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Chemical Protein Synthesis in Medicinal Chemistry.

Abstract：

:Although the majority of proteins used for biomedical research are produced using living systems such as bacteria, biological means for producing proteins can be advantageously complemented by protein semisynthesis or total chemical synthesis. The latter approach is particularly useful when the proteins to be produced are toxic for the expression system or show unusual features that cannot be easily programmed in living organisms. The aim of this review is to provide a wide overview of the use of chemical protein synthesis in medicinal chemistry with a special focus on the production of post-translationally modified proteins and backbone cyclized proteins.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Agouridas V,El Mahdi O,Melnyk O

doi

10.1021/acs.jmedchem.0c01082

subject

Has Abstract

pub_date

2020-12-24 00:00:00

pages

15140-15152

issue

24

eissn

0022-2623

issn

1520-4804

journal_volume

63

pub_type

杂志文章

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