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Studies on 1,2,3-triazoles. 10. Synthesis and antiallergic properties of 9-oxo-1H,9H-benzothiopyrano[2,3-d]-1,2,3-triazoles and their S-oxides.

Abstract：

:Selected derivatives of 9-oxo-1H,9H-benzothiopyrano[2,3-d]-1,2,3-triazole, a new heterocyclic ring system, and their S-oxides have been prepared and evaluated for antiallergic activity in the rat passive cutaneous anaphylaxis screen. Several of the compounds show intravenous potencies similar to or greater than that of disodium cromoglycate, the most potent being 6,7-dimethyl-9-oxo-1H,9H-benzothiopyrano[2,3-d]-1,2,3-triazole and its 4,4-dioxide.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Buckle DR,Rockell CJ,Smith H,Spicer BA

doi

10.1021/jm00368a021

subject

Has Abstract

pub_date

1984-02-01 00:00:00

pages

223-7

issue

2

eissn

0022-2623

issn

1520-4804

journal_volume

27

pub_type

杂志文章

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