-01-01 00:00:00
abstract：:A clinical evaluation was carried out in 19 patients with lichen ruber planus to assess the effectiveness of 0.05% betamethasone-17,21-dipropionate ointment in the treatment of patients whose lesions had developed resistance to prolonged treatment with 0.1% betamethasone-17-valerate ointment. The new steroid ointment ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007997609109305
更新日期：1976-01-01 00:00:00
abstract：BACKGROUND:Development of a second primary malignancy (SPM) after an index esophageal cancer is fairly rare, primarily due to decreased survival in patients with esophageal cancer. However, with advances in early detection and therapy, the number of long-term survivors is increasing, as is the incidence of SPMs in this...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007995.2013.816276
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVE:These studies evaluated the safety and efficacy of enteric-coated budesonide for the induction and maintenance of remission of mild-to-moderate Crohn's disease (CD) in children. METHODS:The consecutive, multicenter, open-label, non-comparative studies enrolled patients aged 6-17 years. In the induction study...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1080/03007995.2017.1313213
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:To identify determinants of non-compliance with bisphosphonates in women with postmenopausal osteoporosis. By considering the year of the introduction of weekly bisphosphonates important additional information is obtained. METHODS:New female users of daily or weekly alendronate or risedronate between 1999 an...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079908x297358
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:Postpartum depression (PPD) is the most common medical complication of childbirth. PPD can be disabling, with potential negative effects on maternal health-related quality-of-life (HRQoL) as well as on children and partners. The objective of this study was to systematically review and summarize recently publi...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2018.1552039
更新日期：2019-03-01 00:00:00
abstract：OBJECTIVE:To evaluate knowledge about risks, prevention and consequences of infection with hepatitis B virus (HBV) among travellers from four low HBV risk, European countries. METHODS:Individuals from an internet panel and based in the Czech Republic, the Netherlands, Spain and Sweden were invited to take part in an o...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007995.2010.546392
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVE:To review the pharmacoeconomic literature evaluating use of antihistamines in treating allergic rhinitis (AR) in the US. METHODS:Three independent reviewers conducted a comprehensive search of the current literature with PubMed. They identified articles describing original research comprising US cost analyse...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007990902875992
更新日期：2009-06-01 00:00:00
abstract：:An open, multi-centre study was carried out in 804 patients complaining of sleep disorders to assess the effectiveness and acceptance of temazepam as a hypnotic. Patients received between 10 mg and 30 mg (mean 16.4 mg) temazepam each night for a week. Subjective assessments using a self-administered questionnaire were...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007997809111918
更新日期：1978-01-01 00:00:00
abstract：:In a double-blind, partial cross-over study of 141 patients with mild to moderate hypertension, chlorthalidone 50 mg was compared with chlorthalidone 50 mg/triamterene 50 mg combination treatment. The study assessed clinical efficacy in the reduction of blood pressure, and safety with regard to serum potassium concent...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章
doi：10.1185/03007999609111560
更新日期：1996-01-01 00:00:00
abstract：:Twenty-five acutely disturbed psychotic patients were treated in an open study with a single injection of zuclopenthixol acetate 5% in 'Viscoleo, a thin vegetable oil. Patients were assessed post-injection for 3 days using the BPRS, CGI, and a specially designed behaviour/activity scale. Doses of 50 to 150 mg proved e...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007999009111492
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:As results from an increasing number of clinical trials with disease-modifying drugs (DMDs) in multiple sclerosis (MS) become available, the challenge for the treating neurologist is how to decide on the appropriate therapy for an individual patient. OBJECTIVE:An International Working Group for Treatment Op...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007x233007
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:To estimate the costs and consequences of using pamidronate compared to zoledronic acid in the prophylactic management of skeletal morbidity among breast cancer patients in the UK. DESIGN AND SETTING:This was a modelling study performed from the perspective of the UK's National Health Service (NHS). METHODS...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079905X40472
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:Patients with type 2 diabetes (T2DM) often have multiple comorbidities which may impact the selection of antihyperglycemic therapies. The purpose of this study was to quantify the prevalence and co-prevalence of common comorbidities. RESEARCH DESIGN AND METHODS:A retrospective study was conducted using the Q...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007995.2016.1168291
更新日期：2016-07-01 00:00:00
