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Thiocamptothecin.

Abstract：

:The synthesis and the X-ray structure of 16a-thiocamptothecin (TCPT), the thiopyridone analog of camptothecin (CPT), are accomplished. The crystal contains two structurally identical, yet independent molecules. Both of them are connected to other molecules via two intermolecular hydrogen bonds. S-methylation of TCPT leads to the cleavage of the C-ring. The cytotoxic activity of TCPT was evaluated against different human tumor cell lines using CPT as reference compound.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Samorì C,Guerrini A,Varchi G,Zunino F,Beretta GL,Femoni C,Bombardelli E,Fontana G,Battaglia A

doi

10.1021/jm8001982

subject

Has Abstract

pub_date

2008-05-22 00:00:00

pages

3040-4

issue

10

eissn

0022-2623

issn

1520-4804

journal_volume

51

pub_type

杂志文章

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