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Synthesis and in vitro multidrug resistance modulating activity of a series of dihydrobenzopyrans and tetrahydroquinolines.

Abstract：

:A series of dihydrobenzopyrans and tetrahydroquinolines was synthesized and pharmacologically tested for their ability to inhibit P-glycoprotein mediated daunomycin efflux in multidrug resistant CCRF-CEM vcr1000 cells. Several compounds exhibit activities in the range of the reference compounds verapamil and propafenone. Preliminary structure-activity relationship studies propose the importance of high molar refractivity values of the compounds and the presence of an additional basic nitrogen atom.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Hiessböck R,Wolf C,Richter E,Hitzler M,Chiba P,Kratzel M,Ecker G

doi

10.1021/jm980517+

keywords:

subject

Has Abstract

pub_date

1999-06-03 00:00:00

pages

1921-6

issue

11

eissn

0022-2623

issn

1520-4804

pii

jm980517+

journal_volume

42

pub_type

杂志文章

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