Abstract:
:The synthesis and CNS activity of a noval class of annelated 1,4-benzodiazepines, the aminomethylene-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepines, are described. An investigation of the structure--activity relationships in the series derived from 8-chloro-2,4-dihydro-2-dimethylaminomethylene-6-phenyl-1H-imidazo[1,2-a][1,4]-benzodiazepin-1-one (10) led to the synthesis of a group of compounds with potent minor tranquillizer activity.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Ager IR,Danswan GW,Harrison DR,Kay DP,Kennewell PD,Taylor JBdoi
10.1021/jm00218a009subject
Has Abstractpub_date
1977-08-01 00:00:00pages
1035-41issue
8eissn
0022-2623issn
1520-4804journal_volume
20pub_type
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