Abstract:
OBJECTIVE:To look into current evidence exploring the added value of rLH supplementation to rFSH in GnRH analogues cycles, to identify groups of women that still have no evidence for adjuvant rLH therapy and to discuss ways that may advance research on this topic. METHODS:Eight systematic reviews and meta-analyses exploring the benefit for pregnancy achievement of rLH supplementation, excluding other LH activity preparations, to GnRH analogues cycles in the ART setting were thoroughly evaluated. RESULTS:Evidence exists to show that rLH supplementation seems to have added value for pregnancy achievement in women with poor ovarian response and in women ≥35 years of age employing the GnRH agonist protocol, while the evidence is still debatable when the GnRH antagonist is administered. In the general infertile population, rLH supplementation does not have added value in the GnRH-antagonist cycles while the evidence is still controversial when the GnRH agonist is employed. Whether rLH supplementation may have a benefit in some young, normo-gonadotropic women, who may develop LH deficiency following GnRH analogues, is still to be shown. The main task remains how to identify subgroups of women that may benefit from rLH supplementation. CONCLUSION:An accurate definition of the LH threshold in GnRH analogue treated cycles may contribute to the discussion of which subgroups of women may benefit from adjuvant rLH therapy.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Younis JS,Laufer Ndoi
10.1080/03007995.2017.1417827subject
Has Abstractpub_date
2018-05-01 00:00:00pages
881-886issue
5eissn
0300-7995issn
1473-4877journal_volume
34pub_type
杂志文章abstract::The manifestation of pain in any individual patient may result from a variety of underlying mechanisms that also may vary from one disease state to another. Global measures of pain intensity and relief are inadequate for characterizing specific pain qualities or identifying the unique effects of pain treatments on dif...
journal_title:Current medical research and opinion
pub_type: 社论
doi:10.1185/030079904X12924
更新日期:2004-01-01 00:00:00
abstract::Objective: A prior study found that hyaluronic acid (HA) treatment may help reduce pain medication use (such as steroids, non-steroidal anti-inflammatory drugs [NSAIDs] and opioids) among knee osteoarthritis (OA) patients in the real-world setting. This study aims to update the prior study results to include only the ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2019.1596670
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:Early involvement of specialists is associated with improved survival in ovarian cancer patients. However, only 33-60% of patients are currently being referred. A more effective strategy to get patients with an elevated risk of ovarian cancer to gynecologic oncologists is needed. The objective of this study w...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2016.1176014
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:To compare compliance/persistence, health care resource utilization, and costs associated with single-pill combination (SPC) vs. free-combination (FC) therapies among adult hypertension patients at the national and state level. Combination therapies with angiotensin receptor blocker (ARB) + calcium channel b...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2010.494462
更新日期:2010-09-01 00:00:00
abstract::The therapeutic efficacy of 100 mg spironolactone once daily in patients with congestive heart failure was evaluated in a multi-centre study in general practice. One hundred and fifteen patients were admitted to the study. Clinical and haemotological assessments were made at entry and at regular intervals throughout t...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007998009112040
更新日期:1980-01-01 00:00:00
abstract::The results of a series of studies on body fluid, electrolytes and diuretics are discussed. The findings to date indicate that the sex difference between mean potassium plasma levels in men and women is preserved into old age. Contrary to previous suggestions, there would appear to be no transient self-correcting hypo...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVES:The objective of this project was to determine pharmacy cost savings and improvement in adherence based on a combinatorial pharmacogenomic test (CPGx ) in patients who had switched or added a new psychiatric medication after having failed monotherapy for their psychiatric disorder. RESEARCH DESIGN AND METHO...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2015.1063483
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:The systematic use of 2-octyl cyanoacrylate (2-OCA) became routine in our cardiac unit in 2000. This topical skin adhesive has been used in conjunction with conventional suturing for skin closure and prevention of postoperative wound infections by means of its performance as a microbial barrier to exogenou...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079908x253807
更新日期:2008-01-01 00:00:00
abstract::Objective: To evaluate the risk of chronic kidney disease (CKD), cardiovascular disease (CVD), and osteoporotic fractures in human immunodeficiency virus (HIV) patients utilizing data within the Veteran's Affairs (VA) Administration system.Methods: A retrospective cohort study utilizing VA system claims (January 2000-...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2018.1543183
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Using a Delphi Consultation process, a group of medical writers established by the European Medical Writers Association (EMWA) set out to determine the current thinking on the problems of ghostwriting in medical publications and what should be done about them. In this context, ghostwriting is where a professi...
journal_title:Current medical research and opinion
pub_type: 指南,杂志文章
doi:10.1185/030079905x25569
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:Pseudomonas aeruginosa is a difficult-to-treat bacterial pathogen often isolated from patients with serious nosocomial infections. The goal of this analysis is to present the clinical and microbiologic effectiveness of doripenem in the treatment of infections due to P. aeruginosa. RESEARCH DESIGN AND METHODS...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1185/03007990903396790
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Adequate bowel preparation prior to colonic diagnostic procedures is essential to ensure adequate visualisation. SCOPE:This consensus aims to provide guidance as to the appropriate use of bowel preparation for a range of defined clinical circumstances. A consensus group from across Europe was convened and m...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2013.803055
更新日期:2013-08-01 00:00:00
abstract::Evidence is needed to guide therapeutic decisions on patients who had ischaemic cerebral events. The recently published European/Australasian Stroke Prevention in Reversible Ischaemia Trial (ESPRIT), an open-label randomised controlled study, compared long-term treatment of patients randomised to aspirin 30-325 mg dai...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1185/030079906X167291
更新日期:2007-02-01 00:00:00
abstract::Evidence from randomized, placebo-controlled, double-masked studies has demonstrated that verteporfin (Visudyne) therapy is effective in reducing the risk of visual acuity loss in selected groups of patients with choroidal neovascularization (CNV) due to age-related macular degeneration (AMD). Pilot studies of intravi...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079905X43659
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:Most registration studies for new osteoporosis drugs have used a combination of quantitative morphometry (QM) and visual semiquantitative reading (SQ) to define vertebral fractures. However, in the pivotal teriparatide Fracture Prevention Trial (ClinicalTrials.gov Identifier: NCT00670501), vertebral fractures...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007990902790993
更新日期:2009-04-01 00:00:00
abstract::Objectives: The purpose of this study was to assess (1) the trends of and (2) the factors associated with health information technology (HIT) use among older adults in the U.S.Methods: A decade (2009-2018) of data from the U.S. National Health Interview Survey (NHIS) was used. The trends of HIT use among older adults ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1734782
更新日期:2020-05-01 00:00:00
abstract::Objective: Type 2 diabetes (T2D) is a prevalent health problem. Oral agents, with the exception of metformin, are often discontinued with the initiation of insulin. The objective was to understand the proportion of patients discontinuing dipeptidyl peptidase-4 inhibitors (DPP-4is) and the reasons for the decision to d...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2019.1698416
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:Aliskiren is the first in a new class of orally effective direct renin inhibitors approved for the treatment of hypertension. This multiple-dose study investigated the potential for pharmacokinetic interactions between aliskiren and three drugs, each predominantly eliminated by a different clearance/metabolic...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/030079908X260934
更新日期:2008-03-01 00:00:00
abstract::The effects of xipamid and frusemide were comapred in 9 oedematous patients. Xipamid was found to be equipotent with frusemide in doses of 40 mg. and 80 mg., with respect to its effect on sodium and water excretion. The time course of action of xipamid was observed to be more prolonged than that of frusemide. It is co...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007997509113658
更新日期:1975-01-01 00:00:00
abstract::Zolmitriptan has been developed in an orally disintegrating tablet (ODT) formulation that rapidly dissolves on the tongue and can be taken quickly, conveniently and discreetly without fluid intake. In this 3-month, non-comparative, observational, post-marketing surveillance (PMS) study, 5,570 physicians prescribed the...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/030079905X46296
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:Osteoarthritis is one of the most common forms of arthritis seen in primary care. Non-steroidal anti-inflammatory drugs (NSAIDs) play an important role in the management of osteoarthritis. However, gastrointestinal (GI) side effects limit their use. Cyclooxygenase-2 (COX-2) selective inhibitors exhibit better...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1185/030079906X104722
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy and safety of epoetin theta and epoetin beta in anaemic patients with chronic kidney disease, undergoing haemodialysis and previously on stable maintenance therapy with epoetin beta. METHODS:In this multicentre, randomised, controlled, double-blind study 270 haemodialysis patients wer...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007995.2010.511084
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Improving health-related quality of life (HRQoL) should be a treatment goal for patients with Generalised Anxiety Disorder (GAD). OBJECTIVES:To assess the impact of treatment with escitalopram on HRQoL as well as the effect of relapse on HRQoL and work productivity. METHODS:This study was conducted alongsi...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/030079907X226087
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Obstructive sleep apnea syndrome (OSAS) is mostly seen in adult populations. It is known that increased levels of several inflammatory mediators play roles in OSAS and related comorbidities. Calprotectin is an inflammatory mediator that increases in some diseases such as Behçet's syndrome, bowel diseases and...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2017.1383890
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:Corticotropin-releasing hormone (CRH) is one of the most potent vasodilatory factors in the human feto-placental circulation. The expression of CRH was significantly down-regulated in patients with intrahepatic cholestasis of pregnancy (ICP). METHODS:One hundred pregnant women diagnosed with ICP at 34-34(+6)...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2014.907560
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Natalizumab is a highly effective treatment for patients with relapsing-remitting multiple sclerosis (RRMS). Treatment with natalizumab has been associated with progressive multifocal leukoencephalopathy (PML), a rare yet serious disease of the brain. Published studies have quantified the PML risk by the pre...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2013.869492
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVES:To report on the results of a recent large-scale, internet-based survey of the population, prevalence and attributes of pain experience in the United Kingdom (UK), France, Spain, Germany and Italy. METHODS:The results reported here are taken from the internet-based, 2008 National Health and Wellness Survey ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2010.542136
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:The stratum corneum (SC) pharmacokinetics of terbinafine following single-dose administration of a novel cutaneous solution (film-forming solution, FFS) containing terbinafine hydrochloride and a film-forming agent, was investigated in three studies. Terbinafine 1% cream (Lamisil) was included as a benchmark ...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1185/030079907X199664
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Long-term oral corticosteroid (OCS) therapy and related adverse events are associated with a significant burden on patients and healthcare resources. METHODS:This subgroup analysis of a randomized, open-label, parallel-group study evaluated the OCS-sparing effect of omalizumab (OMA) added to optimized asthm...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1185/03007995.2011.620950
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:It has been acknowledged that patients who receive a beta-blocker or diuretic based regimen are at increased risk of developing new-onset diabetes. Recently, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have been shown to decrease patients' odds of developing new-o...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1185/030079907X188044
更新日期:2007-06-01 00:00:00