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Ergot alkaloids. Synthesis of nitrosourea derivatives of ergolines as potential anticancer agents.

Abstract：

:Nitrosourea derivatives of ergolines have been synthesized for the purpose of obtaining agents with both prolactin-and tumor-inhibitory activity. Two derivatives of 8-amino-6-methylergoline (3), 8-[3-(2-chloroethyl)-3-nitrosoureido]-1-nitroso-6-methylergoline (5c) and 8-[3-2-chloroethyl)-3-nitrosoureido]-6-methylergoline (5a), have been prepared. In addition, nitroso (7) and chloroethylcarbamyl (8) derivatives of elymoclavine (6) are reported. Compounds 5a and 5c have activity against L1210 leukemia in mice but only moderate prolactin-inhibiting activity. The chloroethylcarbamyl derivative 8 of elymoclavine is a potent prolacting inhibitor.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Crider AM,Lu CK,Floss HG,Cassady JM,Clemens JA

doi

10.1021/jm00187a008

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

32-5

issue

1

eissn

0022-2623

issn

1520-4804

journal_volume

22

pub_type

杂志文章

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