Synthesis and biologic distribution of mercapto derivatives of palmitic acid.

Abstract:

:Mercapto derivatives of palmitic acid are capable of binding 99mTc. Based on the hypothesis that 99mTc-labeled palmitic acid derivatives would behave biologically like palmitic acid and thus could be used as myocardial imaging agents, three mercaptopalmitic acid derivatives have been prepared. The synthesis of 2-mercaptopalmitic acid, 2-mercapto-1,16-hexadecanedioic acid, and 16-mercaptopalmitic acid was accomplished by reaction of the corresponding bromo compound with thiourea. The 35S-labeled compounds and [16-14C]palmitic acid were evaluated in rats with a heat-inflicted myocardial infarction to study the effect of the introduction of the mercapto group. The organ distribution of 2-[35S]mercaptopalmitic acid was most similar to that of [16-14C]palmitic acid.

journal_name

J Med Chem

authors

Livni E,Davis MA,Warner VD

doi

10.1021/jm00191a024

subject

Has Abstract

pub_date

1979-05-01 00:00:00

pages

580-3

issue

5

eissn

0022-2623

issn

1520-4804

journal_volume

22

pub_type

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