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A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization.

Abstract：

:The prevalence of multidrug resistance among clinically significant bacterial pathogens underscores a critical need for the development of new classes of antibiotics with novel mechanisms of action. Here we describe the synthesis and evaluation of a guanidinomethyl biaryl compound {1-((4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)methyl)guanidine} that targets the bacterial cell division protein FtsZ. In vitro studies with various bacterial FtsZ proteins reveal that the compound alters the dynamics of FtsZ self-polymerization via a stimulatory mechanism, while minimally impacting the polymerization of tubulin, the closest mammalian homologue of FtsZ. The FtsZ binding site of the compound is identified through a combination of computational and mutational approaches. The compound exhibits a broad spectrum of bactericidal activity, including activity against the multidrug-resistant pathogens methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE), while also exhibiting a minimal potential to induce resistance. Taken together, our results highlight the compound as a promising new FtsZ-targeting bactericidal agent.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Kaul M,Parhi AK,Zhang Y,LaVoie EJ,Tuske S,Arnold E,Kerrigan JE,Pilch DS

doi

10.1021/jm3012728

subject

Has Abstract

pub_date

2012-11-26 00:00:00

pages

10160-76

issue

22

eissn

0022-2623

issn

1520-4804

journal_volume

55

pub_type

杂志文章

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