Abstract:
:A group of nitro and amino derivatives of lucanthone was prepared and tested for antitumor activity. Reaction of 1-chloro-4-methyl-7-nitrothioxanthenone and N,N-diethylethylenediamine gave the 7-amino analogue (11) directly, accompanied by 7-amino-1-chloro-4-methylthioxanthenone. The antitumor activity of 11 was inferior to that of lucanthone and 7-hydroxylucanthone. The most active compound in the series was the nitro compound 1. In the P-388 lymphocytic leukemia screen it showed a T/C = 178 at 200 mg/kg.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Archer S,Rej Rdoi
10.1021/jm00345a020subject
Has Abstractpub_date
1982-03-01 00:00:00pages
328-31issue
3eissn
0022-2623issn
1520-4804journal_volume
25pub_type
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