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MutT Homolog 1 (MTH1): The Silencing of a Target.

Abstract：

:MTH1 is a member of the nudix phosphohydrolase superfamily of enzymes, and it is involved in nucleotide pool homeostasis. The protein exerts its scavenging action by hydrolyzing oxidized nucleotides, thus avoiding their misincorporation into replicating DNA. Recent reports have validated its inhibition as a potential broad-spectrum target in oncology and have described small molecules able to engage this target with antiproliferative effect. In the accompanying paper (DOI: 10.1021/acs.jmedchem.5b01760 ), a team at AstraZeneca led by Jason G. Kettle elegantly demonstrated the complete lack of antiproliferative activity of cancer cells to highly potent MTH1 inhibitors.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Papeo G

doi

10.1021/acs.jmedchem.6b00283

subject

Has Abstract

pub_date

2016-03-24 00:00:00

pages

2343-5

issue

6

eissn

0022-2623

issn

1520-4804

journal_volume

59

pub_type

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